Results 221 to 230 of about 83,579 (259)

Author Correction: Cryopreservable dopaminergic progenitors derived from human iPSCs with accelerated loss of pluripotency and early functional restoration in Parkinsonian rats. [PDF]

NPJ Parkinsons Dis
Chang CY, Chiang CY, Ting HC, Tsai YJ, Chan PC, Chen MF, Guo YT, Liu YH, Chen YS, Chuang CH, Lin PC, Chuang LH, Huang MH, Tung YC, Chen PY, Harn HJ, Su HL, Lin SZ.   +17 more
europepmc   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

The Journal of Pathology, Volume 270, Issue 2, Page 226-240, October 2026.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch, RM Verdijk, H Fadlelseed, TPP van den Bosch, S Owens, S Kennedy, E Kilic, E Brosens   +7 more
wiley   +1 more source

Stem cell activity is linked to a transient acquisition of pluripotency during callus proliferation. [PDF]

Nat Commun
Bae SH, Park OS, Lee K, Lee HG, Jang SY, Hwang GS, Noh YS, Seo PJ.   +7 more
europepmc   +1 more source

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

Integration of the naive pluripotency gene network with the response to GSK3 inhibition by Tcf7l1-driven enhancer decommissioning. [PDF]

Stem Cell Reports
Kwon J, Zhang JY, Shy BR, MacDougall MS, Leung EHW, Chronis C, Gounari F, Merrill BJ.   +7 more
europepmc   +1 more source

Protracted Fate Acquisition and Epigenetic De‐Aging During Induced Neural Stem Cell Conversion of Human Blood Cells

Aging Cell, Volume 25, Issue 10, October 2026.
In contrast to rapid epigenetic de‐aging during induced pluripotent stem cell generation, direct conversion of blood cells into neural stem cells is associated with largely protracted epigenetic de‐aging. The process coincides with prolonged cell fate consolidation, does not require sustained proliferation, and might provide experimental access to ...
Lea Jessica Berg, Julia Franzen, Andreas Buness, Rachel Konang, Chao Sheng, Michael Peitz, Andreas Till, Wolfgang Wagner, Oliver Brüstle   +8 more
wiley   +1 more source

Advances in porcine stem cell research and their applications in agriculture. [PDF]

Front Cell Dev Biol
Pei Y, Zhou R.
europepmc   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source