Results 61 to 70 of about 3,755 (143)

Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 12, Page 1555-1564, December 2025.
Summary Background and Objectives Pemphigoid diseases are primarily mediated by IgG or IgA autoantibodies against the cutaneous basement membrane zone (BMZ). Although recent observations suggest the existence of exclusively IgM‐mediated pemphigoid disease, a larger study is lacking.
Kaan Yilmaz, Stephanie Goletz, Christoph M. Hammers, Katharina Boch, Claudia Zeidler, Henning Wiegmann, Estelle Bergmann, Tina Rastegar Lari, Onur Dikmen, Nina Häring, Robert Strohal, Andreas Kleinheinz, Eva N. Hadaschik, Nina van Beek, Sonja Ständer, Enno Schmidt   +15 more
wiley   +1 more source

Dynamic alteration of poroelastic attributes as determinant membrane nanorheology for endocytosis of organ specific targeted gold nanoparticles

Journal of Nanobiotechnology, 2022
Background Efficacy of targeted drug delivery using nanoparticles relies on several factors including the uptake mechanisms such as phagocytosis, macropinocytosis, micropinocytosis and receptor mediated endocytosis.
Tanmay Kulkarni, Debabrata Mukhopadhyay, Santanu Bhattacharya   +2 more
doaj   +1 more source

Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding [PDF]

The Journal of Cell Biology, 1999
Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a link between the intermediate filament network and the extracellular matrix. We have investigated the recruitment of plectin into hemidesmosomes by the α6β4 integrin and have shown that the cytoplasmic domain of the β4 subunit associates with an NH2-terminal fragment ...
Geerts, Dirk, Fontao, Lionel, Nievers, Mirjam G., Schaapveld, Roel Q., Purkis, Patricia E., Wheeler, Grant N, Lane, E. Birgitte, Leigh, Irene M., Sonnenberg, Arnoud   +8 more
openaire   +4 more sources

Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
After consecutive 5‐day periods of energy balance and energy deficit (ED, 78% reduced energy availability—EA) including aerobic exercise, trained males experienced reduced fat and fat‐free mass, alongside hormonal and metabolic adaptations favoring energy preservation and greater fat oxidation at rest and during exercise, without changes in resting ...
Yusuke Nishimura, Carl Langan‐Evans, Harry L. Taylor, Wee L. Foo, James P. Morton, Sam Shepherd, Juliette A. Strauss, Jatin G. Burniston, José L. Areta   +8 more
wiley   +1 more source

No major role for rare plectin variants in arrhythmogenic right ventricular cardiomyopathy.

PLoS ONE, 2018
AimsLikely pathogenic/pathogenic variants in genes encoding desmosomal proteins play an important role in the pathophysiology of arrhythmogenic right ventricular cardiomyopathy (ARVC).
Edgar T Hoorntje, Anna Posafalvi, Petros Syrris, K Joeri van der Velde, Marieke C Bolling, Alexandros Protonotarios, Ludolf G Boven, Nuria Amat-Codina, Judith A Groeneweg, Arthur A Wilde, Nara Sobreira, Hugh Calkins, Richard N W Hauer, Marcel F Jonkman, William J McKenna, Perry M Elliott, Richard J Sinke, Maarten P van den Berg, Stephen P Chelko, Cynthia A James, J Peter van Tintelen, Daniel P Judge, Jan D H Jongbloed   +22 more
doaj   +1 more source

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

Cell Reports, 2015
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive.
Yaming Jiu, Jaakko Lehtimäki, Sari Tojkander, Fang Cheng, Harri Jäälinoja, Xiaonan Liu, Markku Varjosalo, John E. Eriksson, Pekka Lappalainen   +8 more
doaj   +1 more source

Targeted Inactivation of a Developmentally Regulated Neural Plectin Isoform (Plectin 1c) in Mice Leads to Reduced Motor Nerve Conduction Velocity [PDF]

Journal of Biological Chemistry, 2009
Cytolinker proteins stabilize cells mechanically, regulate cytoskeleton dynamics, and provide scaffolds for signaling molecules. For plectin, the prototype of these proteins, an unusual diversity of isoforms has been reported, which show distinct expression patterns, subcellular localizations, and functions.
Fuchs, Peter, Zoerer, Michael, Reipert, Siegfried, Rezniczek, Günther, Propst, Friedrich, Walko, Gernot, Fischer, Irmgard, Bauer, Jan, Leschnik, Michael W., Lüscher, Bernhard, Thalhammer, Johann, Lassmann, Hans, Wiche, Gerhard   +12 more
openaire   +3 more sources

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Regeneration reaches a hidden limit under mechanical stretch. Prolonged tension alters dermal–epidermal communication, exhausting epidermal stem cells via MMP2–COL17A1 signaling. MMP2 inhibition by Marimastat preserves adhesion and regenerative capacity, offering a potential strategy to overcome the inherent boundaries of skin expansion.
Yidan Sun, Qili Qian, Luwen Xu, Bowen Gao, Ting Li, Yin Li, Jiayi Zheng, Qiaoyu Fu, Xi Cheng, Nuo Chen, Sijia Wang, Liang Zhang, Caiyue Liu, Qingfeng Li   +13 more
wiley   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, Volume 5, Issue 11, November 2025.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source

Autophagy‐Targeting Nanomedicine: Strike at the Heart of the Cancer via Precise Modulation of Autophagy

Exploration, Volume 5, Issue 5, October 2025.
This review emphasizes the critical role of autophagy in cancer treatment, highlighting the development of autophagy‐targeting nanomedicines and their applications in combination therapies. It explores how nanoplatforms can effectively regulate autophagy, underscoring the potential of integrating autophagy modulation with other treatment strategies to ...
Zhouyi Sun, Huali Zuo, Kai Zhang, Yang Liu, Qianwen Wang, Qitao Hu, Jiwei Qian, Andreas Lundqvist, Bo Zhang, Weiyu Chen, Zhe Tang   +10 more
wiley   +1 more source