Results 11 to 20 of about 648 (173)
Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1 [PDF]
Biochemical Journal, 2003 XR5118 [(3Z,6Z)-6-benzylidine-3-(5-(2-dimethylaminoethyl-thio-))-2-(thienyl)methylene-2,5-dipiperazinedione hydrochloride] can inactivate the anti-proteolytic activity of the serpin plasminogen activator inhibitor-1 (PAI-1), a potential therapeutic target in cancer and cardiovascular diseases. Serpins inhibit their target proteases by the P1 residue of
Anja P. Einholm +9 more
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International Journal of Molecular Medicine, 2011 Obesity and diabetes once considered 'rich man's diseases' are one of the biggest public health challenges of the 21st century. Obesity being a gateway to diabetes is a global problem. The supporting statistics are alarming since diabetes is reaching pandemic proportion all over the world. Eighty percent of all patients with diabetes live in developing
Jerzy Jankun
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Journal of Clinical Laboratory Analysis, Volume 36, Issue 6, June 2022., 2022 We performed thromboelastography on the whole blood of pregnant women, and then analyzed the data. We found that thromboelastography has a good application prospect in the differential diagnosis of normal pregnancy and pregnancy complications. Abstract Background This observational study aimed to compare the potential application of thromboelastography
Hongyan Zhao +3 more
wiley +1 more source
Molecular analysis of vascular gene expression
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 4, May 2022., 2022 Abstract A State of the Art lecture entitled “Molecular Analysis of Vascular Gene Expression” was presented at the ISTH Congress in 2021. Endothelial cells (ECs) form a critical interface between the blood and underlying tissue environment, serving as a reactive barrier to maintain tissue homeostasis. ECs play an important role in not only coagulation,
Martijn A. Van der Ent +2 more
wiley +1 more source
Plasminogen activator inhibitor-1 polymers, induced by inactivating amphipathic organochemical ligands [PDF]
Biochemical Journal, 2003 Negatively charged organochemical inactivators of the anti-proteolytic activity of plasminogen activator inhibitor-1 (PAI-1) convert it to inactive polymers. As investigated by native gel electrophoresis, the size of the PAI-1 polymers ranged from dimers to multimers of more than 20 units.
Pedersen, K.E. +6 more
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Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1 [PDF]
International Journal of Cancer, 1999 Human kallikrein 2 (hK2) is a serine protease expressed predominantly in the prostate which has 80% homology to prostate-specific antigen (PSA). hK2 is an active trypsin-like protease which has been shown by immuno-histochemical staining to be more highly expressed in prostate carcinoma than in benign prostate tissue. Unlike PSA, hK2 activates pro-PSA ,
S D, Mikolajczyk +3 more
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Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins [PDF]
The Journal of Cell Biology, 2003 The binding of urokinase plaminogen activator (uPA) to its cell surface receptor (uPAR; CD87) promotes cell adhesion by increasing the affinity of the receptor for both vitronectin (VN) and integrins. We provide evidence that plasminogen activator inhibitor (PAI)-1 can detach cells by disrupting uPAR–VN and integrin–VN interactions and that it does so ...
Czekay, Ralf-Peter +3 more
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Minactivin: A human monocyte product which specifically inactivates urokinase‐type plasminogen activators [PDF]
European Journal of Biochemistry, 1983 Culture supernatants from monolayers of human peripheral monocytes strongly inhibited colorimetric assays of urokinase in which plasmin was measured by esterolysis. This inhibitory activity of monocyte culture supernatant was enhanced after culture with muramyl dipeptide.
J P, Golder, R W, Stephens
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Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator [PDF]
, 2006 BACKGROUND: Urokinase-type plasminogen activator (uPA) plays a major role in extracellular proteolytic events associated with tumor cell growth, migration and angiogenesis.
Deck, Lorraine M +4 more
core +3 more sources
Le Lait, 2001 Étude approfondie de la dénaturation thermique de la plasmine, du plasminogène et des activateurs du plasminogène natifs du lait bovin. La dénaturation thermique entre 60 °C et 140 °C de la plasmine, du plasminogène et des activateurs du plasminogène natifs du lait bovin a été étudiée à l'aide de méthodes enzymatiques optimisées.
Denis, Thierry +2 more
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