Novel adenovirus vaccine vectors lacking thrombosis-associated interactions with platelet factor 4 [PDF]
iScienceSummary: The adenoviral vector-based AstraZeneca and Janssen COVID-19 vaccines have been associated with rare cases of thrombosis, believed to be triggered, among other factors, by vector binding to the blood protein platelet factor 4 (PF4).
Erwan Sallard +31 more
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Platelet factor 4 and stromal cell-derived factor are novel prognostic biomarkers for cerebral vasospasm and mortality after subarachnoid hemorrhage [PDF]
Scientific ReportsAneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition associated with high rates of morbidity and mortality, mainly due to post-hemorrhagic complications such as cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI).
Dilaware Khan +5 more
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Interactions of marine sulfated glycans with antithrombin and platelet factor 4 [PDF]
Frontiers in Molecular Biosciences, 2022 The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and heparin induced thrombocytopenia (HIT).
Wenjing Zhang +6 more
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Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. [PDF]
PLoS ONE, 2010 Cerebral malaria continues to be a difficult to treat complication of Plasmodium falciparum infection in children. We have shown that platelets can have major deleterious immune functions in experimental cerebral malaria (ECM).
Kalyan Srivastava +4 more
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Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts [PDF]
Scientific Reports, 2022 Periodontitis is a chronic inflammatory disease characterized by the release of matrix metalloproteinases (MMPs) from resident connective tissue cells in tooth-supporting tissues (periodontium).
Hoa T. Le +10 more
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Platelet Factor 4: A Mysterious Chemokine in Inflammatory Regulation Diseases [PDF]
Journal of Inflammation ResearchYibing Ji,1,* Qian Zhang,2,* Hua Li,3,* Lixia Chen,3 Yuzhuo Wu,4 Sheng Lin1,2 1College of Pharmacy, Shandong Second Medical University, Weifang, Shandong, 261053, People’s Republic of China; 2Key Laboratory of Chinese Internal Medicine of ...
Ji Y, Zhang Q, Li H, Chen L, Wu Y, Lin S
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Platelet factor 4 induces bone loss by inhibiting the integrin α5‐FAK‐ERK pathway [PDF]
Animal Models and Experimental Medicine, 2023 Background The effect of platelet factor 4 (PF4) on bone marrow mesenchymal stem cells (BMMSCs) and osteoporosis is poorly understood. Therefore, this study aimed to evaluate the effects of PF4‐triggered bone destruction in mice and determine the ...
Wei Li +4 more
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Allergology International, 2008 Background: Beyond their role in hemostasis and thrombosis, platelets are important for modulating inflammatory reactions. Activated platelets play a role in the pathomechanism of inflammatory diseases such as asthma, but little is known about platelet ...
Risa Tamagawa-Mineoka +4 more
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Platelet Factor 4 Antibodies and Severe AKI. [PDF]
Kidney360, 2023 Key Points Patients testing positive for platelet factor 4 antibodies have a >50% higher odds of developing severe AKI compared with those who test negative.The relationship between platelet factor 4 antibodies and severe AKI was independent of demographics, comorbidities, laboratory values,
Thomas C +11 more
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Anti-Platelet factor 4 immunothrombosis—not just heparin and vaccine triggers [PDF]
Research and Practice in Thrombosis and HaemostasisDerailments at the tightly regulated interface of blood coagulation and innate inflammatory immune responses can lead to pathologic immunothrombosis. A special subset of immunothrombosis is caused by antibodies against platelet-factor 4 (PF4).
Luisa Müller +4 more
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