Results 21 to 30 of about 629,196 (341)

Insights into platelet factor 4-derived peptide macrocycles; the mechanistic basis of their rapid and selective antiplasmodial actions. [PDF]

Cell Mol Life Sci
Xu DW, Raven K, Woodcock SR, Munro B, Palombi IR, Gare CL, White AM, Malins LR, Lawrence N, McMorran BJ.   +9 more
europepmc   +3 more sources

Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro.

PLoS ONE, 2021
Galectin-1 (gal-1) is a carbohydrate-binding lectin with important functions in angiogenesis, immune response, hemostasis and inflammation. Comparable functions are exerted by platelet factor 4 (CXCL4), a chemokine stored in the α-granules of platelets ...
Annemiek Dickhout, Bibian M E Tullemans, Johan W M Heemskerk, Victor L J L Thijssen, Marijke J E Kuijpers, Rory R Koenen   +5 more
doaj   +1 more source

Platelet factor 4 (PF4; CXCL4) [PDF]

Science-Business eXchange, 2012
openaire   +2 more sources

An affinity-based method for the purification of platelet factor 4 from outdated platelet concentrates [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  Platelet factor 4 (PF4) is considered as a chemokine mainly strode in the granules of platelets. Its important role in heparin-induced thrombocytopenia (HIT) was the basis of many investigations about this chemokine.
Alireza Goodarzi, Fatemeh Yari, Mahshid Mohammadipour   +2 more
doaj  

Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system

Cardiovascular Diabetology, 2022
Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation
Arneaux Kruger, Mare Vlok, Simone Turner, Chantelle Venter, Gert Jacobus Laubscher, Douglas B. Kell, Etheresia Pretorius   +6 more
doaj   +1 more source

Lipolysis generates platelet dysfunction after in vivo heparin administration [PDF]

, 2002
Heparin, when administered to patients undergoing operations using cardiopulmonary bypass, induces plasma changes that gradually impair platelet macroaggregation, but heparinization of whole blood in vitro does not have this effect.
Belcher, P.R., Caslake, M.J., Chaudhry, M.A., Day, S., Muriithi, E.W., Wheatley, D.J.   +5 more
core   +1 more source

Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia

Thrombosis Journal, 2021
Background This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain coronavirus vaccines.
Payel Datta, Fuming Zhang, Jonathan S. Dordick, Robert J. Linhardt   +3 more
doaj   +1 more source

Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis

Frontiers in Veterinary Science, 2022
ObjectiveSeptic peritonitis is associated with significant morbidity and mortality. As a potential therapeutic agent in the treatment of sepsis, 2-O, 3-O desulfated heparin (ODSH) reduces histones and platelet factor 4 (PF4) in mouse sepsis models.
Katie D. Mauro, Michele P. Lambert, M. Anna Kowalska, Vincent J. Thawley, Mortimer Poncz, Cynthia M. Otto   +5 more
doaj   +1 more source

Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants [PDF]

, 2019
To establish a method that allows for the reliable assessment of vascular endothelial growth factor (VEGF-A) concentrations in very small blood samples of preterm infants. Systemic VEGF measurements are important in view of the most appropriate Anti-VEGF
Lopez Yomayuza, Claudia C., Lorenz, Birgit, Preissner, Klaus T., Stieger, Knut   +3 more
core   +1 more source

Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP. [PDF]

, 2017
Platelet activation in response to stimulation of the Protease Activated Receptor 4 (PAR4) receptor differs by race. One factor that contributes to this difference is the expression level of Phosphatidylcholine Transfer Protein (PCTP), a regulator of ...
Bray, Paul F., Edelstein, Leonard C., Holinstat, Michael, Kong, Xianguo, Shaw, Chad A., Simon, Lukas M.   +5 more
core   +3 more sources