Results 51 to 60 of about 3,755 (143)

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source

Glu20Ter Variant in PLEC 1f Isoform Causes Limb-Girdle Muscle Dystrophy with Lung Injury

Frontiers in Neurology, 2017
Plectinopathies are orphan diseases caused by PLEC gene mutations. PLEC is encoding the protein plectin, playing a role in linking cytoskeleton components in various tissues.
Roman V. Deev, Roman V. Deev, Sergei N. Bardakov, Mikhail O. Mavlikeev, Ivan A. Yakovlev, Ivan A. Yakovlev, Ivan A. Yakovlev, Zoya R. Umakhanova, Patimat G. Akhmedova, Raisat M. Magomedova, Irina A. Chekmaryeva, Gimat D. Dalgatov, Artur A. Isaev   +12 more
doaj   +1 more source

Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases

MedComm, Volume 7, Issue 3, March 2026.
This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Shan Cao, Tianyu Wang, Chen Lv, Shanshan Ma, Gongqi Yu, Qianqian Xia, Tingting Liu, Yueqian Yu, Lele Sun, Xiaoyan Pei, Qing Zhao, Zhenzhen Wang, Chuan Wang, Yongxia Liu, Shengli Chen, Jianwen Wang, Guizhi Zhou, Hong Liu, Yonghu Sun, Furen Zhang   +19 more
wiley   +1 more source

Bioelectronic Technology for Nutritional Research—a Novel In Vitro Platform for a Better Understanding of Human Gut Barrier Absorption

Advanced Biology, Volume 10, Issue 2, February 2026.
This is the first study to demonstrate that the e‐transmembrane gut model provides more accurate physiological predictions than conventional cell culture inserts when tested by the dietary compound butyrate. The bioelectronic e‐transmembrane platform integrates technological and biological optimizations, enabling the hosting of a complex human gut in ...
Verena Stoeger, Magdalena Strauss, Kumar Thurimella, Shani Elias‐Kirma, Izabella Niewczas, Etkin Parlar, Erika Schaudy, Chrysanthi‐Maria Moysidou, Stephen Voong, Jory Lietard, Jonathan Clark, Christopher Gerner, Róisín M. Owens   +12 more
wiley   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Population Genomics Provides Novel Insights Into Evolutionary Relationships and Local Adaptation of Two Ecotypes Coilia nasus

Ecology and Evolution, Volume 15, Issue 12, December 2025.
Based on whole‐genome resequencing, we determined that the freshwater‐resident form (C. nasus taihuensis) is an ecotype of anadromous Coilia nasus, not a distinct subspecies. The two ecotypes diverged approximately 4.6 thousand years ago, coinciding with the formation of Tai Lake.
Fengjiao Ma, Sheng Wang, Wenzhi Ma, Hui Wang, Haotian Jin, Legen Peng, Guojun Yin, Kai Liu   +7 more
wiley   +1 more source

Expanding the Clinical Phenotype of PLECTIN-Related Plectinopathies. [PDF]

Iran J Public Health
Background: Plectinopathy-associated disorders are caused by mutations in the PLECTIN (PLEC) gene encoding Plectin protein. PLEC mutations cause a spectrum of diseases defined by varying degrees of signs, mostly with epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) and plectinopathy-related disorder is limb-girdle muscular dystrophy type ...
Torbati PN, Doosti M, Sarraf P, Boostani R, Ahangari N, Toosi MB, Tafakhori A, Babaei M, Abedini S, Malek H, Maskani S, Safi M, Karimiani EG.   +12 more
europepmc   +3 more sources

Plectin contributes to mechanical properties of living cells

American Journal of Physiology-Cell Physiology, 2009
Plectin is a 500-kDa cross-linking protein that plays important roles in a number of cell functions including migration and wound healing. We set out to characterize the role of plectin in mechanical properties of living cells. Plectin−/− cells were less stiff than plectin+/+ cells, but the slopes of the two power laws in response to loading ...
Na, Sungsoo, Chowdhury, Farhan, Tay, Bernard, Ouyang, Mingxing, Gregor, Martin, Wang, Yingxiao, Wiche, Gerhard, Wang, Ning   +7 more
openaire   +4 more sources

R405W Desmin Knock‐In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle. Methods A comprehensive characterization of the skeletal muscle pathology in hetero‐ and homozygous R405W desmin
Sabrina Batonnet‐Pichon, Florence Delort, Alain Lilienbaum, Carolin Berwanger, Dorothea Schultheis, Ursula Schlötzer‐Schrehardt, Andreas Schmidt, Steffen Uebe, Yosra Baiche, Tom J. Eisenack, Débora Broch Trentini, Markus Mallek, Leonid Mill, Ana Ferreiro, Bettina Eberhard, Thomas Lücke, Markus Krüger, Christian Thiel, Rolf Schröder, Christoph S. Clemen   +19 more
wiley   +1 more source

Plectin-1 as a Novel Biomarker for Pancreatic Cancer [PDF]

Clinical Cancer Research, 2011
Abstract Purpose: We are in great need of specific biomarkers to detect pancreatic ductal adenocarcinoma (PDAC) at an early stage, ideally before invasion. Plectin-1 (Plec1) was recently identified as one such biomarker. However, its suitability as a specific biomarker for human pancreatic cancer, and its usability as an imaging ...
Bausch, Dirk, Thomas, Stephanie, Mino-Kenudson, Mari, Fernandez-del-Castillo, Carlos, Bauer, T. W., Williams, M., Warshaw, Andrew Louis, Thayer, Sarah P., Kelly, Kimberly A.   +8 more
openaire   +3 more sources