Results 241 to 250 of about 111,548 (274)
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Nature Methods, 2010
Retroviral marking of single human embryonic stem cells shows that cultures of these cells contain subpopulations with distinct functional properties.
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Retroviral marking of single human embryonic stem cells shows that cultures of these cells contain subpopulations with distinct functional properties.
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2013
The molecular and phenotypic irreversibility of mammalian cell differentiation was a fundamental principle of developmental biology at least until the 1980s, despite numerous reports dating back to the 1950s of the induction of pluripotency in amphibian cells by nuclear transfer (NT).
Corey, Heffernan +6 more
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The molecular and phenotypic irreversibility of mammalian cell differentiation was a fundamental principle of developmental biology at least until the 1980s, despite numerous reports dating back to the 1950s of the induction of pluripotency in amphibian cells by nuclear transfer (NT).
Corey, Heffernan +6 more
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2019
Humans develop from a unique group of pluripotent cells in early embryos that can produce all cells of the human body. While pluripotency is only transiently manifest in the embryo, scientists have identified conditions that sustain pluripotency indefinitely in the laboratory.
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Humans develop from a unique group of pluripotent cells in early embryos that can produce all cells of the human body. While pluripotency is only transiently manifest in the embryo, scientists have identified conditions that sustain pluripotency indefinitely in the laboratory.
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Advances in Reprogramming to Pluripotency
Current Stem Cell Research & Therapy, 2015Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy.
Alateeq, Suad +2 more
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Nuclear reprogramming and pluripotency
Nature, 2006The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism.
Konrad, Hochedlinger, Rudolf, Jaenisch
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The reprogramming language of pluripotency
Current Opinion in Genetics & Development, 2008In metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable of reprogramming a somatic nucleus
Welstead, G Grant +2 more
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Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency
Cell Stem Cell, 2021Masaki Kinoshita +2 more
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Ground rules of the pluripotency gene regulatory network
Nature Reviews Genetics, 2017Mo Li, Juan Carlos Izpisúa Belmonte
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Control of ground-state pluripotency by allelic regulation of Nanog
Nature, 2012Maria-Elena Torres-Padilla
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