Results 111 to 120 of about 5,990 (210)
The systemic angiogenic response during bone healing [PDF]
, 2018 Introduction: Angiogenesis is known to be a critical and closely regulated step during bone formation and fracture healing driven by a complex interaction of various cytokines.
Henle, Philipp +4 more
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The Roles of EDA2R in Ageing and Disease
Aging Cell, Volume 24, Issue 12, December 2025.Elevated expression of the ectodysplasin A2 receptor (EDA2R) has been linked to ageing and disease. We appraise the roles of EDA2R in these processes, exploring mechanisms of action, biomarker potential and therapeutic relevance of EDA2R in multiple contexts. ABSTRACT Ageing is a complex biological process driven, in part, by inflammaging.
Gemma Farrington +9 more
wiley +1 more source
Pleiotrophin Exerts Its Migration and Invasion Effect through the Neuropilin-1 Pathway
Neoplasia: An International Journal for Oncology Research, 2015 Pleiotrophin (PTN) is a pleiotropic growth factor that exhibits angiogenic properties and is involved in tumor growth and metastasis. Although it has been shown that PTN is expressed in tumor cells, few studies have investigated its receptors and their ...
Rania Elahouel +8 more
doaj +1 more source
Retinal stem cells: promising candidates for retina transplantation [PDF]
, 2018 Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor degeneration, one of the major causes of blindness.
Arsenijevic, Yvan, Djojosubroto, Meta
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Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs [PDF]
, 2016 fusion between the EML4 (echinoderm microtubule-associated protein-like) and ALK (anaplastic lymphoma kinase) genes was identified in non-small cell lung cancer (NSCLC) in 2007 and there has been rapid progress in applying this knowledge to the benefit ...
Bayliss, R +4 more
core +2 more sources
Pleiotrophin antagonizes Brd2 during neuronal differentiation.
Journal of cell science, 2014 Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression. Brd2 is expressed in proliferating neuronal progenitors, displays cell-cycle-stimulating activity and, when overexpressed, impairs neuronal differentiation.
García-Gutiérrez, Pablo +3 more
openaire +2 more sources
Cellular interactions in the tumor microenvironment: the role of secretome [PDF]
, 2019 Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro +6 more
core +1 more source
European Journal of Pharmacology, 2010 Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury. Upregulation of PTN levels in injured dorsal root ganglion correlates with decreased mechanical allodynia and faster recovery from Chronic Constriction Injury of the rat sciatic nerve.
Gramage, Esther +1 more
openaire +3 more sources
Cell Reports, 2012 The mechanisms through which the bone marrow (BM) microenvironment regulates hematopoietic stem cell (HSC) fate remain incompletely understood. We examined the role of the heparin-binding growth factor pleiotrophin (PTN) in regulating HSC function in the
Heather A. Himburg +14 more
doaj +1 more source
9-cis-retinoic acid during in vitro maturation improves development of the bovine oocyte and increases midkine but not IGF-I expression in cumulus-granulosa cells [PDF]
, 2012 The isomer 9-cis of retinoic acid (9-cis-RA) exerts a beneficial effect on bovine in vitro development when added to in vitro maturation (IVM) culture. In the present work, 9-cis-RA 5 nM was found to be stimulatory as opposed to 500 nM (toxic).
Carneiro, Gustavo +9 more
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