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Seminars in Thrombosis and Hemostasis, 2016 Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate endpoints of efficacy of new antiplatelet therapy, and to an extent, in the monitoring of antiplatelet ...
Marie Lordkipanidzé +1 more
openaire +6 more sources
Platelet function tests: a comparative review [PDF]
Vascular Health and Risk Management, 2015 In physiological hemostasis a prompt recruitment of platelets on the vessel damage prevents the bleeding by the rapid formation of a platelet plug. Qualitative and/or quantitative platelet defects promote bleeding, whereas the high residual reactivity of platelets in patients on antiplatelet therapies moves forward thromboembolic complications.
PANICCIA, RITA +3 more
core +10 more sources
Antiplatelet Therapy and Platelet Function Testing [PDF]
Clinical Cardiology, 2008 Eugene Braunwald,∗ Dominick Angiolillo,† Eric Bates,‡ Peter B. Berger,§ Deepak Bhatt,|| Christopher P. Cannon,∗ Mark I. Furman,¶ Paul Gurbel,∗∗ Alan D. Michelson,†† Eric Peterson,‡‡ Stephen Wiviott∗ ∗TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts ...
Eugene Braunwald +10 more
openalex +8 more sources
State of the Art in Platelet Function Testing [PDF]
Transfusion Medicine and Hemotherapy, 2013 Platelets perform many functions in hemostasis but also in other areas of physiology and pathology. Therefore, it is obvious that many different function tests have been developed, each one conceived and standardized for a special purpose. This review will summarize the different fields in which platelet function testing is currently in use ...
Beate E. Kehrel, Martin F. Brodde
openalex +4 more sources
Assay validity of point-of-care platelet function tests in thrombocytopenic blood samples [PDF]
, 2022 Point-of-care (POC) platelet function tests are faster and easier to perform than in-depth assessment by flow cytometry. At low platelet counts, however, POC tests are prone to assess platelet function incorrectly. Lower limits of platelet count required
Eichelberger, Beate +6 more
core +2 more sources
Platelet function testing : Current practice among clinical centres in Northern Europe [PDF]
, 2022 Introduction Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before ...
Kärkkäinen, Satu +5 more
core +1 more source
Platelet Phenotyping and Function Testing in Thrombocytopenia [PDF]
Journal of Clinical Medicine, 2021 Patients who suffer from inherited or acquired thrombocytopenia can be also affected by platelet function defects, which potentially increase the risk of severe and life-threatening bleeding complications. A plethora of tests and assays for platelet phenotyping and function analysis are available, which are, in part, feasible in clinical practice due ...
Kerstin Jurk, Yavar Shiravand
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Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. [PDF]
, 2023 Factor XIII (FXIII) is an important proenzyme in the hemostatic system. The plasma-derived enzyme activated FXIII cross-links fibrin fibers within thrombi to increase their mechanical strength and cross-links fibrin to fibrinolytic inhibitors ...
Bastos, Ricardo N. +17 more
core +2 more sources
Sensitivity of Viscoelastic Tests to Platelet Function [PDF]
Journal of Clinical Medicine, 2020 Viscoelastic tests provide a dynamic assessment of coagulation, by exploring the time to clot formation and the clot strength. Using specific activators or inhibitors, additional factors can be explored, like the fibrinogen contribution to clot strength.
Ekaterina Baryshnikova, Marco Ranucci
openaire +3 more sources
Immersed boundary simulations of cell-cell interactions in whole blood [PDF]
, 2021 We present a new method for the geometric reconstruction of elastic surfaces simulated by the immersed boundary method with the goal of simulating the motion and interactions of cells in whole blood. Our method uses parameter-free radial basis functions for high-order meshless parametric reconstruction of point clouds and the elastic force computations
arxiv +1 more source