Results 11 to 20 of about 629,196 (341)

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders [PDF]

Advanced Science
Vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a new disorder that emerged in the wake of coronavirus disease 2019 (COVID‐19) vaccination.
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
doaj   +2 more sources

The disparity of platelet factor 4 and platelets in individuals of different ages [PDF]

Heliyon
The aging process profoundly impacts the systemic milieu, with specific blood-borne factors playing critical roles in its regulation. Platelet Factor 4 (PF4), released by platelets, has emerged as a novel blood-borne factor that contributes to the ...
Ruopeng Weng, Jiaqing Liu, Qingtan Yu, Haitao Yuan, Yun Qiu, Huicong Liu, Lingna Wang, Zijie Mei, Fangfang Zhu   +8 more
doaj   +2 more sources

In platelet single donor apheresis, platelet factor 4 levels correlated with donor’s age and decreased during storage [PDF]

Scientific Reports
The human population is ageing worldwide. The World Health Organization estimated that the world’s population of people aged 60 years and older will increase to at least 30%, coinciding with a growing frequency of cognitive and cardiovascular disease ...
Anne Claire Duchez, Marco Heestermans, Charles-Antoine Arthaud, Marie-Ange Eyraud, Mailys Portier, Amélie Prier, Hind Hamzeh-Cognasse, Fabrice Cognasse   +7 more
doaj   +2 more sources

Classification of Platelet-Activating Anti-Platelet Factor 4 Disorders. [PDF]

Int J Lab Hematol
ABSTRACTIntroductionThe prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Warkentin TE.
europepmc   +3 more sources

Anti‐platelet factor 4/heparin antibodies in patients with Hantaan virus infection [PDF]

Research and Practice in Thrombosis and Haemostasis, 2022
Background Hemorrhagic fever with renal syndrome (HFRS) induced by Hantaan virus infection and heparin‐induced thrombocytopenia (HIT) are associated with symptoms such as thrombocytopenia and thrombosis.
Meng Wang, Chun‐mei Zhang, Ying Ma, Kang Tang, Xi‐yue Zhang, Xiao‐zhou Jia, Hai‐feng Hu, Ran Zhuang, Bo‐quan Jin, Yu‐si Zhang, Yun Zhang   +10 more
doaj   +2 more sources

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice [PDF]

Nature Communications, 2023
The beneficial effects of physical activity on brain ageing are well recognised, with exerkines, factors that are secreted into the circulation in response to exercise, emerging as likely mediators of this response.
Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda, Tara L. Walker   +12 more
doaj   +2 more sources

Monoclonal Anti-Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss. [PDF]

N Engl J Med
Bavli NR, Kanack AJ, Nishimura Y, Splinter NP, Mauch EE, Ainsworth AJ, Sarode R, McBane RD, Kohlhagen MC, Murray D, Chen D, Pruthi RK, Padmanabhan A.   +12 more
europepmc   +3 more sources

Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4 [PDF]

Communications Biology
Heparin-induced thrombocytopenia (HIT) is an adverse reaction to heparin leading to a reduction in circulating platelets with an increased risk of thrombosis.
Yang Yang, Yi Du, Daniil Ivanov, Chendi Niu, Rumi Clare, James W. Smith, Ishac Nazy, Igor A. Kaltashov   +7 more
doaj   +2 more sources

The complicated relationships of heparin-induced thrombocytopenia and platelet factor 4 antibodies with COVID-19. [PDF]

Int J Lab Hematol, 2021
Favaloro EJ, Henry BM, Lippi G.
europepmc   +3 more sources

Blood platelet factor 4: the elixir of brain rejuvenation [PDF]

Molecular Neurodegeneration
José M. Izquierdo
doaj   +2 more sources