Results 21 to 30 of about 120,872 (251)
The promyelocytic leukemia zinc finger protein (PLZF): two decades of molecular oncology [PDF]
Frontiers in Oncology, 2012 The promyelocytic leukemia zinc finger protein (PLZF), also known as Zbtb16 or Zfp145, was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with the RARA ...
Bandar Ali Suliman +3 more
doaj +3 more sources
Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies [PDF]
International Journal of Biological Sciences, 2009 The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These cellular activities often rely on the localization of
Erin Reineke, H. Kao
semanticscholar +3 more sources
Promyelocytic Leukemia Protein (Pml) and Daxx Participate in a Novel Nuclear Pathway for Apoptosis [PDF]
Journal of Experimental Medicine, 2000 The promyelocytic leukemia protein (PML) gene of acute promyelocytic leukemia (APL) encodes a cell growth and tumor suppressor essential for multiple apoptotic signals.
S. Zhong +5 more
semanticscholar +2 more sources
Transcriptional Repression by the Promyelocytic Leukemia Protein, PML [PDF]
Experimental Cell Research, 1997 Acute promyelocytic leukemia is characterized by the presence of a t(15; 17) chromosomal translocation which results in the expression of a chimeric gene product, PMLRAR alpha, consisting of an N-terminal-truncated retinoic acid receptor-alpha fused to a C-terminal-truncated PML.
S, Vallian +6 more
openaire +4 more sources
The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis. [PDF]
Int J Biol Sci, 2015 The promyelocytic leukemia protein (PML) is the essential component of multi-protein sub-nuclear structures, the PML-Nuclear bodies (PML-NB, 1). The PML-NBs regulate a variety of nuclear functions, including post-translational modifications in nuclear proteins (acetylation, SUMOylation, ubiquitylation) 1.
Carracedo A +15 more
europepmc +6 more sources
Selective activation of NFAT by promyelocytic leukemia protein [PDF]
Oncogene, 2008 Promyelocytic leukemia (PML) protein is a tumor suppressor with complicated action mechanisms not yet fully understood. In this study, we found that the nuclear factor of activated T cell (NFAT) is an unexpected partner of PML: PML specifically enhanced the transcription activation of NFAT.
Y-H, Lo, C-C, Wu, H-M, Shih, M-Z, Lai
openaire +2 more sources
Acute promyelocytic leukemia. State of the art
Iatreia, 2021 Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) that results from a balanced translocation between chromosomes 15 and 17, which involves the gene encoding the retinoic acid receptor alpha (RARA) on chromosome 17 and the ...
Leonardo Mejía-Buriticá +2 more
doaj +1 more source
Promyelocytic Leukemia Proteins Regulate Fanconi Anemia Gene Expression [PDF]
International Journal of Molecular Sciences, 2021 Promyelocytic leukemia (PML) protein is the core component of subnuclear structures called PML nuclear bodies that are known to play important roles in cell survival, DNA damage responses, and DNA repair. Fanconi anemia (FA) proteins are required for repairing interstrand DNA crosslinks (ICLs).
Anudari Munkhjargal +6 more
openaire +3 more sources
The Promyelocytic Leukemia Protein Represses A20-mediated Transcription [PDF]
Journal of Biological Chemistry, 2002 The promyelocytic leukemia (PML) protein is a tumor suppressor that is disrupted by the chromosomal translocation t(15;17), a consistent cytogenetic feature of acute promyelocytic leukemia. A role of PML in multiple pathways of apoptosis was conclusively demonstrated using PML(-/-) animal and cell culture models.
Wen-Shu, Wu +2 more
openaire +5 more sources