Results 171 to 180 of about 111,548 (274)

Slow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speed. [PDF]

Sci Adv
Martín-Vírgala S, Segura J, Gallego A, Tong R, Tur-Gracia S, Rodriguez-Aguilera JR, Das B, Isoler-Alcaraz J, Gallego-García C, Shinde S, Maslon MM, Chabes A, Schermelleh L, Gómez M.   +13 more
europepmc   +1 more source

Endogenous VEGF signaling acts as a guardian of human primed pluripotency. [PDF]

Nat Commun
Wu X, Wen C, Zhu C, Jiao H, Xin C, Jiang H, Tong R, Huang Y, Yuan L, Shao M, Zhao H, Gu J, Wu Q, Zhang F, Wang H, Zhou Y, Liao B, Li L, Jin Y, Li H.   +19 more
europepmc   +1 more source

Bright Ferritin for Non‐Invasive MRI Monitoring of the Fate of Transplanted hPSC‐Cardiomyocytes in the Infarcted Rat Heart

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 323-338, July 2026.
ABSTRACT Purpose To demonstrate that a recently reported bright ferritin magnetic resonance imaging (MRI) platform can track transplanted human pluripotent stem cell (hPSC)‐derived cardiomyocytes (hPSC‐CMs) longitudinally and on‐demand in the rat heart.
Keyu Zhuang, Faisal J. Alibhai, Beiping Qiang, Rocco Romagnuolo, Kyle D. W. Vollett, Bradley K. C. Freeman, M. Juliana Gomez‐Garcia, Tamilla Sadikov Valdman, Tameshwar Ganesh, Yu‐Qing Zhou, Hai‐Ying Mary Cheng, Michael A. Laflamme, Hai‐Ling Margaret Cheng   +12 more
wiley   +1 more source

mRNA-Lipid Nanoparticle-Mediated Reprogramming and Standard Sendai Virus Reprogramming: Generation of iPSCs and iPSC-Derived Cardiomyocytes. [PDF]

Int J Mol Sci
DeBose M, Choi J, Ding D, Griggs AG, Gollatz EM, Scislowicz E, Harbuzariu A, Itzhaki I.   +7 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, Volume 16, Issue 6, Page 1102-1114, June 2026.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

EpCAM supports exit from pluripotency of embryonic stem cells via Eomes. [PDF]

Cell Death Dis
Gong N, Gouda M, Balaz AM, Song J, Kranz G, Hess J, Baumeister P, Unger K, Katalina V, Canis M, Gires O.   +10 more
europepmc   +1 more source

δ‐Tocotrienol Inhibits Migration and Reduces Chemoresistance in Ovarian Cancer Stem‐Like Cells

eFood, Volume 7, Issue 3, June 2026.
δ‐Tocotrienol targets ovarian cancer stem cell populations and suppresses stem‐like traits, migration, and chemoresistance, with concomitant downregulation of Akt and NF‐κB signaling. ABSTRACT Ovarian cancer (OC) is the most lethal form of gynecologic malignancies, due to its intrinsic chemoresistance and ability to relapse.
Gaia Giannitti, Sara Marchesi, Riccardo Garavaglia, Ivan Preosto, Fabrizio Fontana   +4 more
wiley   +1 more source

Feeder-free yet still naïve: improved method for capturing human pluripotent stem cells. [PDF]

EMBO J
Yagi M, Hochedlinger K.
europepmc   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

NSD1 governs H3K36me2-mediated DNA methylation and drives endo-mesodermal differentiation of human iPSCs. [PDF]

Clin Epigenetics
Hansknecht A, Mankarious M, Baranda MV, Torlak ED, Wagner W, Zeevaert K, Puri D.   +6 more
europepmc   +1 more source