Results 81 to 90 of about 998,979 (405)
Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing
Non-coding RNA Research, 2017 In recent years, different studies have revealed that adult mammalian cardiomyocytes have the capacity to self-renew under homeostatic conditions and after myocardial injury.
Elena Garreta +3 more
doaj
Cellular network entropy as the energy potential in Waddington's differentiation landscape [PDF]
Scientific Reports (2013) 3, 3039, 2013 Differentiation is a key cellular process in normal tissue development that is significantly altered in cancer. Although molecular signatures characterising pluripotency and multipotency exist, there is, as yet, no single quantitative mark of a cellular sample's position in the global differentiation hierarchy. Here we adopt a systems view and consider
arxiv +1 more source
Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. [PDF]
, 2015 Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits.
Biswas, Sangita +5 more
core +3 more sources
Nature Communications, 2020 Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD).
D. Doi +10 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
Сибирский научный медицинский журнал, 2019 Stem cells are divided into embryonic and adult stem cells. The relevance of the use of stem cells in clinical practice has received new evidence in recent years however, the methods of obtaining stem cells for medical purposes cause ethical rejection ...
A. V. Korel, S. B. Kuznetsov
doaj +1 more source
A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues [PDF]
, 2014 Embryonic stem cells and induced pluripotent stem cells have emerged as the gold standard of pluripotent stem cells and the class of 10 stem cell with the highest potential for contribution to regenerative and therapeutic application; however, their ...
Ariel A Simerman +10 more
core +1 more source
Telomere regulation in pluripotent stem cells [PDF]
Protein & Cell, 2014 Pluripotent stem cells (PSCs) have the potential to produce any types of cells from all three basic germ layers and the capacity to self-renew and proliferate indefinitely in vitro. The two main types of PSCs, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), share common features such as colony morphology, high expression of Oct4
Zhou Songyang +5 more
openaire +3 more sources
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
wiley +1 more source
Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis
Cellular & Molecular Biology LettersGlucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver.
Yasmin Abu Aqel +6 more
doaj +1 more source