Results 191 to 200 of about 17,608 (289)

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Cancer‐associated fibroblasts (CAFs) arise from normal fibroblasts in response to various tumor microenvironmental signals, including cytokines such as TGF‐β and IL‐6, paracrine factors like PDGFs, Notch signaling, extracellular vesicles, as well as aging, inflammation, hypoxia, oxidative stress, and increased extracellular matrix (ECM) stiffness. Upon
Yutao Li, Qingyun Liu, Xilin Jing, Yuqi Wang, Xiaohua Jia, Xing Yang, Kezhong Chen   +6 more
wiley   +1 more source

Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway. [PDF]

Front Pharmacol
Shi S, Gao J, Zhang Y, Zhan M, Tan Z, Wang P, Fu J, Liu J.   +7 more
europepmc   +1 more source

The Transmembrane Domains of β and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain

, 2015
Guofeng Xu, Dan Shang, Zuping Zhang, Tanner S. Shaw, Yali Ran, José A. López, Yuandong Peng   +6 more
openalex   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, Volume 6, Issue 7, July 2025.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source

Severe Thrombocytopenia Secondary to Babesiosis: A Case Report. [PDF]

Case Rep Hematol
Cirra VR, Kommu S, Husak M, Osterbauer C.   +3 more
europepmc   +1 more source

Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia

, 2015
Zhanwen Huang, Wenjun Liu, Qulian Guo, CHUN-YAN LIU   +3 more
openalex   +1 more source

Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis

Brain Pathology, Volume 35, Issue 4, July 2025.
Graphical representation of the widespread white matter (blue color mask) and grey matter (cortical and deep grey matter; red color mask) demyelination in MS cases characterized by substantial inflammation of the CP (A). The presence of lesions was mainly associated with periventricular white matter and hippocampus areas (A).
R. Magliozzi, S. Hametner, M. Mastantuono, A. Mensi, M. Karimian, L. Griffiths, L. M. Watkins, A. Poli, G. M. Berti, E. Barusolo, B. Bellini, S. Rossi, D. Gveric, J. A. Stratton, K. Akassoglou, S. Magon, R. Nicholas, R. Reynolds, O. W. Howell, S. Monaco   +19 more
wiley   +1 more source

Transient Platelet Satellitism and Cellular Phagocytosis Associated With Type A Influenza Virus Infection: A Case Report. [PDF]

Cureus
Tsiatsiou P, Tsaireli V, Makris M, Kaiafa G, Skoura L.   +4 more
europepmc   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Transmembrane thiol isomerase TMX1 inhibits fibrin formation by down-regulation of platelet phosphatidylserine exposure. [PDF]

Cell Commun Signal
Zhao Z, Zhang Y, Cheng Y, Chen X, Lu Y, Han Y, Wu Y, Yang A.   +7 more
europepmc   +1 more source