Results 171 to 180 of about 4,153 (193)

A non‐canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM 1 phosphorylation [PDF]

EMBO Reports, 2016
Centrioles are the major constituents of the animal centrosome, in which Plk4 kinase serves as a master regulator of the duplication cycle. Many eukaryotes also contain numerous peripheral particles known as centriolar satellites.
Karin Barnouin, Ambrosius P Snijders, Takashi Toda   +2 more
exaly   +2 more sources

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PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma

Cancer Letters, 2019
Despite the clinical success of temozolomide (TMZ), its sensitivity remains a major challenge in glioblastoma (GBM). Here, we show that PLK4 affects TMZ sensitivity by regulating the IKBKE/NF-κB axis. The mRNA level of PLK4 was significantly associated with glioma grade progression and inversely correlated with overall survival (OS) in patients with ...
Zengguang Wang, Anling Zhang, Yingwei Zhen   +2 more
exaly   +3 more sources

Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis

Nature Genetics, 2005
The polo-like kinase Plk4 (also called Sak) is required for late mitotic progression, cell survival and postgastrulation embryonic development. Here we identified a phenotype resulting from Plk4 haploinsufficiency in Plk4 heterozygous cells and mice. Plk4+/- embryonic fibroblasts had increased centrosomal amplification, multipolar spindle formation and
Michael A, Ko, Carla O, Rosario, John W, Hudson, Sarang, Kulkarni, Aaron, Pollett, James W, Dennis, Carol J, Swallow   +6 more
openaire   +2 more sources

PLK4: a link between centriole biogenesis and cancer

Expert Opinion on Therapeutic Targets, 2017
Polo like kinase (PLK) is known to play a pivotal role in various cell cycle processes to perpetuate proper division and growth of the cells. Polo like kinase-4 (PLK4) is one such kinase that appears in low abundance and plays a well-characterized role in centriole duplication. PLK4 deregulation (i.e.
Radhika Radha, Maniswami, Seema, Prashanth, Archana Venkataramana, Karanth, Sindhu, Koushik, Hemalatha, Govindaraj, Ramesh, Mullangi, Sriram, Rajagopal, Sooriya Kumar, Jegatheesan   +7 more
openaire   +2 more sources

Role of PLK4 inhibition in cancer therapy

Cancer and Metastasis Reviews
Genomic instability is a hallmark of cancer and is associated with tumor progression and therapeutic resistance. Centrioles and centrosomes are a critical determinant of genomic stability. Polo-like kinase 4 (PLK4) is a serine-threonine kinase that plays a critical role in the regulation of centrosome duplication.
Kishore, Banik, Thomas J, Hayman
exaly   +3 more sources

Mechanisms of Plk4 haploinsufficiency in hepatocellular carcinogenesis

Journal of Clinical Oncology, 2009
11100 Background: The pathogenesis of hepatocellular carcinoma (HCC) is multifactorial and includes genetic predisposition, though the precise nature of the latter is as yet poorly understood. Mice heterozygous for the polo like kinase Plk4 develop spontaneous HCC and human HCC cases show a high rate of LOH (loss of heterozygosity) at the Plk4 locus.
P. Wu, C. Rosario, J. Paderova, R. Gladdy, M. Ko, J. Squire, J. Dennis, C. Swallow   +7 more
openaire   +1 more source

Plk4 Regulates Centriole Duplication in the Embryonic Development of Zebrafish

Developmental Biology
PLK4 plays a crucial role in centriole duplication, which is essential for maintaining cellular processes such as cell division, cytoskeletal stability, and cilia formation. However, the mechanisms of PLK4 remain incompletely understood, especially in the embryonic development of vertebrate species.
Zhiyu, Mu, Pengfei, Zheng, Shuangyu, Liu, Yunsi, Kang, Haibo, Xie   +4 more
openaire   +2 more sources

Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4

Journal of Medicinal Chemistry
Polo-like kinase 4 (PLK4) is a therapeutic target of high interest due to its essential role in mitotic regulation and centriole duplication. Recently, centriole depletion driven by PLK4 inhibition has been identified as a synthetically lethal target for cancers with elevated TRIM37 expression.
Joon Won Jeong, Trevor Chang, Jeremy M. Murray, Ryan L. Gonciarz, Justin M. Salvant, Andre H. St. Amant, Sanjay Bhattarai, Jae H. Chang, Jo-Ting Chang, Dana M. Gwinn, Christopher Kochansky, Rhea Matsuura, Leo Mok, Nina M. Muñoz, Andrew G. Raub, David Shaya, Ziqiang Wang, Wei Xu, Kai S. Yang, Heather J. Finlay, Brian A. Sherer   +20 more
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Investigating the role of Plk4 in vivo

Explorer le rôle de Plk4 in vivo Les centrosomes sont les principaux centres organisateurs des microtubules dans les cellules animales, impliqués dans la division, la motilité, la polarité cellulaire. Ils participent à l'élaboration du fuseau mitotique, qui permet la séparation des chromosomes dans les cellules filles.
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PLK4, a potential target against AML

Blood, 2023
openaire   +2 more sources