Results 41 to 50 of about 433,927 (377)

Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

Cell Reports, 2019
Summary: Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic cells with the fungal surrogate zymosan causes decreases of pyruvate, citrate, itaconate, and α ...
Saioa Márquez, José Javier Fernández, Cristina Mancebo, Carmen Herrero-Sánchez, Sara Alonso, Tito A. Sandoval, Macarena Rodríguez Prados, Juan R. Cubillos-Ruiz, Olimpio Montero, Nieves Fernández, Mariano Sánchez Crespo   +10 more
doaj   +1 more source

Data showing effects of a PI3K-δ inhibitor on neutrophil superoxide production during FPR2 activation and reactivation

Data in Brief, 2020
Reactive oxygen species (ROS) generated by the NADPH oxidase are crucial for antimicrobial host defense and also play a role in the regulation of inflammatory processes.
André Holdfeldt, Martina Sundqvist, Claes Dahlgren, Huamei Forsman   +3 more
doaj   +1 more source

Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]

, 2018
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella, Businaro, Rita, Capoano, Raffaele, Corsi, Mariangela, DE FALCO, Elena, Frati, Giacomo, Pagano, Francesca, Petrozza, Vincenzo, Pierangelatotta,, Procaccini, Eugenio, Salvati, Bruno, Scaccia, Eleonora, Siciliano, Camilla, Teresa Vietri, Maria   +13 more
core   +2 more sources

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]

, 2018
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast, AD Michelson, B Labarthe, B Shen, C Patrono, CT Ammollo, D Capodanno, D Gailani, DA Gorog, Diana A. Gorog, DM Coenen, E Álvarez, ER Bates, F Kabirian, F Müller, F Semeraro, G Stephens, H Brogren, HE Speich, HE Speich, HJ Weiss, HJ Weiss, HR Baumgartner, J Zilberman-Rudenko, JD McFadyen, JI Weitz, JM Cosemans, JP Collet, JP Collet, K Hosokawa, K Nagatsuka, KS Sakariassen, L Valerio, LF Brass, M Cattaneo, M Farag, M Humbert, M Larsson, M Li, M Ungerer, MA Bailey, MI Furman, MJ Price, ML Montfoort von, MS Sabatine, P Andre, P Seizer, PA Borne von dem, PP Wadowski, R Hellmuth, R Nergiz-Unal, RA Ajjan, S Goto, S Goto, SA Shaya, SB Larsen, SJ Marciniak, T Heitzer, T Renné, VT Turitto, VT Turitto, WA Schumacher, WS Nesbitt, X Wang, Y Yano, YC Lau, ZM Ruggeri   +66 more
core   +2 more sources

Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

Platelets, 2022
CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule ...
Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Marta Ayala Ávila   +3 more
doaj   +1 more source

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

The expression of platelet-activating factor receptor modulates the cisplatin sensitivity of ovarian cancer cells: a novel target for combination therapy

British Journal of Cancer, 2014
Background:Ovarian cancer has the highest mortality rate of the gynaecological cancers. Although cisplatin (CDDP) is an effective treatment for ovarian cancer, recurrence is frequent and leads to death.
Y. Yu, X. Zhang, S. Hong, M. Zhang, Q. Cai, M. Zhang, W. Jiang, C. Xu   +7 more
semanticscholar   +1 more source

Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]

, 2017
Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J., Meijer, Alexander B., Mertens, Koen, Simpson, Pelle J., van Alphen, Floris P.J., van den Biggelaar, Maartje, van den Eshof, Bart L., Zanivan, Sara   +7 more
core   +2 more sources

Synthesis and Biological Evaluation of Resveratrol Methoxy Derivatives

Molecules, 2023
Resveratrol, a naturally occurring stilbene, exhibits numerous beneficial health effects. Various studies have demonstrated its diverse biological actions, including anti-oxidant, anti-inflammatory, and anti-platelet properties, thereby supporting its ...
Elizabeth Fragopoulou, Katerina Gkotsi, Filio Petsini, Katerina Gioti, Amalia D. Kalampaliki, George Lambrinidis, Ioannis K. Kostakis, Roxane Tenta   +7 more
doaj   +1 more source

Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells

Journal of Hematology & Oncology, 2014
BackgroundGenetic alterations, including the overexpression of epidermal growth factor receptor (EGFR), play a crucial role in ovarian carcinogenesis.
Yi Yu, Ming-xing Zhang, Xiaoyan Zhang, Q. Cai, Shanshan Hong, Wei Jiang, Congjian Xu   +6 more
semanticscholar   +1 more source