Results 21 to 30 of about 648 (173)
The X-ray structure of carboxypeptidase a inhibited by a thiirane mechanism-based ihibitor [PDF]
, 2010 The three-dimensional X-ray crystal structure of carboxypeptidase A, a zinc-dependent hydrolase, covalently modified by a mechanism-based thiirane inactivator, 2-benzyl-3,4-epithiobutanoic acid, has been solved to 1.38 Å resolution.
Avilés, Francesc X. +4 more
core +1 more source
Sambandet mellan αs1-kasein, proteolytisk aktivitet och sammansättning i mjölk från svenska getter [PDF]
, 2021 In the recent decade, locally produced food has gained in interest among Swedish consumers. Consumer values for buying local food has to do with concerns about diversity, purity and authenticity of food as well as a desire to support rural areas.
Larsson, Emma
core
Mechanism of Inactivation of Plasminogen Activator Inhibitor-1 by a Small Molecule Inhibitor [PDF]
Journal of Biological Chemistry, 2007 The inactivation of plasminogen activator inhibitor-1 (PAI-1) by the small molecule PAI-1 inhibitor PAI-039 (tiplaxtinin) has been investigated using enzymatic analysis, direct binding studies, site-directed mutagenesis, and molecular modeling studies.
Natalia V, Gorlatova +7 more
openaire +2 more sources
Modes of invasion during tumour dissemination
Molecular Oncology, Volume 11, Issue 1, Page 5-27, January 2017., 2017 This Review gives an overview of cell migration mechanisms and describes the different individual and collective modes of invasion, the plasticity that enables cancer cells to switch between modes, and the determinants of this plasticity. Therapeutic challenges arising from migratory plasticity and the potential targets that could block completely ...
Pahini Pandya +2 more
wiley +1 more source
A specific plasminogen activator inhibitor‐1 antagonist derived from inactivated urokinase
Journal of Cellular and Molecular Medicine, 2016 AbstractFibrinolysis is a process responsible for the dissolution of formed thrombi to re‐establish blood flow after thrombus formation. Plasminogen activator inhibitor‐1 (PAI‐1) inhibits urokinase‐type and tissue‐type plasminogen activator (uPA and tPA) and is the major negative regulator of fibrinolysis.
Gong, Lihu +13 more
openaire +3 more sources
Low-affinity heparin stimulates the inactivation of plasminogen activator inhibitor-1 by thrombin [PDF]
Blood, 1994 The influence of heparin on the reaction between thrombin and plasminogen activator inhibitor-1 (PAI-1) has been examined. With a 50- fold excess of PAI-1, the rate constant for the inhibition of thrombin was 458 mol/L-1s-1, which increased to 5,000 mol/L-1s-1 in the presence of 25 micrograms/mL unfractionated heparin or heparin with low affinity for ...
P A, Patston, M, Schapira
openaire +3 more sources
Cholesterol, Volume 2013, Issue 1, 2013., 2013 The endothelium is the primary target for biochemical or mechanical injuries caused by the putative risk factors of atherosclerosis. Endothelial dysfunction represents the ultimate link between atherosclerotic risk factors that promote atherosclerosis.
Esin Eren +3 more
wiley +1 more source
The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease
Cardiology Research and Practice, Volume 2012, Issue 1, 2012., 2012 Cardiovascular disease is a complex disorder involving multiple pathophysiological processes, several of which involve activation of toll‐like receptors (TLRs) of the innate immune system. As sentinels of innate immunity TLRs are nonclonally germline‐encoded molecular pattern recognition receptors that recognize exogenous as well as tissue‐derived ...
Rolf Spirig +3 more
wiley +1 more source
The Inhibitory Effect of siRNAs on The High Glucose-Induced Overexpression of TGF-β1 in Mesangial Cells [PDF]
, 2006 Diabetic nephropathy is characterized by an expansion of the glomerular mesangium, caused by mesangial cell proliferation and an excessive accumulation of extracellar matrix (ECM) proteins, which eventually leading to glomerulosclerosis. TGF-β1 was found
Baricos +33 more
core +2 more sources
Rapid inactivation of the plasminogen-activator inhibitor upon secretion from cultured human endothelial cells [PDF]
Biochemical Journal, 1986 In conditioned medium (CM) from cultured human endothelial cells, two forms of plasminogen-activator inhibitor (PA-inhibitor) can be demonstrated: a fast-acting active form and an immunologically related, inactive form. Evidence is presented that endothelial cells produce active PA-inhibitor which is rapidly inactivated upon secretion into the medium ...
Kooistra, T. +2 more
openaire +3 more sources