PML-II regulates ERK and AKT signal activation and IFNα-induced cell death [PDF]
Cell Communication and Signaling, 2021 Background The requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. However, the exact mechanisms by which the multiple isoforms of PML protein participate in this process remain not well ...
Xueqiong Meng +3 more
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Acute Promyelocytic Leukemia: Pathophysiology, Diagnosis and Clinical Management [PDF]
Hematology ReportsBackground/Objectives: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by the t(15;17)(q24;q21) translocation, generating the PML::RARA fusion gene that blocks myeloid differentiation and drives ...
Meryeme Abddaoui +3 more
doaj +2 more sources
ATRX Promotes Transcription Initiation of HSV-1 Immediate Early Genes During Early Lytic Infection [PDF]
VirusesHerpes simplex virus 1 (HSV-1) transcribes its genome using host RNA polymerase II (Pol II) in a temporally regulated cascade. We previously proposed a model of Transient Immediate Early gene Mediated Repression (TIEMR), in which early repression of ...
Laura E. M. Dunn +2 more
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Molecular characterization of JC virus in progressive multifocal leukoencephalopathy cases from India [PDF]
Scientific ReportsProgressive Multifocal Leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the central nervous system caused by reactivation of the John Cunningham virus (JCV) in immunocompromised individuals.
Gnana Soundari Palani +5 more
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Venetoclax induces mitochondrial apoptosis and autophagy to overcome arsenic trioxide resistance in acute promyelocytic leukemia [PDF]
Journal of Translational MedicineBackground Arsenic trioxide (ATO) therapy is highly successful in majority of acute promyelocytic leukemia (APL) patients with PML-RARA fusion oncoprotein. However, after initial response to therapy, 8–10% experienced relapse and became resistant to ATO.
Deepshikha Dutta +18 more
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Dissecting the role of PML-II in gene transcription and in IFN alpha-mediated apoptosis [PDF]
Multiple isoforms of promyelocytic leukaemia protein (PML) participate in various cellular activities including innate immune responses, gene transcription and cell apoptosis. Recent work in our laboratory demonstrated PML isoform II (PML-II) was required for type I interferon (IFN) and IFN-stimulated gene (ISG) transcription by regulating ...
Meng, Xueqiong
openaire +2 more sources
JC Virus Agnogene Regulates Histone-Modifying Enzymes via PML-NBs: Transcriptomics in VLP-Expressing Cells [PDF]
VirusesJC virus (JCV) replicates within the nuclei of glial cells in the human brain and causes progressive multifocal leukoencephalopathy. JCV possesses a small, circular, double-stranded DNA genome, divided into early and late protein-coding regions.
Yukiko Shishido-Hara, Takeshi Yaoi
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Gene Expression of Promyelocytic Leukemia Proteins and IFN-γ Is Reduced in Rotavirus-Infected Children [PDF]
Iranian Biomedical Journal, 2020 Background: Rotavirus infection is one of the most common gastroenteritis in the world, and a million cases are registered to enter hospital every year.
Ahmed Jasim Mohammed +2 more
doaj +2 more sources
Viruses, 2023 Upon viral entry, components of ND10 nuclear bodies converge with incoming DNA to repress viral expression. The infected cell protein 0 (ICP0) of herpes simplex virus 1 (HSV-1) contains a RING-type E3 ubiquitin ligase that targets the ND10 organizer, PML,
Behdokht Jan Fada +6 more
doaj +1 more source
Robust Vector BOTDA Signal Processing with Probabilistic Machine Learning
Sensors, 2023 This paper presents a novel probabilistic machine learning (PML) framework to estimate the Brillouin frequency shift (BFS) from both Brillouin gain and phase spectra of a vector Brillouin optical time-domain analysis (VBOTDA).
Abhishek Venketeswaran +5 more
doaj +1 more source