Results 21 to 30 of about 15,930 (228)

Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection

mBio, 2017
The promyelocytic leukemia protein (PML) is the main organizer of stress-responsive subnuclear structures called PML nuclear bodies. These structures recruit multiple interactors and modulate their abundance or their posttranslational modifications ...
David Ribet, Valérie Lallemand-Breitenbach, Omar Ferhi, Marie-Anne Nahori, Hugo Varet, Hugues de Thé, Pascale Cossart   +6 more
doaj   +1 more source

Interaction of the Adenovirus Type 5 E4 Orf3 Protein with Promyelocytic Leukemia Protein Isoform II Is Required for ND10 Disruption [PDF]

, 2006
Nuclear domain 10 (ND10s), or promyelocytic leukemia protein (PML) nuclear bodies, are spherical nuclear structures that require PML proteins for their formation. Many viruses target these structures during infection. The E4 Orf3 protein of adenovirus 5 (
Anne Hoppe, Stephanie J. Beech, John Dimmock, Keith N. Leppard   +3 more
core   +1 more source

A promyelocytic leukemia protein-thrombospondin 2 axis and the risk of relapse in neuroblastoma [PDF]

, 2016
Purpose. Neuroblastoma is a childhood malignancy originating from the sympathetic nervous system with a complex biology, prone to metastasize and relapse. High-risk, metastatic cases are explained in part by amplification or mutation of oncogenes such as
Anderson, J., Anderson, J., Bagella, L., Bagella, L., Barton, A., Barton, A., Brindle, N., Brindle, N., Burns, A.J., Burns, A.J., Cantilena, S., Cantilena, S., Chakelam, S., Chakelam, S., Chayka, O., Chayka, O., De The, H., De The, H., Dvorkina, M., Dvorkina, M., Hodivala-Dilke, K., Hodivala-Dilke, K., Lebras, M., Lebras, M., Lechertier, T., Lechertier, T., Leite, A.P., Leite, A.P., Montano, X., Montano, X., Morgenstern, D., Morgenstern, D., Nieddu, V., Nieddu, V., Pezzolo, A., Pezzolo, A., Pistoia, V., Pistoia, V., Pistorio, A., Pistorio, A., Regad, T., Regad, T., Sala, A., Sala, A., Salomoni, P., Salomoni, P., Saunders N.J., Saunders N.J., Sebire, N., Sebire, N., Sementa, A.R., Sementa, A.R., Virasami, A., Virasami, A.   +53 more
core   +2 more sources

MOLECULAR PATHOGENESIS OF SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA

Mediterranean Journal of Hematology and Infectious Diseases, 2011
Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia.
Melanie Joannides, Ashley N Mays, Anita R Mistry, Syed Khizer Hasan, Andreas Reiter, Joseph L Wiemels, Carolyn A Felix, Francesco Lo-Coco, Neil Osheroff, Ellen Solomon, David Grimwade   +10 more
doaj   +3 more sources

A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes [PDF]

, 2014
Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate.
Box, Andrew C., Davido, David J., Haug, Jeffrey S., Lane, William S., Smith, Miles C.   +4 more
core   +3 more sources

Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARα-positive leukemic stem cells

Haematologica, 2007
Background and Objectives Stem cells play an important role in the pathogenesis and maintenance of most malignant tumors. Acute myeloid leukemia (AML) is a stem cell disease.
Xiaomin Zheng, Anita Seshire, Brigitte Rüster, Gesine Bug, Tim Beissert, Elena Puccetti, Dieter Hoelzer, Reinhard Henschler, Martin Ruthardt   +8 more
doaj   +1 more source

Does Extended Interval Dosing Natalizumab Preserve Effectiveness in Multiple Sclerosis? A 7 Year-Retrospective Observational Study

Frontiers in Immunology, 2021
The extended interval dosing (EID) of natalizumab has been suggested to be associated with a reduced risk of progressive multifocal leukoencephalopathy (PML) and short-term preservation of efficacy but its long-term effectiveness remain unknown. We aimed
Javier Riancho, Javier Riancho, Javier Riancho, Javier Riancho, Sonia Setien, Jose Ramón Sánchez de la Torre, Marta Torres-Barquin, Mercedes Misiego, José Luis Pérez, Tamara Castillo-Triviño, Tamara Castillo-Triviño, Cristina Menéndez-García, Manuel Delgado-Alvarado, Manuel Delgado-Alvarado   +13 more
doaj   +1 more source

Role of salivary biomarkers in early detection of oral squamous cell carcinoma

Indian Journal of Pathology and Microbiology, 2017
Introduction: Oral cancer is prevalent worldwide and is a common cause of morbidity and mortality. Despite advances in treatment, the survival of patients with oral cancer has not significantly improved over the past several decades owing to late ...
Nidhi Awasthi
doaj   +1 more source

Induction of AML Preleukemic Fusion Genes in HSPCs and DNA Damage Response in Preleukemic Fusion Gene Positive Samples

Antioxidants, 2021
Preleukemic fusion genes (PFGs) occurring after DNA damage in hematopoietic stem progenitor cells (HSPCs) in utero often represent the initial event in the development of childhood leukemia.
Pavol Kosik, Matus Durdik, Milan Skorvaga, Daniela Klimova, Dominika Kochanova, Zlatica Cerna, Miroslav Kubes, Marek Holop, Igor Belyaev   +8 more
doaj   +1 more source

Mitral valve restoration using the No-React(R) MitroFix™: a novel concept

Journal of Cardiothoracic Surgery, 2012
Background Mitral Valve Repair (MVRP) has been shown to be significantly superior to Mitral Valve Replacement (MVR). Since the majority of repairs involve the Posterior Mitral Leaflet (PML) and not the Anterior Mitral Leaflet (AML), the ...
Oertel Frank, Golczyk Karl, Pantele Sigrun, Danov Vladimir, Galiñanes Manuel, Beyer Michael   +5 more
doaj   +1 more source