Results 201 to 210 of about 74,252 (240)

Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy. [PDF]

Biomark Res
Yan M, Wang Z, Qiu Z, Cui Y, Xiang Q.
europepmc   +1 more source

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

Aggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao, Jingyi Si, Shisong Jing, Bingmei Wang, Yueshan Xu, Jiyu Guan, Quan Liu, Jianlei Shen, Min Lv, Li Wang, Changfeng Zhu   +10 more
wiley   +1 more source

Exploring the Emerging Association Between Immune Checkpoint Inhibitors and Thrombosis. [PDF]

J Clin Med
Fawaz H, Numan H, El Charif MH, Charbel N, El Khoury S, Rizkallah J, El Masri A, Tfayli A, Kreidieh F.   +8 more
europepmc   +1 more source

Highly Stable Aggregation‐Induced Emission‐Functionalized Histatin1 Coated With Platelet Vesicles for Diabetic Wound Healing

Aggregate, EarlyView.
Diabetic wound healing is blocked by persistent inflammation and oxidative stress. Bioactive substances like growth factors and Hsts promote repair but lack long‐term stability. Herein, a platelet membrane‐coated nanoparticle system (PNP) is proposed to achieve enhanced retention of aggregation‐induced emissive (AIE) molecular‐modified Hst1 (Hst1‐AIE ...
Xiaoxuan Lei, Judun Zheng, Xu Chen, Liwen Liang, Zhuohong Li, Cancan Huang, Minghai Zhao, Gang Wu, Yuhui Liao, Bin Yang   +9 more
wiley   +1 more source

Role of Dual Pathway Inhibition in Secondary Prevention of Coronary Artery Disease. [PDF]

Cureus
Ahmad F, Husnain A, Hayat MF, Ashraf MA, Arif MA, Butt MZA, Qureshi AJ, Hamza M.   +7 more
europepmc   +1 more source

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

Aggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Anna I. Sulatskaya   +3 more
wiley   +1 more source

Design and Pharmacological Characterization of a Novel Antithrombotic P2Y₁ Receptor-Based Vaccine. [PDF]

Int J Mol Sci
Al Meanazel O, Alshbool FZ, Khasawneh FT.   +2 more
europepmc   +1 more source

Understanding Drug Interactions in Antiplatelet Therapy for Atherosclerotic Vascular Disease: A Systematic Review. [PDF]

CNS Neurosci Ther
Huang X, Song J, Zhang X, Wang M, Ding Y, Ji X, Zhou D, Meng R.   +7 more
europepmc   +1 more source

Identification of bioactive compounds and molecular targets of Fuke Huahuang formulation to treat vaginitis

Animal Models and Experimental Medicine, EarlyView.
Fuke Huahuang formulation (FHF) is used to treat vaginitis, and it exerts a promising anti‐inflammatory effect in clinical use. However, the detailed components and mechanisms of FHF for treating vaginitis remain unreported, and further preclinical evaluation is required to reveal its potential pharmacological activities against vaginitis.
Huiyu Liu, Jie Mo, Cheng Liang, Qingting Chen, Bin Yang, Jiaqi Liu   +5 more
wiley   +1 more source