International Journal of Molecular Medicine, 2011 Obesity and diabetes once considered 'rich man's diseases' are one of the biggest public health challenges of the 21st century. Obesity being a gateway to diabetes is a global problem. The supporting statistics are alarming since diabetes is reaching pandemic proportion all over the world. Eighty percent of all patients with diabetes live in developing
Jankun, Jerzy +2 more
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Dietary fiber linked to decreased inflammation in overweight minority youth [PDF]
, 2015 textObjective: To examine the relationship between diet and inflammation, and adiposity in minority youth. Design and Methods: A cross-sectional analysis of 142 overweight (≥85th BMI percentile) Hispanic and African American adolescents (14-18 y) with ...
Miller, Samantha Jean
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Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities [PDF]
, 2015 Dobesilate (2,5-dihydroxyphenyl sulfonate, DHPS) was recently identified as the most potent member of a family of fibroblast growth factor (FGF) inhibitors headed by gentisic acid, one of the main catabolites of aspirin.
Javier Angulo +7 more
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Structural and functional analysis of the interaction between vitronectin and the thrombin-antithrombin pair [PDF]
, 2001 Vitronectin is a multifunctional glycoprotein found both in the circulation and in the extracellular matrix. Circulating vitronectin is in monomeric form while matrix and tissue associated vitronectin tend to form multimers. Interacts with a wide variety
Oguz-Ozen, Secil
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Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling [PDF]
, 2019 Lifestyle factors are important drivers of chronic diseases, including cardiovascular syndromes, with low grade inflammation as a central player. Attenuating myeloperoxidase (MPO) activity, an inflammatory enzyme associated with obesity, hypertension and
de Boer, Rudolf A +6 more
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Investigations into the fibrinolytic system and haptoglobin types in certain hereditary and acquired haemostatic disorders and the presence of circulating anticoagulants in such states [PDF]
, 1963 I THE FIBRINOLYTIC SYSTEM: A review of the literature is presented together with an evaluation of the present methods for the measurement of its parameters.The methods adopted in the course of this study include (l) the heated fibrin plate for the ...
Kamel, Karim
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European Journal of Biochemistry, 2003 Plasminogen activator inhibitor‐1 (PAI‐1) belongs to the serpin family of serine proteinase inhibitors. Serpins inhibit their target proteinases by an ester bond being formed between the active site serine of the proteinase and the P1 residue of the reactive centre loop (RCL) of the serpin, followed by insertion of the RCL into β‐sheet A of the serpin.
Bødker, Julie S. +5 more
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Design, synthesis, and biological evaluation of non-symmetric smal [PDF]
, 2014 Plasminogen activator inhibitor-1 (PAI-1) is a member of the serpin family of proteins, a primary inhibitor of both tissue-type and urokinase-type plasminogen activators in plasma, and is a well-established risk factor in various disease conditions ...
Anumala, Himabindu
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Optimization of Clustering and Database Screening Procedures for Cavbase and Virtual Screening for Novel Antimalarial and Antibacterial Molecules [PDF]
, 2012 Im Zyklus der rationellen Arzneimittelentwicklung werden Affinität und Selektivität von potentiellen Wirkstoffen intensiv erforscht. Da diese beiden Eigenschaften keine lineare Abhängigkeit zueinander aufweisen, führt höhere Affinität nicht ...
Glinca, Serghei
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An antibody that targets cell-surface glucose-regulated protein-78 inhibits expression of inflammatory cytokines and plasminogen activator inhibitors by macrophages. [PDF]
J Cell Biochem, 2023 Gunner CB +6 more
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