Results 231 to 240 of about 102,308 (347)

The Peptide PROTAC Modality: A New Strategy for Drug Discovery

MedComm, Volume 6, Issue 4, April 2025.
Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
wiley   +1 more source

The Transmembrane Domains of β and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain

, 2015
Guofeng Xu, Dan Shang, Zuping Zhang, Tanner S. Shaw, Yali Ran, José A. López, Yuandong Peng   +6 more
openalex   +1 more source

Antibody‐Nanoparticle Conjugates in Therapy: Combining the Best of Two Worlds

Small, Volume 21, Issue 15, April 16, 2025.
Antibody‐nanomaterial conjugates (ANCs) are an emerging therapeutic class combining the precise targeting specificity of antibodies with the versatility and functionality of nanomaterials. This review summarizes ANC design, synthesis, and potential therapeutic applications in this rapidly advancing field.
Aniruddha Adhikari, Irene A. Chen
wiley   +1 more source

Dengue Fever in an Adult Presenting as Immune Thrombocytopenic Purpura (ITP): A Case Report. [PDF]

Cureus
Sahoo D, Dey A, Bandyopadhyay TS, Devi S, Dalei S.   +4 more
europepmc   +1 more source

Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia

, 2015
Zhanwen Huang, Wenjun Liu, Qulian Guo, CHUN-YAN LIU   +3 more
openalex   +1 more source

Systemic lupus erythematosus‐associated autoantibodies in sickle cell disease: Spontaneous emergence in a patient and in transgenic sickle mice

British Journal of Haematology, Volume 206, Issue 4, Page 1213-1217, April 2025.
Summary We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi‐organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic
Urshita Sinha, Suman Setty, Céleste Pilon, Julia J. Brown, Maria Armila Ruiz, Guohui Ren, Joyce Rauch, Santosh L. Saraf, Jerrold S. Levine   +8 more
wiley   +1 more source

Desialylation and Apoptosis in Immune Thrombocytopenia: Implications for Pathogenesis and Treatment. [PDF]

Curr Issues Mol Biol
Zheng SS, Perdomo JS.
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review

British Journal of Pharmacology, Volume 182, Issue 7, Page 1416-1445, April 2025.
Abstract In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new chemical entities were approved, the number of ‘orphan’ drug authorisations in 2024 (21) is ...
Stavros Topouzis, Andreas Papapetropoulos, Steve P. H. Alexander, Miriam Cortese‐Krott, Dave A. Kendall, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Mauro M. Teixeira, Nathalie Vergnolle, Xin Wang, Péter Ferdinandy   +16 more
wiley   +1 more source

Tanfloc-Modified Titanium Surfaces: Optimizing Blood Coagulant Activity and Stem Cell Compatibility. [PDF]

ACS Biomater Sci Eng
Singh R, Madruga LYC, Savargaonkar A, Martins AF, Kipper MJ, Popat KC.   +5 more
europepmc   +1 more source

Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis.

, 1977
David R. Phillips, Patricia Poh Agin
openalex   +1 more source