Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro. [PDF]
Journal of Clinical Investigation, 1995 Plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of tissue-type plasminogen activator (t-PA) and urokinase plasminogen activator, is an important regulator of the blood fibrinolytic system. Elevated plasma levels of PAI-1 are associated with thrombosis, and high levels of PAI-1 within platelet-rich clots contribute to their resistance ...
D T, Eitzman +6 more
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Thrombolysis and interventional cardiology; experiences from the 80's [PDF]
, 1992 In October 1978 I assumed the position of cardiologist at the Catharina Hospital in Eindhoven at the time when the cardiothoracic surgery programm began in this hospital.
Bonnier, J.J.R.M. (Hans)
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Plasminogen binding and activation at the surface of Helicobacter pylori CCUG 17874 [PDF]
, 1998 The binding of iodine-labelled plasminogen to Helicobacter pylori CCUG 17874 was characterized. Inhibition of the binding was observed after preincubation of H.
Pantzar, Martina +2 more
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International Journal of Molecular Medicine, 2010 Proteolysis in general and particularly the serine proteases are causally involved in many physiological processes and different diseases. Recently it was reported that plasminogen activator inhibitor type one (PAI-1) inactivation can alleviate the symptoms of Alzheimer's disease and reduce the body weight of obese individuals.
Ewa, Skrzypczak-Jankun, Jerzy, Jankun
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Washington University Record, October 8, 1992 [PDF]
, 1992 https://digitalcommons.wustl.edu/record/1596/thumbnail ...
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Effects of Brassicaceae Isothiocyanates on Prostate Cancer [PDF]
, 2016 Despite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men.
CARTEA, ELENA +4 more
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An investigation of the nature of plasminogen activator inhibitor type-I (PAI-I) to improve upon known small molecule inhibitors [PDF]
, 2019 Plasminogen activator inhibitor type-I (PAI-I ) is a serpin superfamily member protein that acts as the major inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA).
Powers, Justin A.
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Chemistry & Biology, 2013 Plasminogen activator inhibitor-1 (PAI-1), a serpin, is the physiological inhibitor of tissue-type and urokinase-type plasminogen activators and thus also an inhibitor of fibrinolysis and tissue remodeling. It is a potential therapeutic target in many pathological conditions, including thrombosis and cancer.
Lin, Zhonghui +6 more
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Acceleration of the thrombin inactivation of single chain urokinase-type plasminogen activator (pro-urokinase) by thrombomodulin. [PDF]
Journal of Clinical Investigation, 1991 The in vitro effects of thrombomodulin on the inactivation of single chain urokinase-type plasminogen activator (scu-PA) by thrombin were investigated by incubating scu-PA with varying concentrations of human thrombin, in both the absence and presence of soluble rabbit thrombomodulin.
Munk, G.A.W. de +2 more
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The urokinase-type plasminogen activator, its inhibitors and its receptor - the new prognostic factors in solid cancers [PDF]
, 1997 The urokinase-type plasminogen activator (uPA), its inhibitors (PAI-1 and PAI-2) and its receptor (uPAR) play nan important role in the degradation of the intercellular tissue, the process which affects the ability of cancer cells to invade to ...
Borštnar, Simona +2 more
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