Results 1 to 10 of about 3,755 (143)

Plectin: Dual Participation in Tumor Progression [PDF]

Biomolecules
The plectin gene can encode a cytoskeletal linking protein, plectin, known for its interaction with three critical components of the cellular cytoskeleton: intermediate filaments, microtubules, and actin filaments.
Zhihui Wang, Wenbin Wang, Qing Luo, Guanbin Song   +3 more
doaj   +4 more sources

The Role of Plectin Dysregulation in Cancer: Recent Advances [PDF]

Molecules
Plectin is a key cytolinker protein that functions as an integrator of the cytoskeletal networks by crosslinking intermediate filaments with actin filaments and microtubules.
Wenbin Wang, Chang Lyu, Zhihui Wang, Xu Zhang, Qing Luo, Guanbin Song   +5 more
doaj   +2 more sources

Unraveling the Oncogenic Characteristics of the Cytolinker, Plectin, in Esophageal Squamous Cell CarcinomaSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Tissue mechanics involved in carcinogenesis by regulating cell morphology and structure, cell-cell, and cell-extracellular matrix (ECM) interactions are not fully understood.
Lili Qiao, Yuanyuan Hu, Lei Xu, Guodong Deng, Xiaohong Yu, Wei Zheng, Yanan Yang, Hui Yuan, Wei Jiang, Xiying Yu   +9 more
doaj   +2 more sources

Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migration [PDF]

iScience
Summary: Triple-negative breast cancer (TNBC) lacks targeted therapeutics and is aggressive with a poor prognosis. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, frequently deregulated in cancers, plays crucial roles in tumorigenesis and
Shixue Zheng, Chloe Chan, John M. Asara, Liang Zhang, Gerhard Wiche, Y. Rebecca Chin   +5 more
doaj   +2 more sources

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis [PDF]

eLife
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor
Zuzana Outla, Gizem Oyman-Eyrilmez, Katerina Korelova, Magdalena Prechova, Lukas Frick, Lenka Sarnova, Piyush Bisht, Petra Novotna, Jan Kosla, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Mohammad Rahbari, Nuh Rahbari, Emrullah Birgin, Bibiana Kvasnicova, Andrea Galisova, Katerina Sulkova, Andreas Bauer, Njainday Jobe, Ondrej Tolde, Eva Sticova, Daniel Rösel, Tracy O'Connor, Martin Otahal, Daniel Jirak, Mathias Heikenwälder, Gerhard Wiche, Samuel M Meier-Menches, Martin Gregor   +30 more
doaj   +2 more sources

High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis [PDF]

BMC Biology
Background Abundant research indicates that increased extracellular matrix (ECM) stiffness significantly enhances the malignant characteristics of hepatocellular carcinoma (HCC) cells.
Zhihui Wang, Wenbin Wang, Qing Luo, Guanbin Song   +3 more
doaj   +2 more sources

Impaired Autophagic Flux in Skeletal Muscle of Plectin‐Related Epidermolysis Bullosa Simplex With Muscular Dystrophy [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Plectin, a multifunctional cytolinker and intermediate filament stabilizing protein, is essential for muscle fibre integrity and function. Mutations in the human plectin gene (PLEC) cause autosomal recessive epidermolysis bullosa simplex with ...
Michaela M. Zrelski, Margret Eckhard, Petra Fichtinger, Sabrina Hösele, Andy Sombke, Leonid Mill, Monika Kustermann, Wolfgang M. Schmidt, Fiona Norwood, Ursula Schlötzer‐Schrehardt, Gerhard Wiche, Rolf Schröder, Lilli Winter   +12 more
doaj   +2 more sources

Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling [PDF]

Cell Death and Disease
Ras family protein plays a key role in transducing signals involved in cytoskeletal remodeling and cell adhesion, which are particularly important in the development of colorectal cancer (CRC).
Jiehui Di, Zhongjun Zhao, Mingyi Xia, Keyu Gao, Keli Chai, Bao Zhu, Wanping Sun, Yanping Zhang, Junnian Zheng, Yong Liu   +9 more
doaj   +2 more sources

Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks [PDF]

Open Biology
Epithelia are multicellular sheets that form barriers defining the internal and external environments. The constant stresses acting at this interface require that epithelial sheets are mechanically robust and provide a selective barrier to the hostile ...
Zuzana Outla, Magdalena Prechova, Katerina Korelova, Jakub Gemperle, Martin Gregor   +4 more
doaj   +2 more sources

Plectin (PLEC)-Related Intermediate Epidermolysis Bullosa Simplex without Extracutaneous Involvement with Response to Dapsone [PDF]

Indian Dermatology Online Journal
Plectinopathies, the spectrum of diseases caused by plectin gene (PLEC) mutations, have a wide range of manifestations, mostly extracutaneous, like pyloric atresia, muscular dystrophy, and cardiomyopathy, along with cutaneous tense blistering ...
Anisha Biswal, Bikash Ranjan Kar, Rahul Mahajan, Liza Mohapatra, Anoop Kumar   +4 more
doaj   +2 more sources