Results 191 to 200 of about 111,548 (274)

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Rheostats, not switches: Nuclear receptor dosage tunes somatic-to-iPSC reprogramming. [PDF]

Stem Cell Reports
Chronis C.
europepmc   +1 more source

ZMYM2 inhibits NANOG-mediated reprogramming [version 1; peer review: 2 approved, 1 approved with reservations] [PDF]

, 2019
Adams, David J, Lawrence, Moyra, Lombard, Patrick, Silva, Jose C.R., Theunissen, Thorold W   +4 more
core   +1 more source

Zinc‐Coordination‐Driven Pyroptosis Nano‐Inductor Sensitizes Colorectal Cancer Chemo‐Immunotherapy by Specific Delivery and Cell Stemness Suppression

MedComm – Oncology, Volume 5, Issue 2, June 2026.
CD44‐targeted CNPs co‐deliver Zn2+ and MIT–ALA to CRC cells. Intracellularly, Zn2+ inhibits GLUT1‐dependent glycolysis, and ALA disrupts mitochondrial function, driving metabolic exhaustion in CSCs. This mitochondrial damage primes GSDMD‐mediated pyroptosis, accompanied by the release of pro‐inflammatory cytokines (IL‑1β, IL‑18).
Qinxia Chang, Wenting Cheng, Hailong Tian, Siyuan Qin, Yaying Zhang, Jing Zuo, Wenbing Pu, Shuaijun Lu, Na Xie   +8 more
wiley   +1 more source

Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state. [PDF]

Genes Dev
Zhang T, Marina RJ, Prinjha R, Adelman K, Tarakhovsky A.   +4 more
europepmc   +1 more source

Genome‐wide association studies of a pea germplasm reveal novel markers and candidate genes implicated in resistance to Fusarium oxysporum f. sp. pisi races 1 and 2

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Pea (Pisum sativum L.) is an essential legume crop cultivated globally as food and feed. However, its production is greatly constrained by Fusarium oxysporum f. sp. pisi (Fop). Breeding for resistance is the most efficient management strategy, but the genetic foundation of Fop resistance remains unclear.
Osman Zakaria Wohor, Diego Rubiales, Nicolas Rispail   +2 more
wiley   +1 more source

Gene Expression at the Pluripotency Stage Predicts Pancreatic Endocrine Differentiation in iPSC Clones. [PDF]

Stem Cell Rev Rep
Zamarian V, Monaco L, Marras M, Ceriani C, Pellegrini S, Piemonti L, Sordi V.   +6 more
europepmc   +1 more source

Skin Boosters: 2026 Updated

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi, Hyunggyu Kang, Jong Keun Song, Olena Sydorchuk, Jeremy B. Green, Hugues Cartier, Roya Zarmehr Zamin, Benjamin Ascher   +7 more
wiley   +1 more source

The Regulatory Role of m⁶A Modification in the Function and Signaling Pathways of Animal Stem Cells. [PDF]

Cells
Yang X, Xu Y, Zhu S, Wang M, Cao H, Lu L.   +5 more
europepmc   +1 more source

Correction: Long range inter-chromosomal interaction of Oct4 distal enhancer loci regulates ESCs pluripotency. [PDF]

Cell Death Discov
Moon BS, Huang D, Gao F, Cai M, Lyu G, Zhang L, Chen J, Lu W.   +7 more
europepmc   +1 more source