Results 201 to 210 of about 222,697 (389)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Purification and Characterization of BmooAi: A New Toxin fromBothrops moojeniSnake Venom That Inhibits Platelet Aggregation [PDF]

, 2014
Mayara Ribeiro de Queiroz, Carla Cristine Neves Mamede, Nadia Cristina Gomes de Morais, Kelly Cortes Fonseca, Bruna Barbosa de Sousa, Thaís M. Migliorini, Déborah Fernanda C. Pereira, Leonilda Stanziola, Leonardo A. Calderón, Rodrigo Simões‐Silva, Andreimar M. Soares, Fábio de Oliveira   +11 more
openalex   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Hirudins and fenestrins of the African medicinal leech Asiaticobdella fenestrata. [PDF]

Parasitol Res
Schulz L, Tolksdorf C, Rauch BH, Kvist S, Müller C.   +4 more
europepmc   +1 more source

2-Arylmethyl-1,4-benzoquinones. II. Novel Inhibitors of Platelet Aggregation: Synthesis and Pharmacological Evaluation.

, 1997
Kenji Suzuki, Toshio Tatsuoka, Takafumi Ishihara, Ryoko Ogino, Tomoko MIYAZAKI, Fumio Satoh, S. MIYANO, Kunihiro SUMOTO   +7 more
openalex   +2 more sources

ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF‐1, MDC and TARC [PDF]

, 2001
Sudawadee Suttitanamongkol, A R L Gear
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Bioactivity-Guided Fractionation of Dragon's Blood Phenolic Extracts Reveals Loureirin D as a P2Y12 Inhibitor Mediating Antiplatelet Effects. [PDF]

Int J Mol Sci
Peng J, Wang P, Chen Y, Liao X, Guo H, Zhang P, Zhang J.   +6 more
europepmc   +1 more source

Investigation on the mechanisms of action of aprotinin in cardiac surgery [PDF]

, 1991
Baranky, A., Dietrich, W., Friedel, N., Hetzer, P., Jochum, Marianne, Richter, J. A., Royston, D., Spannagl, Michael, Wendt, P.   +8 more
core   +1 more source

Pyridazines. XIII. Synthesis of 6-aryl-5-oxygenated substituted-3(2H)-pyridazinones and evaluation as platelet aggregation inhibitors.

Chemical and pharmaceutical bulletin, 1997
R. Laguna, B. Rodríguez-Liñares, E. Cano, I. Estevez, E. Raviña, E. Sotelo   +5 more
semanticscholar   +1 more source