Results 181 to 190 of about 4,153 (193)

PLK4 is essential for meiotic resumption in mouse oocytes.

Biology of reproduction, 2015
Polo-like kinase (PLK) 4 is a unique member of the PLK family that plays vital roles in centriole biogenesis during mitosis. The localization of PLK4 on centrioles must be precisely regulated during mitosis to ensure correct centriole duplication. However, little is known about the function of PLK4 in mammalian oocyte meiosis.
Yi-Bo, Luo, Nam-Hyung, Kim
openaire   +1 more source

Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer

European Journal of Medicinal Chemistry, 2022
Yu Sun, Tianxiao Wu, Wenbo Yin
exaly  

Structure-based discovery of 1-(3-fluoro-5-(5-(3-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)-3-(pyrimidin-5-yl)urea as a potent and selective nanomolar type-II PLK4 inhibitor

European Journal of Medicinal Chemistry, 2022
Tianxiao Wu, Wenbo Yin, Yixiang Sun
exaly  

plk4

2018
openaire   +1 more source

PLK4/SAK

2018
openaire   +1 more source

Plk4/SmSak

2018
openaire   +1 more source

Plk4 and Plk5

2018
openaire   +1 more source

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

Molecular Biology Reports, 2014
Kazuya Shinmura, Nobuya Kurabe, Masanori Gotō   +2 more
exaly  

CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis

Current Biology, 2016
Sihem Zitouni, Maria E Francia, Susana Montenegro Gouveia   +2 more
exaly  

Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

Developmental Cell, 2019
Carole Pennetier, John M Ryniawec, Daniel W Buster   +2 more
exaly