Results 141 to 150 of about 102,308 (347)

Unexpected Remyelination in the Absence of Matrix Metalloproteinase 7

Glia, EarlyView.
MMP7 is not essential for demyelination and remyelination in the cuprizone model. In MMP7−/− mice fibronectin aggregates do not accumulate in the remyelination phase. MMP7−/− mice have lower levels of fibronectin and hyaluronan after chronic demyelination.
Rianne P. Gorter, Andrea J. Arreguin, Wendy Oost, Jenny C. de Jonge, Harm H. Kampinga, Sandra Amor, Holly Colognato, Wia Baron   +7 more
wiley   +1 more source

Nix-mediated mitophagy regulates platelet activation and life span

Blood Advances, 2019
: Platelet activation requires fully functional mitochondria, which provide a vital energy source and control the life span of platelets. Previous reports have shown that both general autophagy and selective mitophagy are critical for platelet function ...
Weilin Zhang, Qi Ma, Sami Siraj, Paul A. Ney, Junling Liu, Xudong Liao, Yefeng Yuan, Wei Li, Lei Liu, Quan Chen   +9 more
doaj  

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, EarlyView.
Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain. ABSTRACT Astrocytes are the most abundant glial cell type in the central nervous system (CNS).
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

Cultured human endothelial cells synthesize a plasma membrane protein complex immunologically related to the platelet glycoprotein IIb/IIIa complex [PDF]

, 1986
O. C. Leeksma, J Zandbergen-Spaargaren, JC Giltay, JA van Mourik   +3 more
openalex   +3 more sources

Perfect Absorption Metasurfaces with Multiple Meta-Resonances [PDF]

arXiv, 2019
We show that the hybrid resonances of a DMR backed by a cavity are meta-resonances, in that they can be made as perfect as possible by fine tuning the structural parameters but without the requirements of extreme materials properties, such as zero dissipation.
arxiv  

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

PROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An, Dries S. Martens, Gontse G. Mokwatsi, Yu‐Ling Yu, Babangida S. Chori, Agnieszka Latosinska, Godsent Isiguzo, Susanne Eder, Dong‐Yan Zhang, Gert Mayer, Ruan Kruger, Jana Brguljan‐Hitij, Christian Delles, Catharina M. C. Mels, Katarzyna Stolarz‐Skrzypek, Marek Rajzer, Peter Verhamme, Aletta E. Schutte, Tim S. Nawrot, Yan Li, Harald Mischak, Augustine N. Odili, Jan A. Staessen   +22 more
wiley   +1 more source

Hetrombopag: A promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia

Rheumatology &Autoimmunity, EarlyView.
This review seeks to provide a thorough synthesis of the existing literature on the role of thrombopoietin receptor agonists in the treatment of primary and secondary immune thrombocytopenia, with particular emphasis on the compound Hetrombopag. Abstract Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by a platelet count below
Jiaqi Hu, Zhida Fu, Xia Xu, Zhengyi Jin, Xinyu Qian, Weiyu Tao, Taiyan Ma, Dongbao Zhao, Jie Gao   +8 more
wiley   +1 more source

Quantitation of membrane glycoprotein IIIa on intact human platelets using the monoclonal antibody, AP-3 [PDF]

, 1985
PJ Newman, Allen Rw, RA Kahn, TJ Kunicki
openalex   +1 more source

High-Fidelity Description of Platelet Deformation Using a Neural Operator [PDF]

arXiv
The goal of this work is to investigate the capability of a neural operator (DeepONet) to accurately capture the complex deformation of a platelet's membrane under shear flow. The surrogate model approximated by the neural operator predicts the deformed membrane configuration based on its initial configuration and the shear stress exerted by the blood ...
arxiv  

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source