Hemostazni sistem i ishemijska bolest mozga (specifičnosti vezane za moždanu cirkulaciju I kliničke implikacije) [PDF]
Vojnosanitetski Pregled, 2002 Raičević Ranko +3 more
doaj +3 more sources
Cathepsin L in metastatic bone disease: therapeutic implications [PDF]
, 2010 Cathepsin L is a lysosomal cysteine proteinase primarily devoted to the metabolic turnover of intracellular proteins. However, accumulating evidence suggests this endopeptidase may be also implicated in the regulation of other important biological ...
CRESCIMANNO, Marilena +4 more
core +1 more source
Targeting kallikrein-related peptidases in prostate cancer [PDF]
, 2014 Introduction: Novel therapeutic compounds are needed for prostate cancer (CaP), given the limitations of already used drugs and the disease’s mortality, often attributed to castrate resistance.
Avgeris, Margaritis +2 more
core +1 more source
Integrins as biomechanical sensors of the microenvironment [PDF]
, 2021 Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional hubs transmitting signals between cells and their environment. Recent
Ivaska, Johanna +2 more
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Minactivin: A human monocyte product which specifically inactivates urokinase‐type plasminogen activators [PDF]
European Journal of Biochemistry, 1983 Culture supernatants from monolayers of human peripheral monocytes strongly inhibited colorimetric assays of urokinase in which plasmin was measured by esterolysis. This inhibitory activity of monocyte culture supernatant was enhanced after culture with muramyl dipeptide.
J P, Golder, R W, Stephens
openaire +2 more sources
Yersinia pestis targets neutrophils via complement receptor 3 [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111208/1/cmi12391 ...
Bohman, Lesley +5 more
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Le Lait, 2001 Étude approfondie de la dénaturation thermique de la plasmine, du plasminogène et des activateurs du plasminogène natifs du lait bovin. La dénaturation thermique entre 60 °C et 140 °C de la plasmine, du plasminogène et des activateurs du plasminogène natifs du lait bovin a été étudiée à l'aide de méthodes enzymatiques optimisées.
Denis, Thierry +2 more
openaire +1 more source
Molecular response to aromatase inhibitor treatment in primary breast cancer [PDF]
, 2007 BackgroundAromatase inhibitors such as anastrozole and letrozole are highly effective suppressants of estrogen synthesis in postmenopausal women and are the most effective endocrine treatments for hormone receptor positive breast cancer in such women ...
Alan Mackay +58 more
core +2 more sources
Mechanism of Inactivation of Plasminogen Activator Inhibitor-1 by a Small Molecule Inhibitor [PDF]
Journal of Biological Chemistry, 2007 The inactivation of plasminogen activator inhibitor-1 (PAI-1) by the small molecule PAI-1 inhibitor PAI-039 (tiplaxtinin) has been investigated using enzymatic analysis, direct binding studies, site-directed mutagenesis, and molecular modeling studies.
Natalia V, Gorlatova +7 more
openaire +2 more sources
The X-ray structure of carboxypeptidase a inhibited by a thiirane mechanism-based ihibitor [PDF]
, 2010 The three-dimensional X-ray crystal structure of carboxypeptidase A, a zinc-dependent hydrolase, covalently modified by a mechanism-based thiirane inactivator, 2-benzyl-3,4-epithiobutanoic acid, has been solved to 1.38 Å resolution.
Avilés, Francesc X. +4 more
core +1 more source