Results 161 to 170 of about 53,758 (224)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Pluripotent stem cell‐derived extracellular vesicles: Cell type‐dependent effect on tumorigenicity in cancer cell lines

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Abstract Extracellular vesicles (EVs) derived from pluripotent stem cells have been reported to reprogram cancer cells to a more benign phenotype, due to its provision of an embryonic microenvironment. Here, we show that the effect of the EVs on the tumorigenicity of the cancer cell lines is cell type‐dependent.
Chan Du, Karthikeyan Narayanan, Amudha Ganapathy, Andrew C. A. Wan   +3 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

A Novel Cell‐Penetrating Lipopeptide for DNA Binding, Self‐Assembly, and Delivery Into HeLa and Pluripotent Stem Cells

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
A lipopeptide is designed that contains an epitope from simian virus T‐antigen (SV40T, PKKKRKV) conjugated to an N‐terminal palmitoyl (C16‐) moiety, which acts as a cell‐penetrating lipopeptide, with additional aggregation propensity conferred by the lipid chain. The lipopeptide enables DNA delivery into the cytoplasm and nucleus.
Lucas R. de Mello, Tâmisa Seeko Bandeira Honda, Valeria Castelletto, Patrícia Terra Alves, Sang Won Han, Emerson Rodrigo da Silva, Ian W. Hamley   +6 more
wiley   +1 more source

RB1 inactivation in cutaneous carcinomas

Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source

Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome

Immunology, Volume 177, Issue 3, Page 596-612, March 2026.
Decreased fetal brain macrophages were previously reported in Ts1Cje mice, a model of Down syndrome (DS). We confirmed the reduction in primitive macrophages, brain macrophage precursors, using Ts1Cje‐derived mouse embryonic stem cells (Ts1Cje‐mESCs) and human induced pluripotent stem cells with trisomy 21 (Tri21‐hiPSCs), with in vivo validation ...
Koki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata   +9 more
wiley   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT The thymus is emerging as a model for studying organ regeneration and stem cell biology. While research has long focused on how antigen‐presenting cells shape the T cell repertoire, recent discoveries unveil a far richer cellular landscape that challenges long‐held views of thymus structure and function. This review traces the history of early
Roberta Ragazzini, Paola Bonfanti
wiley   +1 more source

Pathogenic fungus Ustilago maydis exploits the lateral root regulators to induce pluripotency in maize shoots

New Phytologist, Volume 249, Issue 6, Page 2974-2985, March 2026.
Summary Biotrophic plant–pathogens secrete effector molecules to redirect and exploit endogenous signaling and developmental pathways in their favor. The biotrophic fungus Ustilago maydis causes galls on all aerial parts of maize. However, the responsible gall‐inducing effectors and corresponding plant signaling pathway(s) remain largely unknown. Using
Mamoona Khan, Nithya Nagarajan, Kathrin Schneewolf, Caroline Marcon, Danning Wang, Frank Hochholdinger, Peng Yu, Armin Djamei   +7 more
wiley   +1 more source