Results 161 to 170 of about 4,153 (193)

Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression. [PDF]

Nat Commun
Vukušić K, Tolić IM.
europepmc   +1 more source

KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer. [PDF]

Cell Death Discov
Zhou K, He Y, Lin X, Zhou H, Xu X, Xu J.
europepmc   +1 more source

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization. [PDF]

Nat Commun
Belal H, Ng EFY, Ohta M, Meitinger F.
europepmc   +1 more source

Author Correction: Drosophila Alms1 proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop. [PDF]

EMBO J
Brunet M, Thomas J, Lapart JA, Krüttli L, Laporte MH, Riparbelli MG, Callaini G, Durand B, Morel V.   +8 more
europepmc   +1 more source

The mitotic stopwatch limits the proliferation of whole genome doubled cells

Allan L, Foy R, Keli M, Saurin A.
europepmc   +1 more source

In vitro approaches to study centriole and cilium function in early mouse embryogenesis

Voelkl I, Civetta T, Egg M, Huber M, Feng S, Dammermann A, Buecker C.   +6 more
europepmc   +1 more source

TEC kinase stabilizes PLK4 to promote liver cancer metastasis

Cancer Letters, 2022
Aberrated PLK4 expression has been reported in different malignancies and causes centrosome amplification, aneuploidy, and genomic instability. However, the mechanism by which PLK4 is regulated in carcinogenesis remains not fully characterised.
Wing-Lim Chan, Yick-Pang Ching
exaly   +2 more sources

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PLK4: a promising target for cancer therapy

Journal of Cancer Research and Clinical Oncology, 2019
Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates centriole duplication. PLK4 deregulation causes centrosome number abnormalities, mitotic defects, chromosomal instability and, consequently, tumorigenesis. Therefore, PLK4 has emerged as a therapeutic target for the treatment of multiple cancers.
Yi Zhao, Xin Wang
exaly   +3 more sources

Structural and Functional Analyses of the FAM46C/Plk4 Complex

Structure, 2020
FAM46C, a non-canonical poly(A) polymerase, is frequently mutated in multiple myeloma. Loss of function of FAM46C promotes cell survival of multiple myeloma, suggesting a tumor-suppressive role. FAM46C is also essential for fastening sperm head and flagellum, indispensable for male fertility. The molecular mechanisms of these functions of FAM46C remain
Guijun Shang, Guoming Gao, Xuewu Zhang   +2 more
exaly   +3 more sources

Cell fate in the Hand of Plk4

Nature Cell Biology, 2007
The transcription factor Hand1 is required for cell-fate determination during placental development. Recent work shows that release of Hand1 from the nucleolus controls differentiation of trophoblast stem cells into trophoblast giant cells, and this switch is controlled by the antagonistic activities of HICp40 and Polo-like kinase-4 (Plk4).
Marvin E. Tanenbaum, René H. Medemao
openaire   +1 more source