Results 21 to 30 of about 627 (174)
Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1 [PDF]
Biochemical Journal, 2003 XR5118 [(3Z,6Z)-6-benzylidine-3-(5-(2-dimethylaminoethyl-thio-))-2-(thienyl)methylene-2,5-dipiperazinedione hydrochloride] can inactivate the anti-proteolytic activity of the serpin plasminogen activator inhibitor-1 (PAI-1), a potential therapeutic target in cancer and cardiovascular diseases. Serpins inhibit their target proteases by the P1 residue of
Einholm, Anja P +9 more
openaire +2 more sources
Modes of invasion during tumour dissemination
Molecular Oncology, Volume 11, Issue 1, Page 5-27, January 2017., 2017 This Review gives an overview of cell migration mechanisms and describes the different individual and collective modes of invasion, the plasticity that enables cancer cells to switch between modes, and the determinants of this plasticity. Therapeutic challenges arising from migratory plasticity and the potential targets that could block completely ...
Pahini Pandya +2 more
wiley +1 more source
A specific plasminogen activator inhibitor‐1 antagonist derived from inactivated urokinase
Journal of Cellular and Molecular Medicine, 2016 AbstractFibrinolysis is a process responsible for the dissolution of formed thrombi to re‐establish blood flow after thrombus formation. Plasminogen activator inhibitor‐1 (PAI‐1) inhibits urokinase‐type and tissue‐type plasminogen activator (uPA and tPA) and is the major negative regulator of fibrinolysis.
Gong, Lihu +13 more
openaire +3 more sources
Low-affinity heparin stimulates the inactivation of plasminogen activator inhibitor-1 by thrombin [PDF]
Blood, 1994 The influence of heparin on the reaction between thrombin and plasminogen activator inhibitor-1 (PAI-1) has been examined. With a 50- fold excess of PAI-1, the rate constant for the inhibition of thrombin was 458 mol/L-1s-1, which increased to 5,000 mol/L-1s-1 in the presence of 25 micrograms/mL unfractionated heparin or heparin with low affinity for ...
P A, Patston, M, Schapira
openaire +3 more sources
Cholesterol, Volume 2013, Issue 1, 2013., 2013 The endothelium is the primary target for biochemical or mechanical injuries caused by the putative risk factors of atherosclerosis. Endothelial dysfunction represents the ultimate link between atherosclerotic risk factors that promote atherosclerosis.
Esin Eren +3 more
wiley +1 more source
The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease
Cardiology Research and Practice, Volume 2012, Issue 1, 2012., 2012 Cardiovascular disease is a complex disorder involving multiple pathophysiological processes, several of which involve activation of toll‐like receptors (TLRs) of the innate immune system. As sentinels of innate immunity TLRs are nonclonally germline‐encoded molecular pattern recognition receptors that recognize exogenous as well as tissue‐derived ...
Rolf Spirig +3 more
wiley +1 more source
Sambandet mellan αs1-kasein, proteolytisk aktivitet och sammansättning i mjölk från svenska getter [PDF]
, 2021 In the recent decade, locally produced food has gained in interest among Swedish consumers. Consumer values for buying local food has to do with concerns about diversity, purity and authenticity of food as well as a desire to support rural areas.
Larsson, Emma
core
Rapid inactivation of the plasminogen-activator inhibitor upon secretion from cultured human endothelial cells [PDF]
Biochemical Journal, 1986 In conditioned medium (CM) from cultured human endothelial cells, two forms of plasminogen-activator inhibitor (PA-inhibitor) can be demonstrated: a fast-acting active form and an immunologically related, inactive form. Evidence is presented that endothelial cells produce active PA-inhibitor which is rapidly inactivated upon secretion into the medium ...
Kooistra, T. +2 more
openaire +3 more sources
Hypoxia‐Inducible Factor in Thyroid Carcinoma
Journal of Thyroid Research, Volume 2011, Issue 1, 2011., 2011 Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia‐inducible factor‐1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
Natalie Burrows +5 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 5, Issue 1, Page 3-15, 2008., 2008 Agaricus blazei Murrill (ABM) popularly known as ‘Cogumelo do Sol’ in Brazil, or ‘Himematsutake’ in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary‐medicinal biotechnological species.
F. Firenzuoli, L. Gori, G. Lombardo
wiley +1 more source