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Pleiotrophin promotes perineural invasion in pancreatic cancer
World Journal of Gastroenterology, 2013 Perineural invasion (PNI) in pancreatic cancer is an important cause of local recurrence, but little is known about its mechanism. Pleiotrophin (PTN) is an important neurotrophic factor. It is of interest that our recent experimental data showed its involvement in PNI of pancreatic cancer.
Jun, Yao +3 more
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Pleiotrophin: Analysis of the endothelialisation potential
Advances in Medical Sciences, 2019Endothelialisation of vascular substitutes, in fact, remains one of the most unsolved problems in cardiovascular diseases treatment. Stromal Derived Factor 1 (SDF-1) has been largely investigated as an endothelialisation promoter and Pleiotrophin is a promising alternative. Although it has been known to exert beneficial effects on different cell types,
Copes F. +5 more
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Pleiotrophin prevents cocaine-induced toxicity in vitro
European Journal of Pharmacology, 2008Pleiotrophin is a cytokine involved in differentiation, survival and repair processes in the central nervous system. Pleiotrophin is upregulated in the brain after administration of different drugs of abuse, thus suggesting a protective role of this cytokine on drug-induced toxicity.
Esther Gramage +2 more
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Pleiotrophin is downregulated in human keloids
Archives of Dermatological Research, 2016Keloid is an abnormal hyperproliferative scarring process with involvement of complex genetic and triggering environmental factors. Previously published dysregulated gene expression profile of keloids includes genes involved in tumor formation. Pleiotrophin (PTN) is a secreted, heparin-binding growth factor which is involved in various biological ...
Dong Hun, Lee +7 more
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The effects of pleiotrophin in proliferative vitreoretinopathy
Graefe's Archive for Clinical and Experimental Ophthalmology, 2017The purpose of our study was to investigate the effects of pleiotrophin (PTN) in proliferative vitreoretinopathy (PVR) both in vitro and in vivo.Immunofluorescence was used to observe the PTN expression in periretinal membrane samples from patients with PVR and controls. ARPE-19 cells were exposed to TGF-β1.
Xue, Ding +7 more
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Growth Factors, 2009
Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal synaptic plasticity and learning. To further understand the involvement of PTN in memory processes, we performed in vitro electrophysiological studies in PTN-stimulated CA1 from rat hippocampal slices combined with the behavioural testing of PTN deficient (PTN - / -
Nuria, del Olmo +5 more
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Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal synaptic plasticity and learning. To further understand the involvement of PTN in memory processes, we performed in vitro electrophysiological studies in PTN-stimulated CA1 from rat hippocampal slices combined with the behavioural testing of PTN deficient (PTN - / -
Nuria, del Olmo +5 more
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The role of pleiotrophin in bone repair
Injury, 2014Bone has an enormous capacity for growth, regeneration, and remodelling, largely due to induction of osteoblasts that are recruited to the site of bone formation. Although the pathways involved have not been fully elucidated, it is well accepted that the immediate environment of the cells is likely to play a role via cell–matrix interactions, mediated ...
Margarita, Lamprou +4 more
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Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice
Journal of Molecular Neuroscience, 2021Postoperative cognitive dysfunction (POCD) is a major postoperative neurological complication in children and the elderly. However, the detailed mechanisms underlying this process remain unclear. This study aims to investigate the effect of pleiotrophin on sevoflurane-induced neuroinflammation and cognitive impairment. The novel object recognition test
Shunhong Mao +3 more
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Pleiotrophin and related molecules
1997Abstract A number of polypeptide growth factors have marked affinity for the glycosaminoglycan heparin and for heparan sulphates found on cell surfaces and in the extracellular matrix (ECM). These growth factors are collectively called heparin-binding growth factors (HBGFs) and comprise distinct polypeptides such as the vascular ...
Anke M Schulte, Anton Wellstein
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Midkine and pleiotrophin in neural development and cancer
Cancer Letters, 2004The midkine (MK) family consists of only two members, namely heparin-binding growth factors MK and pleiotrophin (PTN). During embryogenesis, MK is highly expressed in the mid-gestational period, whereas PTN expression reaches the maximum level around birth.
Kenji, Kadomatsu, Takashi, Muramatsu
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