Results 171 to 180 of about 3,583 (200)

The new growth factor pleiotrophin (HB-GAM) mRNA is selectively present in the meningothelial cells of human meningiomas

Neuroscience Letters, 1992
The distribution of the messenger RNA coding for the recently cloned growth factor pleiotrophin (HB-GAM) was studied in human benign meningiomas using in situ hybridization histochemistry and oligonucleotide probes.
Pierre Mailleux, P Mailleux
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Pleiotrophin: Analysis of the endothelialisation potential

Advances in Medical Sciences, 2019
Endothelialisation of vascular substitutes, in fact, remains one of the most unsolved problems in cardiovascular diseases treatment. Stromal Derived Factor 1 (SDF-1) has been largely investigated as an endothelialisation promoter and Pleiotrophin is a promising alternative. Although it has been known to exert beneficial effects on different cell types,
Copes F., Ramella M., Fusaro L., Mantovani D., Cannas M., Boccafoschi F.   +5 more
openaire   +3 more sources

Pleiotrophin is downregulated in human keloids

Archives of Dermatological Research, 2016
Keloid is an abnormal hyperproliferative scarring process with involvement of complex genetic and triggering environmental factors. Previously published dysregulated gene expression profile of keloids includes genes involved in tumor formation. Pleiotrophin (PTN) is a secreted, heparin-binding growth factor which is involved in various biological ...
Dong Hun, Lee, Cheng Long, Jin, Yeji, Kim, Mi Hee, Shin, Ji Eun, Kim, Minji, Kim, Min Jung, Lee, Soyun, Cho   +7 more
openaire   +2 more sources

Pleiotrophin inhibits hippocampal long-term potentiation: A role of pleiotrophin in learning and memory

Growth Factors, 2009
Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal synaptic plasticity and learning. To further understand the involvement of PTN in memory processes, we performed in vitro electrophysiological studies in PTN-stimulated CA1 from rat hippocampal slices combined with the behavioural testing of PTN deficient (PTN - / -
Nuria, del Olmo, Esther, Gramage, Luis F, Alguacil, Pablo, Pérez-Pinera, Thomas F, Deuel, Gonzalo, Herradón   +5 more
openaire   +2 more sources

The role of midkine and pleiotrophin in liver regeneration

Liver International, 2004
Abstract: Background/Purpose: We studied roles of two closely related heparin‐binding growth factors, midkine (MK) and plieotrophin (PTN) in the processes of liver regeneration after partial hepatectomy.Methods: Liver regeneration was comparatively analyzed using mice deficient in the MK gene (Mdk), mice deficient in the pleiotrophin gene (Ptn) and ...
Keiko, Ochiai, Hisako, Muramatsu, Satoshi, Yamamoto, Hisami, Ando, Takashi, Muramatsu   +4 more
openaire   +2 more sources

Roles of pleiotrophin in tumor growth and angiogenesis

European Cytokine Network, 2009
Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis. Although interest in the involvement of PTN in tumor growth is increasing, many questions remain unanswered, particularly concerning the receptors and the signaling
Evangelia, Papadimitriou, Constantinos, Mikelis, Evgenia, Lampropoulou, Marina, Koutsioumpa, Katerina, Theochari, Sotiria, Tsirmoula, Christina, Theodoropoulou, Margarita, Lamprou, Evanthia, Sfaelou, Dionyssios, Vourtsis, Panagiotis, Boudouris   +10 more
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Pleiotrophin prevents cocaine-induced toxicity in vitro

European Journal of Pharmacology, 2008
Pleiotrophin is a cytokine involved in differentiation, survival and repair processes in the central nervous system. Pleiotrophin is upregulated in the brain after administration of different drugs of abuse, thus suggesting a protective role of this cytokine on drug-induced toxicity.
Esther Gramage, Luis F Alguacil, Gonzalo Herradón   +2 more
exaly   +3 more sources

Pleiotrophin and related molecules

1997
Abstract A number of polypeptide growth factors have marked affinity for the glycosaminoglycan heparin and for heparan sulphates found on cell surfaces and in the extracellular matrix (ECM). These growth factors are collectively called heparin-binding growth factors (HBGFs) and comprise distinct polypeptides such as the vascular ...
Anke M Schulte, Anton Wellstein
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Pleiotrophin as a potential biomarker in breast cancer patients

Clinica Chimica Acta, 2017
Pleiotrophin (PTN), a multifunctional growth factor, is up-regulated in many tumors. PTN is reported to play an important role in the regulation of several cellular processes. The objective of this study is to evaluate the clinical significance of PTN as a tumor marker in breast cancer (BC).Serum PTN levels were detected in 105 BC patients and 40 ...
Jiequn, Ma, Ying, Kong, Haocheng, Nan, Shengyang, Qu, Xiao, Fu, Lili, Jiang, Wenjuan, Wang, Hui, Guo, Shounian, Zhao, Jianjun, He, Kejun, Nan   +10 more
openaire   +2 more sources

Pleiotrophin is expressed in avian somites and tendon anlagen

Histochemistry and Cell Biology, 2009
Pleiotrophin (Ptn) is a secreted, developmentally regulated growth factor associated with the extracellular matrix. During mammalian embryogenesis, Ptn has been suggested to play a role in the development of various embryonic structures including nervous system and skeleton.
Mittapalli, Venugopal Rao, Christ, Bodo, Pröls, Felicitas, Scaal, Martin   +3 more
openaire   +3 more sources