Results 161 to 170 of about 62,870 (256)

Maternal Med12 safeguards trophoblast pluripotency and placental development. [PDF]

Biol Reprod
Halstead MM, Goad J, Khan A, Febbo O, Deshmukh R, Rajkovic A.   +5 more
europepmc   +1 more source

Kinematic‐calcium loops unravel impaired excitation–contraction coupling in MELAS‐affected cardioids

The Journal of Physiology, EarlyView.
Abstract figure legend Representation of kinematic and calcium transient loop with respect to traditional time coplotting. Abstract Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart.
Margherita Burattini, Annalinda Pisano, Maria Gemma Pignataro, Giulia d'Amati, Silvana Pinelli, Minh Long Hoang, Francesco Paolo Lo Muzio, Michele Miragoli   +7 more
wiley   +1 more source

Structure Variations and 3D Genome Disruption: Implications in Safety of hPSC-Based Cell Therapy. [PDF]

Int J Mol Sci
Li M, Cui F, Na T, Ma Q, Guo M, Guo M, Zhang K, Meng S.   +7 more
europepmc   +1 more source

The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
We found that SOCS3 deficiency activates STAT3 to enhance glioma stem cell (GSC) stemness and survival. We demonstrated that IL‐6 rescues STAT3 signaling and reverses SOCS3‐mediated tumor suppression. We revealed that SOCS3‐low GSCs exhibit enriched p53 and JAK‐STAT pathway activity. This study provides new mechanistic insights into SOCS3‐STAT3 axis in
Jingtao Wang, Gaolei Hou, Zhaofei Song, Kai Gao, Hongbin Wang, Tao Li   +5 more
wiley   +1 more source

Low oxygen environment alters transcripts related to energy metabolism without altering the pluripotency core of bovine embryonic stem cells. [PDF]

Biol Open
Botigelli RC, Arcanjo RB, Guiltinan C, Morton AJ, Smith JM, Denicol AC.   +5 more
europepmc   +1 more source

Report on the 13th international workshop on the CCN family of genes and inaugural ARBIOCOM conference, Nice, France

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Celebration of the 13th ICCNS meeting joint to the 1st ARBIOCOM Conference held on the site of Nice in December 2025. Abstract The 13th International Workshop on the CCN Family of Genes, held in Nice as part of the inaugural ARBIOCOM World Conference, brought together investigators with diverse research backgrounds, disciplines, and expertise. Building
Bernard Perbal, Ralf Weiskirchen, Annick Perbal, Brahim Chaqour   +3 more
wiley   +1 more source

Endogenous VEGF signaling acts as a guardian of human primed pluripotency. [PDF]

Nat Commun
Wu X, Wen C, Zhu C, Jiao H, Xin C, Jiang H, Tong R, Huang Y, Yuan L, Shao M, Zhao H, Gu J, Wu Q, Zhang F, Wang H, Zhou Y, Liao B, Li L, Jin Y, Li H.   +19 more
europepmc   +1 more source

Executive Function and Epigenetic Markers in Youth Exposed to Family and Community Violence in Childhood

Developmental Psychobiology, Volume 68, Issue 5, September 2026.
ABSTRACT Although exposure to violence has been linked to executive functioning impairments, the biological mechanisms underlying this association remain unclear. This study examined CpG sites associated with executive functions in 78 young adults and their links to family (psychological and physical) and community violence during childhood. The scales
Renata Queiroz Ramos, Cosme Marcelo Furtado Passos da Silva, Adriane Feijó Evangelista, Fernanda Serpeloni, Natasha Reis Lacerda, Joviana Quintes Avanci, Simone Gonçalves de Assis   +6 more
wiley   +1 more source

EpCAM supports exit from pluripotency of embryonic stem cells via Eomes. [PDF]

Cell Death Dis
Gong N, Gouda M, Balaz AM, Song J, Kranz G, Hess J, Baumeister P, Unger K, Katalina V, Canis M, Gires O.   +10 more
europepmc   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, Volume 46, Issue 9, Page 3164-3176, September 2026.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source