Results 161 to 170 of about 6,090 (193)

Midkine and pleiotrophin in neural development and cancer

Cancer Letters, 2004
The midkine (MK) family consists of only two members, namely heparin-binding growth factors MK and pleiotrophin (PTN). During embryogenesis, MK is highly expressed in the mid-gestational period, whereas PTN expression reaches the maximum level around birth.
Kenji, Kadomatsu, Takashi, Muramatsu
exaly   +3 more sources

Pleiotrophin prevents cocaine-induced toxicity in vitro

European Journal of Pharmacology, 2008
Pleiotrophin is a cytokine involved in differentiation, survival and repair processes in the central nervous system. Pleiotrophin is upregulated in the brain after administration of different drugs of abuse, thus suggesting a protective role of this cytokine on drug-induced toxicity.
Esther, Gramage, Luis F, Alguacil, Gonzalo, Herradon   +2 more
openaire   +2 more sources

Roles of pleiotrophin in tumor growth and angiogenesis

European Cytokine Network, 2009
Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis. Although interest in the involvement of PTN in tumor growth is increasing, many questions remain unanswered, particularly concerning the receptors and the signaling
Evangelia, Papadimitriou, Constantinos, Mikelis, Evgenia, Lampropoulou, Marina, Koutsioumpa, Katerina, Theochari, Sotiria, Tsirmoula, Christina, Theodoropoulou, Margarita, Lamprou, Evanthia, Sfaelou, Dionyssios, Vourtsis, Panagiotis, Boudouris   +10 more
openaire   +2 more sources

Elevated expression of pleiotrophin in human hypertrophic scars

Journal of Molecular Histology, 2012
Hypertrophic scar (HS) is a cutaneous fibrotic disorder characterized by persistent inflammation, excessive proliferation of fibroblasts, and abundant accumulation of extracellular matrix (ECM) proteins. Pleiotrophin (PTN) is a highly conserved and secreted ECM-associated protein that belongs to a novel family of heparin-binding cytokines with multiple
Qian, Zhang, Kai, Tao, Wei, Huang, Yaguang, Tian, Xiaoyan, Liu   +4 more
openaire   +2 more sources

The neurotrophic factor pleiotrophin modulates amphetamine‐seeking behaviour and amphetamine‐induced neurotoxic effects: evidence from pleiotrophin knockout mice

Addiction Biology, 2010
ABSTRACTPleiotrophin (PTN), a neurotrophic factor with important roles in survival and differentiation of dopaminergic neurons, is up‐regulated in the nucleus accumbens after amphetamine administration suggesting that PTN could modulate amphetamine‐induced pharmacological or neuroadaptative effects.
Esther, Gramage, Alessia, Putelli, Maria J, Polanco, Carmen, González-Martín, Laura, Ezquerra, Luis F, Alguacil, Pablo, Pérez-Pinera, Thomas F, Deuel, Gonzalo, Herradón   +8 more
openaire   +2 more sources

New connections: Pleiotrophin and glioma

Science Signaling, 2017
The cytokine pleiotrophin promotes the invasion and vascularization of glioma.
openaire   +1 more source

Pleiotrophin induces formation of functional neovasculature in vivo

Biochemical and Biophysical Research Communications, 2005
Pleiotrophin (PTN) is a heparin-binding growth/differentiation inducing cytokine that shares 50% amino acid sequence identity and striking domain homology with Midkine (MK), the only other member of the Ptn/Mk developmental gene family. The Ptn gene is expressed in sites of early vascular development in embryos and in healing wounds and its ...
Karen L, Christman, Qizhi, Fang, Anne J, Kim, Richard E, Sievers, Hubert H, Fok, Albert F, Candia, Kenneth J, Colley, Gonzalo, Herradon, Laura, Ezquerra, Thomas F, Deuel, Randall J, Lee   +10 more
openaire   +2 more sources

Pleiotrophin promotes capillary-like sprouting from senescent aortic rings

Cytokine, 2013
Pleiotrophin (PTN) is a heparin-binding growth factor involved in angiogenesis during development and tumor growth. Plasmid therapy with PTN also induces angiogenesis after myocardial infarction. During aging, angiogenesis is impaired and we therefore examined whether a growth factor therapy with PTN is able to restore neovascularization.We evaluated ...
Besse, Sophie, Comte, Romain, Fréchault, Sophie, Courty, José, de Leiris, Joël, Delbé, Jean   +5 more
openaire   +3 more sources

The role of midkine and pleiotrophin in liver regeneration

Liver International, 2004
Abstract: Background/Purpose: We studied roles of two closely related heparin‐binding growth factors, midkine (MK) and plieotrophin (PTN) in the processes of liver regeneration after partial hepatectomy.Methods: Liver regeneration was comparatively analyzed using mice deficient in the MK gene (Mdk), mice deficient in the pleiotrophin gene (Ptn) and ...
Keiko, Ochiai, Hisako, Muramatsu, Satoshi, Yamamoto, Hisami, Ando, Takashi, Muramatsu   +4 more
openaire   +2 more sources

Pleiotrophin is expressed in avian somites and tendon anlagen

Histochemistry and Cell Biology, 2009
Pleiotrophin (Ptn) is a secreted, developmentally regulated growth factor associated with the extracellular matrix. During mammalian embryogenesis, Ptn has been suggested to play a role in the development of various embryonic structures including nervous system and skeleton.
Mittapalli, Venugopal Rao, Christ, Bodo, Pröls, Felicitas, Scaal, Martin   +3 more
openaire   +3 more sources