Results 21 to 30 of about 3,564,161 (186)

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Blood Advances, 2018
: The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that Hhex maintains leukemia stem cell self-renewal by enabling ...
Jacob T. Jackson, Ashley P. Ng, Benjamin J. Shields, Sue Haupt, Ygal Haupt, Matthew P. McCormack   +5 more
doaj   +1 more source

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J., Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, S., Wiesner, D., Duell, T., J. Mittermueller, D. Wiesner, S. Braun, H.M. Schmetzer, T. Duell, H.H. Gerhartz   +11 more
core   +1 more source

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Haematologica, 2019
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid ...
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng   +13 more
doaj   +1 more source

Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Life on Earth is constantly exposed to electromagnetic fields (EMFs) and the effects induced by EMFs on biological systems have been extensively studied producing different and sometimes contradictory results.
Alfredo Errico Provenzano, Stefano Amatori, Maria Gemma Nasoni, Giuseppe Persico, Sergio Russo, Anna Rita Mastrogiacomo, Alessandro Gambarara, Mirco Fanelli   +7 more
doaj   +1 more source

Molecular Mechanisms of the Antileukemia Activities of Retinoid and Arsenic

Journal of Pharmacological Sciences, 2014
.: Acute promyelocytic leukemia (APL) is characterized by the occurrence of translocations between chromosomes 15 and 17, resulting in generation of a fusion protein of promyelocytic leukemia (PML) and retinoid A receptor (RAR) α. APL cells are unable to
Takeaki Nitto, Kohei Sawaki
doaj   +1 more source

Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells [PDF]

, 1990
HL-60 leukemic cells were differentiated along the neutrophilic pathway with retinoic acid (RA) or along the monocytic pathway with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).
Seifert, Roland, Jungblut, P. R.
core   +1 more source

Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia [PDF]

, 2020
Simple SummaryIn solid tumors, the altered expression of embryonic genes such as the SLIT-ROBO family has been associated with poor prognosis, while little is known about their role in acute myeloid leukemia (AML).
Jan Jacob Schuringa, Arnold Ganser, Chauffaille, Maria de Lourdes, Kerbauy, Fabio, Keating, Armand, Maria de Lourdes Chauffaille, Melo, Raul A. M., Gloria, Ana B., Luíse A. A. Simões, Diego A. Pereira-Martins, Rosane I. Bittencourt, Martin S. Tallman, Richard Dillon, Isabel Weinhäuser, Koury, Luisa C., Lo-Coco, Francesco, Bianco, Thiago M., Emanuele Ammatuna, Nancy Berliner, Armand Keating, Francesco Lo-Coco, Antonio R. Lucena-Araujo, Silveira, Douglas R., Bob Löwenberg, Fábio Kerbauy, Katia Pagnano, Weinhauser, Isabel, Pereira-Martins, Diego A., Simoes, Luise A. A., Valk, Peter, Fagundes, Evandro M., Tallman, Martin S., Berliner, Nancy, Lucena-Araujo, Antonio R., Cesar Ortiz, Miguel A. Sanz, Douglas R. Silveira, Eduardo M. Rego, Sanz, Miguel A., Ana B. Gloria, Raul C. Ribeiro, Raul A. M. Melo, Elenaide C. Nunes, Evandro M. Fagundes, Pasquini, Ricardo, Rego, Eduardo M., Nunes, Elenaide C., Cleide L. Araujo, Araujo, Cleide L., Thiago M. Bianco, Ganser, Arnold, Schuringa, Jan Jacob, Luisa C. Koury, Ribeiro, Raul C., Weinhauser, Isabel; id_orcid, Ammatuna, Emanuele, Ortiz, Cesar, Bittencourt, Rosane I., Pagnano, Katia, Ricardo Pasquini, Dillon, Richard, Peter Valk, Lowenberg, Bob   +62 more
core   +2 more sources

RING tetramerization is required for nuclear body biogenesis and PML sumoylation

Nature Communications, 2018
Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear ...
Pengran Wang, Shirine Benhenda, Haiyan Wu, Valérie Lallemand-Breitenbach, Tao Zhen, Florence Jollivet, Laurent Peres, Yuwen Li, Sai-Juan Chen, Zhu Chen, Hugues de Thé, Guoyu Meng   +11 more
doaj   +1 more source

Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. [PDF]

PLoS ONE, 2013
Sirtuins, NAD-dependent protein deacetylases, play important roles in cellular functions such as metabolism and differentiation. Whether sirtuins function in tumorigenesis is still controversial, but sirtuins are aberrantly expressed in tumors, which may
Yoshitaka Sunami, Marito Araki, Yumi Hironaka, Soji Morishita, Masaki Kobayashi, Ei Leen Liew, Yoko Edahiro, Miyuki Tsutsui, Akimichi Ohsaka, Norio Komatsu   +9 more
doaj   +1 more source

Chlorination‐Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models

Angewandte Chemie, EarlyView.
A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho, Yongyang Luo, Jeehyeon Bae, Youngmi Kim   +3 more
wiley   +2 more sources