Plectin in Skin Fragility Disorders [PDF]
Cells, 2021 Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.
Dimitra Kiritsi +2 more
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Identifying Plectin Isoform Functions through Animal Models [PDF]
Cells, 2021 Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to intermediate filaments of all types and connects them to junctional complexes, organelles, and inner membrane systems.
Maria J. Castañón, Gerhard Wiche
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Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter [PDF]
Cells, 2021 This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and ...
Gerhard Wiche
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Cells, 2022 In light of recent progress in defining a unifying mechanism for the versatile functions and disease involvement of the cytolinker protein plectin, a series of invited review articles, together with an original research article, were published in Cells ...
Gerhard Wiche
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Plectin in Cancer: From Biomarker to Therapeutic Target [PDF]
Cells, 2021 The cytolinker and scaffolding protein, plectin, has emerged as a potent driver of malignant hallmarks in many human cancers due to its involvement in various cellular activities contributing to tumorigenesis, including cancer cell proliferation ...
Samantha M. Perez +2 more
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Polyarginine Peptide R11–Actin Interaction Induces a Domino Effect on Cytoskeleton Remodeling to Suppress Bladder Cancer Metastasis [PDF]
ResearchCytoskeletal remodeling, particularly actin dynamics, is a central driver of tumor metastasis. However, actin-targeting agents have faced major translational barriers due to poor specificity and the absence of defined druggable sites.
Zhenghong Liu +22 more
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Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration [PDF]
Frontiers in ImmunologyPurposeRegulation of inflammation and re-epithelialization are critical for efficient wound healing. This study explores the role of human α1-antitrypsin (hAAT), an immunomodulatory protein, in modulating inflammation and promoting re-epithelialization ...
Idan Farber +21 more
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Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseases [PDF]
Scientific ReportsArrhythmogenic cardiomyopathy (AC) is a common cause of sudden cardiac arrest and death in young adults. It can be induced by different types of mutations throughout the desmoplakin gene including the R2834H mutation in the extreme carboxyterminus tail ...
Cedric Badowski +3 more
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Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer [PDF]
Cell & BioscienceBackground Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall
Lanning Bai +6 more
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Filamin A in the ovary: a mediator of granulosa cell functions [PDF]
Reproduction and FertilityFilamin A (FLNA) regulates the mechanical properties and shape of cells by cross-linking actin filaments orthogonally. It also serves as a scaffold for numerous interacting proteins, thereby coordinating cell differentiation and morphogenesis.
Yuhao Jiang +9 more
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