Results 211 to 220 of about 83,579 (259)

BMP4 and FGF2 promote heterogeneous priming including extraembryonic lineages in porcine expanded potential stem cells. [PDF]

Front Cell Dev Biol
Kim H, Cai L, Hyun SH, Kim E.
europepmc   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, Volume 67, Issue 10, Page 5514-5530, October 2026.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Pilot study: The effect of eight weeks of aerobic training in the two phases of light and dark circadian rhythm on genes (OCT4, NANOG, SOX2, REX1) in bone tissue of diabetic mice. [PDF]

PLoS One
Janbozorgi M, Taheri A, Hosseinzadeh M, Ghafaripur S.   +3 more
europepmc   +1 more source

Human erythroid models of sickle cell disease

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract Sickle cell disease (SCD) is a group of severe inherited red blood cell disorders causing a major global healthcare burden. Despite recent advances in gene therapy and stem cell transplantation, treatment options remain very limited, highlighting the urgent need for the development of new therapeutic approaches.
Deborah E. Daniels, Maria A. Lizarralde‐Iragorri, Fatima O. Oyawoye, David C. Rees, Jan Frayne, Sara El Hoss   +5 more
wiley   +1 more source

Novel feeder-cell-free 3C system promotes the transition from primed to formative pluripotency, self-renewal, and germline differentiation in rabbit embryonic stem cells <i>in vitro</i>. [PDF]

Front Cell Dev Biol
Chen X, Liu Z, Li Q, Ullah R, Gao Y, Wang X, Liu L, Du F.   +7 more
europepmc   +1 more source

Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Heparin augments EV yield in culture by inhibiting EV binding to cell‐surface HSPG and masking EV surface. Preventing autocrine and homotypic paracrine EV uptake during cell culture results in EV accumulation and higher yield. Heparin improved EV recovery after storage in NaCl but not in complex media or protein‐rich buffer(Please see Figure 9 for ...
André Cronemberger Andrade, Rodolphe Poupardin, Martin Wolf, Liliia Paniushkina, Karim Selmi, Deepika Kundully Suresh, Nicole Maeding, Heide‐Marie Binder, Janine Zwicklhuber, Sarah Hochmann, André Görgens, Samir El Andaloussi, Katharina Schallmoser, Dirk Strunk   +13 more
wiley   +1 more source

Temporal dynamics of intragenic enhancer RNAs regulate Lin28a expression in response to external stimuli in embryonic stem cells. [PDF]

Nucleic Acids Res
Lee H, Oh M, Moon J, Jeong S, Jang Y, Lee MH, Um D, Lee D, Kim TK, Kim SK.   +9 more
europepmc   +1 more source

CRISPR/Cas9‐Mediated Correction of the SLC25A38 Mutation in a Patient With Sideroblastic Anemia

The Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
In this study, the identity of fibroblast cells isolated from the patient was identified using several methods. Then, the sgRNA3‐pX459 plasmid together with ssODN was transfected into fibroblast cells with a transfection efficiency of 49.64%. Finally, the entry of ssODN donor into fibroblast cells was confirmed using PCR‐RFLP and PAGE methods. ABSTRACT
Shokoufeh Yazdanparast, Hamid Galehdari, SaeidReza Khatami, Elham Hoveizi, Kaveh Jaseb   +4 more
wiley   +1 more source

A regenerative strategy for vital pulp therapy: Platelet-rich fibrin augments stem cell viability and pluripotency in bioactive cement environments. [PDF]

Biochem Biophys Rep
Pourmohammadi-Nejad F, Irannezhad A, Abazarpour R, Abedi P, Yousefi-Ahmadipour A.   +4 more
europepmc   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source