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Localization of pleiotrophin and midkine in the postnatal developing cerebellum
Neuroscience Letters, 1994We demonstrated that pleiotrophin (PTN) and midkine (MK), proteins which constitute a novel heparin-binding growth factor family, are expressed in the postnatal developing cerebellar cortex by an immunohistochemical method. The expression patterns of both factors were quite similar both temporally and spatially; the levels of protein expression reached
K, Matsumoto +7 more
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Elevated expression of pleiotrophin in human hypertrophic scars
Journal of Molecular Histology, 2012Hypertrophic scar (HS) is a cutaneous fibrotic disorder characterized by persistent inflammation, excessive proliferation of fibroblasts, and abundant accumulation of extracellular matrix (ECM) proteins. Pleiotrophin (PTN) is a highly conserved and secreted ECM-associated protein that belongs to a novel family of heparin-binding cytokines with multiple
Qian, Zhang +4 more
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An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis.
Cancer research, 1997Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in tumorigenesis, they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo.
CHOUDHURI, R. +4 more
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Pleiotrophin attenuates the senescence of dental pulp stem cells
Oral Diseases, 2023Lili Zhang, Dengsheng Xia, Luyuan Jin
exaly
Pleiotrophin: A Cytokine with Diverse Functions and a Novel Signaling Pathway
Archives of Biochemistry and Biophysics, 2002Thomas F Deuel, Zhao-Yi Wang
exaly