Results 141 to 150 of about 19,640 (272)

Orosomucoid 1 Participates in Alveolar Hypercoagulation and Fibrinolytic Inhibition Involving NF‐κB Signaling Pathway in LPS‐Induced ARDS

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
ORM1 promotes LPS‐induced ARDS by activating NF‐κB in alveolar epithelial II cells, upregulating TF/PAI‐1 to cause hypercoagulation and fibrinolysis inhibition, leading to lung injury. ORM1 knockdown reverses these effects, indicating therapeutic potential.
Xianjun Chen, Ying Liu, Song Mu, Tingting Chen, Jia Yuan, Chuan Xiao, Qi Dong, Qing Li, Ying Wang, Qimin Chen, Shuwen Li, Wei Li, Feng Shen   +12 more
wiley   +1 more source

Artificial microvascular graft thrombosis: the consequences of platelet membrane glycoprotein Ib inhibition and thrombin inhibition [PDF]

, 1993
WH Dascombe, Chull Hong, KO Garrett, JG White, VA Lyle, JL Miller, PC Johnson   +6 more
openalex   +1 more source

Two Sides of the Same Coin—Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Extracellular vesicles (EVs) have gained increasing attention in recent years due to their pivotal role in both health and disease. Emerging from both eukaryotic and prokaryotic cells, EVs serve as essential mediators of intercellular communication, exceeding the simplistic interactions observed with individual molecules. In this comprehensive
Philipp Arnold, Fanni Annamária Boros, Jochen Mattner, Gerald Seidel, Chaofan Liu, Inga Viktoria Hensel, Jan Van Deun, Raphael Schwendner, Janina Müller‐Deile, Nina Sopel, Andreas Ramming, Mario R. Angeli, Simon Rauber, Cláudia Vilhena, Andreas Baur, Stefan Wirtz, Klaus Überla, Heiko Reutter, Linda‐Marie Mulzer, Alina C. Hilger, Friederike Zunke, Wei Xiang, Gregor Fuhrmann, Claudia Günther   +23 more
wiley   +1 more source

Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance

MedComm, Volume 6, Issue 11, November 2025.
This graphical abstract illustrates the immunomodulation of chronic wounds through various therapeutic approaches aimed at regulating the immune response to promote healing. ABSTRACT Chronic wounds—such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)—pose a serious clinical challenge due to their prolonged ...
Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar, Thomas Biedermann   +3 more
wiley   +1 more source

Thrombospondin-platelet interactions. Role of divalent cations, wall shear rate, and platelet membrane glycoproteins. [PDF]

, 1993
F R Agbanyo, J J Sixma, Philip G. de Groot, Lucia R. Languino, Edward F. Plow   +4 more
openalex   +1 more source

Cancer‐Associated Fibroblasts: Origin, Classification, Tumorigenicity, and Targeting for Cancer Therapy

MedComm, Volume 6, Issue 11, November 2025.
This review explores the multifaceted roles of cancer‐associated fibroblasts (CAFs) in tumor biology. It examines their diverse origins, dynamic activation via signaling pathways, and spatial–temporal heterogeneity, proposing an updated classification of eight distinct CAF subtypes. The review highlights CAFs' contributions to tumor growth, metastasis,
Chang Fan, Wenlong Zhu, Yuan Chen, Wanwan Zhu, Jin Ding   +4 more
wiley   +1 more source

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, Volume 62, Issue 9, Page 901-919, November 2025.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source

Selatogrel: Potential to redefine timely anti‐platelet intervention

British Journal of Pharmacology, Volume 182, Issue 22, Page 5435-5452, November 2025.
Acute coronary syndrome (ACS) encompasses a number of heart diseases that cause a sudden decrease in coronary perfusion, precipitating cardiomyocyte necrosis or heightened risk thereof. This pathology is a major burden of cardiovascular disease.
Rudy N. Zalzal, Peter P. Salem, Ali H. Dakroub, Ali H. Eid   +3 more
wiley   +1 more source

Effect of Valemetostat on the Pharmacokinetics of Midazolam and Digoxin: A Phase 1 Drug–Drug Interaction Study in Patients With Non‐Hodgkin Lymphoma

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH)2/1, under investigation in non‐Hodgkin lymphomas (NHLs) and solid tumors. In vitro, it inhibits cytochrome P450 3A (CYP3A) and P‐glycoprotein (P‐gp) when combined with sensitive CYP3A or P‐gp substrates.
Masaya Tachibana, Steven Horwitz, Eric Jacobsen, Francine Foss, Pamela Allen, Pierluigi Porcu, Tatyana Feldman, Jia Ruan, Jonathan E. Brammer, Jie Wang, Shinichi Inaba, Yuka Iko, Keiko Nakajima, Yasuyuki Kakurai, Noriaki Kitami, Yang Chen, Yvonne Lau   +16 more
wiley   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1383-1408, November 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16431 Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment.
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source