Results 21 to 30 of about 3,755 (143)
Plectin in the Central Nervous System and a Putative Role in Brain Astrocytes
Cells, 2021 Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of ...
Maja Potokar, Jernej Jorgačevski
doaj +1 more source
BMC Cancer, 2022 Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation ...
Kana Mizuta +10 more
doaj +1 more source
Vimentin Intermediate Filaments: A Paradigm Shift From Static Structure to Dynamic Cytoplasmic Network [PDF]
BioessaysVimentin intermediate filaments form a dynamic, motile network that interacts with microfilaments and microtubules. We propose a hybrid transport model to explain vimentin filament dynamics through cytoskeletal crosstalk and organelle‐associated transport.
Renganathan B, Adam S, Gelfand V.
europepmc +2 more sources
Plectin-Isoform-Specific Rescue of Hemidesmosomal Defects in Plectin (–/–) Keratinocytes [PDF]
Journal of Investigative Dermatology, 2003 The various plectin isoforms are among the major crosslinking elements of the cytoskeleton. The importance of plectin in epithelia is convincingly supported by the severe skin blistering observed in plectin-deficient humans and mice. Here, we identified plectin 1a (> 500 kDa), a full length plectin variant containing the sequence encoded by the ...
Andrä, Kerstin +7 more
openaire +3 more sources
Cells, 2023 Plectin, a highly versatile cytolinker protein, is crucial for myofiber integrity and function. Accordingly, mutations in the human gene (PLEC) cause several rare diseases, denoted as plectinopathies, with most of them associated with progressive muscle ...
Lilli Winter +11 more
doaj +1 more source
Antibody Characterization Report for Plectin
, 2021 Head to head comparison of available commercial antibodies against Plectin by immunoblot (Western blot), immunoprecipitation and immunofluorescence.
Ayoubi, Riham +5 more
openaire +2 more sources
Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease. [PDF]
Adv Sci (Weinh)Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Prakash A, Iskratsch T.
europepmc +2 more sources
Muscle-Related Plectinopathies
Cells, 2021 Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies.
Michaela M. Zrelski +2 more
doaj +1 more source
[99mTc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging
Pharmaceutics, 2022 Certain receptors are often overexpressed during tumor occurrence and development and closely correlate with carcinogenesis. Owing to its overexpression on the cell membrane and cytoplasm of various tumors, plectin, which is involved in tumor ...
Jiali Gong +4 more
doaj +1 more source
PLoS Genetics, 2011 Autosomal recessive mutations in the cytolinker protein plectin account for the multisystem disorders epidermolysis bullosa simplex (EBS) associated with muscular dystrophy (EBS-MD), pyloric atresia (EBS-PA), and congenital myasthenia (EBS-CMS).
Gernot Walko +12 more
doaj +1 more source