Results 231 to 240 of about 47,830 (314)

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Ubiquitous clot contraction blockers hit ubiquitin and more. [PDF]

Blood Adv
Weisel JW, Litvinov RI.
europepmc   +1 more source

Polyamines Inhibit Both Platelet Aggregation and Glycoprotein IIb/IIIa Activation

, 2005
Norma Corona-de-la-Peña, Salvador Uribe‐Carvajal, Rehotbeverly Barrientos-Rios, Lisnet Matias-Aguilar, Guadalupe Montiel-Manzano, Abraham Majluf‐Cruz   +5 more
openalex   +1 more source

Binding of a novel platelet aggregation inhibitor to human platelet actin

Japanese Journal of Pharmacology, 1982
Yukio Kimura, Toshio Tanaka, Hideaki Kohri, Hayato Umekawa, Kozo Watanabe, Hiroyoshi Hidaka   +5 more
openaire   +2 more sources

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Advances in the comprehensive mechanisms, diagnosis, and treatment of heatstroke-induced coagulopathy. [PDF]

Front Cell Dev Biol
Xiang C, Gao L, Liu X, Xiang J, Zhu B, Fu S, Zhao J, Song Q.   +7 more
europepmc   +1 more source

TPA-induced platelet aggregation and its inhibitors

Japanese Journal of Pharmacology, 1984
Kenji Kanamaru, Hiroyoshi Hidaka, Toshiyuki Yamakado   +2 more
openaire   +2 more sources

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Impact of Tirofiban and Cilostazol on Cardiac Recovery in Elderly Patients with Acute Coronary Syndrome. [PDF]

Med Sci Monit
Hu Y, Chen L, Zhu L, Xu T, Chen Q, Qian Z, Wang L.   +6 more
europepmc   +1 more source