Results 31 to 40 of about 3,755 (143)
Effects of Plectin Depletion on Keratin Network Dynamics and Organization. [PDF]
PLoS ONE, 2016 The keratin intermediate filament cytoskeleton protects epithelial cells against various types of stress and is involved in fundamental cellular processes such as signaling, differentiation and organelle trafficking. These functions rely on the cell type-
Marcin Moch +13 more
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Interaction of Plectin with Keratins 5 and 14: Dependence on Several Plectin Domains and Keratin Quaternary Structure [PDF]
Journal of Investigative Dermatology, 2014 Plectin, a cytolinker of the plakin family, anchors the intermediate filament (IF) network formed by keratins 5 and 14 (K5/K14) to hemidesmosomes, junctional adhesion complexes in basal keratinocytes. Genetic alterations of these proteins cause epidermolysis bullosa simplex (EBS) characterized by disturbed cytoarchitecture and cell fragility.
Bouameur, Jamal-Eddine +5 more
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Biomedicines, 2022 The endothelium plays an important role in the transcytosis of lipoproteins. According to one of the theories, endothelial injury is a triggering factor for the development of atherosclerosis, and intracellular structures, including components of the ...
Anton S. Shakhov, Irina B. Alieva
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Cells, 2021 Cancer-specific plectin (CSP) is a pro-tumorigenic protein selectively expressed on the cell surface of major cancers, including ovarian cancer (OC). Despite its assessable localization, abundance, and functional significance, the therapeutic efficacy of
Samantha M. Perez +3 more
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Plectin-1 Targeted Dual-modality Nanoparticles for Pancreatic Cancer Imaging
EBioMedicine, 2018 Background: Biomarker-targeted molecular imaging holds promise for early detection of pancreatic cancer. The aim of this study was to design and evaluate a plectin-1 targeted multi-functional nanoparticle probe for pancreatic cancer imaging. Methods: 1,2-
Xiao Chen +10 more
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Frontiers in Oncology, 2021 Circulating tumor cells (CTCs) are useful biomarkers of many solid tumors, but are infrequently detected in early stage pancreatic ductal adenocarcinomas (PDACs). The first drainage of pancreatic venous blood flow come to portal vein and pass through the
Byeong Geun Song +15 more
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Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells
Cells, 2020 Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology and pathophysiology. The cytoskeleton (microtubules, intermediate filaments,
Andrey V. Kuznetsov +5 more
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Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. [PDF]
PLoS Medicine, 2008 BackgroundPancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies.
Kimberly A Kelly +8 more
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Brain Circulation, 2016 Objective: In the central nervous system (CNS), β4 integrin is predominantly expressed by endothelial cells lining arterioles. As β4 integrin plays an essential role in epithelial tissues, organizing structural proteins into specialized adhesive ...
Jennifer V Welser-Alves +3 more
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Human Autoantibodies against HD1/Plectin in Paraneoplastic Pemphigus [PDF]
Journal of Investigative Dermatology, 1999 Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with underlying neoplasms. PNP patients develop characteristic autoantibodies directed against multiple antigens, mostly identified as members of the plakin family of cytoplasmic proteins (desmoplakin I and II, bullous pemphigoid antigen I, envoplakin, and ...
Proby, Charlotte +4 more
openaire +2 more sources