Results 51 to 60 of about 764,489 (264)

Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients [PDF]

, 2019
Background: a higher risk of atherothrombotic cardiovascular events, which are platelet-driven processes, has been described during acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Cequier Fillat, Àngel R., Dorca i Sargatal, Jordi, Ferreiro, José Luis, Gómez Hospital, Joan Antoni, Huertas, David, López Sánchez, Marta, Marcano, Ana Lucrecia, Muñoz Esquerre, Mariana, Roura, Gerard, Santos Pérez, Salud   +9 more
core   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

Platelets of patients with chronic kidney disease demonstrate deficient platelet reactivity in vitro [PDF]

, 2012
Background In patients with chronic kidney disease studies focusing on platelet function and properties often are non-conclusive whereas only few studies use functional platelet tests.
A Aggarwal, AJ Collins, AS Go, C Stumpf, Carlo A Gaillard, D Kaw, Daisy Walter, DI Jalal, DR Rios, DW Cockcroft, ER van Bladel, Esther R van Bladel, JJ Zwaginga, JJ Zwaginga, K Dickstein, K Nitta, K van der Putten, Leonie A Boven, LF Casserly, LF Fried, Loes Cornelissen, M Noris, M Schoorl, Mark Roest, MJ Sarnak, P Muntner, PA Kyrle, RM Henry, Rob Fijnheer, Rosa L de Jager, SC Palmer, V Moal   +31 more
core   +3 more sources

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Depletion potential in colloidal mixtures of hard spheres and platelets [PDF]

, 2004
The depletion potential between two hard spheres in a solvent of thin hard disclike platelets is investigated by using either the Derjaguin approximation or density functional theory. Particular attention is paid to the density dependence of the depletion potential.
arxiv   +1 more source

In Vitro and In Vivo Assessment of Platelet Function in Healthy Dogs during Low-Dose Aspirin Therapy [PDF]

, 2014
Low-dose aspirin therapy in dogs inconsistently inhibits platelet function, termed ‘aspirin resistance’. There are no established diagnostic tests that can predict aspirin resistance in dogs prior to therapy.
Haines, Jillian Marie
core   +1 more source

High residual platelet reactivity during aspirin therapy in patients with non-st segment elevation acute coronary syndrome: Comparison between initial and late phases [PDF]

, 2019
Background: High platelet reactivity (HPR) during therapy with acetylsalicylic acid (ASA) is a poor prognostic factor in acute coronary syndromes (ACS). The prevalence of HPR during ACS is greater than that reported in stable diseases.
H.S. Martins, J.C. Nicolau, M. Cattaneo, M.D.A. Dracoulakis, P. Gurbel, R.K. Filho   +5 more
core   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Bulk and wetting phenomena in a colloidal mixture of hard spheres and platelets [PDF]

, 2004
Density functional theory is used to study binary colloidal fluids consisting of hard spheres and thin platelets in their bulk and near a planar hard wall. This system exhibits liquid-liquid coexistence of a phase that is rich in spheres (poor in platelets) and a phase that is poor in spheres (rich in platelets). For the mixture near a planar hard wall,
arxiv   +1 more source