Results 1 to 10 of about 43,079 (212)

Characterization and functional analysis of chicken promyelocytic leukemia protein [PDF]

Poultry Science
: In mammals, promyelocytic leukemia (PML) protein, also named as TRIM19, is the key component of nuclear membrane-less sub structures PML nuclear bodies (PML-NB) or nuclear domains 10 (ND10). PML-NBs are dynamic foci that consist of numerous permanently
Shengnan Wang, Jingwen Li, Tiantian Miao, Tuofan Li, Zhimin Wan, Quan Xie, Hongxia Shao, Aijian Qin, Jianqiang Ye   +8 more
doaj   +4 more sources

Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection [PDF]

mBio, 2017
The promyelocytic leukemia protein (PML) is the main organizer of stress-responsive subnuclear structures called PML nuclear bodies. These structures recruit multiple interactors and modulate their abundance or their posttranslational modifications ...
David Ribet, Valérie Lallemand-Breitenbach, Omar Ferhi, Marie-Anne Nahori, Hugo Varet, Hugues de Thé, Pascale Cossart   +6 more
doaj   +8 more sources

Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1. [PDF]

PLoS Pathogens, 2020
Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles are ...
Christina Paulus, Thomas Harwardt, Bernadette Walter, Andrea Marxreiter, Marion Zenger, Edith Reuschel, Michael M Nevels   +6 more
doaj   +7 more sources

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides. [PDF]

PLoS ONE, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez, Philipp Demmer, Elena Puccetti   +2 more
doaj   +8 more sources

Epstein - Barr virus latent membrane protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodies [PDF]

Virology Journal, 2011
The Epstein-Barr virus (EBV) encoded Latent Membrane Protein 1 (LMP1) has been shown to increase the expression of promyelocytic leukemia protein (PML) and the immunofluorescent intensity of promyelocytic leukemia nuclear bodies (PML NBs).
Flemington Erik K, Shan Bin, Chadwick Reid W, Block Gregory J, Sides Mark D, Lasky Joseph A   +5 more
doaj   +3 more sources

TGFβ-Mediated Overexpression of Podoplanin Serves as a Potential Diagnostic Biomarker in Acute Promyelocytic Leukemia. [PDF]

Mol Carcinog
ABSTRACT Early diagnosis of acute promyelocytic leukemia (APL), driven by PML‐RARA oncoprotein, is vital for survival, as delays can cause fatal coagulopathy without prompt therapeutic intervention of all‐trans retinoic acid and arsenic trioxide. Although APL is diagnosed using microscopy, immunophenotyping, and FISH/PCR for PML‐RARA, morphological ...
Maity A, Kumar R, Dutta M, Mishra A, Gawde J, Patil J, Kadam D, Mirgh S, Gokarn A, Jain H, Nayak L, Bagal B, Punatar S, Sengar M, Khattry N, Subramanian PG, Tembhare P, Hasan SK.   +17 more
europepmc   +2 more sources

Acute promyelocytic leukemia. State of the art

Iatreia, 2021
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) that results from a balanced translocation between chromosomes 15 and 17, which involves the gene encoding the retinoic acid receptor alpha (RARA) on chromosome 17 and the ...
Leonardo Mejía-Buriticá, José Domingo Torres-Hernández, Gonzalo de Jesús Vásquez   +2 more
doaj   +1 more source

Biomolecular Condensates in Myeloid Leukemia: What Do They Tell Us?

HemaSphere, 2023
Recent studies have suggested that several oncogenic and tumor-suppressive proteins carry out their functions in the context of specific membrane-less cellular compartments.
Zivojin Jevtic, Melanie Allram, Florian Grebien, Juerg Schwaller   +3 more
doaj   +1 more source

Case Report: Identification of a novel LYN::LINC01900 transcript with promyelocytic phenotype and TP53 mutation in acute myeloid leukemia

Frontiers in Oncology, 2023
Acute myeloid leukemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells characterized by the abnormal proliferation of primitive and naive random cells in the bone marrow and peripheral blood. Acute promyelocytic leukemia (APL)
Chengjun Hu, Qiuxin Dai, Ruiyi Zhang, Huanping Yang, Man Wang, Kaili Gu, Jiangang Yang, Wenjun Meng, Ping Chen, Maozhong Xu   +9 more
doaj   +1 more source

The CEBPA gene is down-regulated in acute promyelocytic leukemia and its upstream promoter, but not the core promoter, is highly methylated

Haematologica, 2011
Impairment of CCAAT Enhancer Binding Protein alpha (CEBPA) function is a common finding in acute myeloid leukemia; nevertheless, its relevance for acute promyelocytic leukemia pathogenesis is unclear.
Bárbara Amélia Santana-Lemos, Ana Paula Alencar de Lima Lange, Mariana Tereza de Lira Benício, Thiago Donizete da Silva José, Antônio Roberto Lucena-Araújo, Alexandre Krause, Carolina Hassibe Thomé, Eduardo Magalhães Rego   +7 more
doaj   +1 more source