Results 21 to 30 of about 43,079 (212)
Effects of Promyelocytic Leukemia Protein on Virus-Host Balance [PDF]
Journal of Virology, 2002 ABSTRACTThe cellular promyelocytic leukemia protein (PML) associates with the proteins of several viruses and in some cases reduces viral propagation in cell culture. To examine the role of PML in vivo, we compared immune responses and virus loads of PML-deficient and control mice infected with lymphocytic choriomeningitis virus (LCMV) and vesicular ...
Bonilla, Weldy V. +8 more
openaire +3 more sources
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML [PDF]
, 2002 HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may
AGUIARI, Gianluca +8 more
core +1 more source
The promyelocytic leukemia protein stimulates SUMO conjugation in yeast [PDF]
Oncogene, 2006 The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo to the small ubiquitin-like protein SUMO-1, altering its behavior and capacity to recruit other ...
B B, Quimby +4 more
openaire +2 more sources
Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia
Case Reports in Dermatology, 2012 Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression.
Sachiko Sakamoto +7 more
doaj +1 more source
PML nuclear body biogenesis and oligomerization-driven leukemogenesis
Blood Science, 2020 . PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm.
Yuwen Li, Xiaodan Ma, Guoyu Meng
doaj +1 more source
Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]
, 2017 Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo +23 more
core +4 more sources
Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity [PDF]
Immunity, 2009 Interferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diverse effects they elicit are not fully understood. Here, we identified the promyelocytic leukemia zinc finger (PLZF) protein as a previously unrecognized component of the IFN response.
Xu D +9 more
openaire +3 more sources
Haematologica, 2019 Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu +9 more
doaj +1 more source
A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]
, 2018 Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Duncavage, Eric J. +13 more
core +2 more sources
Regulation of NF-κB by PML and PML-RARα [PDF]
, 2017 Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar +8 more
core +1 more source