Results 191 to 200 of about 102,308 (347)

Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy.

open access: yesJournal of Biological Chemistry, 1985
N. Carrell   +4 more
semanticscholar   +1 more source

Natural products targeting tumour angiogenesis

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu   +2 more
wiley   +1 more source

Involvement of Piezo 1 in inhibition of shear‐induced platelet activation and arterial thrombosis by ginsenoside Rb1

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 9, Page 1957-1974, May 2025.
Abstract Background and Purpose Shear‐induced platelet activation and aggregation (SIPA) play crucial roles in arterial thrombosis. Piezo1 is a mechanosensitive calcium channel that promotes platelet hyperactivation under pathological high‐shear conditions.
Yilin Wang   +8 more
wiley   +1 more source

Assessment of Spinster homologue 2 (Spns2)‐dependent transport of sphingosine‐1‐phosphate as a therapeutic target

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 9, Page 2014-2030, May 2025.
Abstract Background and Purpose Sphingosine‐1‐phosphate (S1P) receptor modulator (SRM) drugs suppress immune system function by disrupting lymphocyte trafficking, but SRMs are broadly immunosuppressive with on‐target liabilities. Another strategy to modulate the immune system is to block S1P transport.
Yugesh Kharel   +17 more
wiley   +1 more source

Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2647-2657, May 2025.
Abstract Objective Roux‐en‐Y gastric bypass (RYGB) surgery has been shown to lead to favourable health outcomes in obese patients. However, the molecular changes that occur and how they relate to clinical measures are poorly understood. Here, we characterise the proteomic alterations that occur in plasma of RYGB patients before and 9 months after ...
Hasnain Ahmed   +6 more
wiley   +1 more source

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