Results 41 to 50 of about 120,872 (251)

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J., Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, S., Wiesner, D., Duell, T.   +5 more
core   +1 more source

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
doaj   +1 more source

A role for cytoplasmic PML in cellular resistance to viral infection. [PDF]

PLoS ONE, 2008
PML gene was discovered as a fusion partner with retinoic acid receptor (RAR) alpha in the t(15:17) chromosomal translocation associated with acute promyelocytic leukemia (APL).
Beth A McNally, Joanne Trgovcich, Gerd G Maul, Yang Liu, Pan Zheng   +4 more
doaj   +1 more source

B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

Nature Communications, 2019
Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show
Yuwen Li, Xiaodan Ma, Zhiming Chen, Haiyan Wu, Pengran Wang, Wenyu Wu, Nuo Cheng, Longhui Zeng, Hao Zhang, Xun Cai, Sai-Juan Chen, Zhu Chen, Guoyu Meng   +12 more
doaj   +1 more source

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Blood Advances, 2018
: The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that Hhex maintains leukemia stem cell self-renewal by enabling ...
Jacob T. Jackson, Ashley P. Ng, Benjamin J. Shields, Sue Haupt, Ygal Haupt, Matthew P. McCormack   +5 more
doaj   +1 more source

PML protein expression in hematopoietic and acute promyelocytic leukemia cells [PDF]

Blood, 1993
Acute promyelocytic leukemia (APL) is thought to be caused by the t(15,17) translocation that fuses the PML gene to that of the retinoic acid receptor alpha (RAR alpha) and generates a PML/RAR alpha fusion protein. Yet, paradoxically, APL cells are exquisitely sensitive to retinoic acid (RA), as they terminally differentiate upon RA exposure.
M T, Daniel, M, Koken, O, Romagné, S, Barbey, A, Bazarbachi, M, Stadler, M C, Guillemin, L, Degos, C, Chomienne, H, de Thé   +9 more
openaire   +3 more sources

Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia [PDF]

, 2020
Simple SummaryIn solid tumors, the altered expression of embryonic genes such as the SLIT-ROBO family has been associated with poor prognosis, while little is known about their role in acute myeloid leukemia (AML).
Jan Jacob Schuringa, Arnold Ganser, Chauffaille, Maria de Lourdes, Kerbauy, Fabio, Keating, Armand, Maria de Lourdes Chauffaille, Melo, Raul A. M., Gloria, Ana B., Luíse A. A. Simões, Diego A. Pereira-Martins, Rosane I. Bittencourt, Martin S. Tallman, Richard Dillon, Isabel Weinhäuser, Koury, Luisa C., Lo-Coco, Francesco, Bianco, Thiago M., Emanuele Ammatuna, Nancy Berliner, Armand Keating, Francesco Lo-Coco, Antonio R. Lucena-Araujo, Silveira, Douglas R., Bob Löwenberg, Fábio Kerbauy, Katia Pagnano, Weinhauser, Isabel, Pereira-Martins, Diego A., Simoes, Luise A. A., Valk, Peter, Fagundes, Evandro M., Tallman, Martin S., Berliner, Nancy, Lucena-Araujo, Antonio R., Cesar Ortiz, Miguel A. Sanz, Douglas R. Silveira, Eduardo M. Rego, Sanz, Miguel A., Ana B. Gloria, Raul C. Ribeiro, Raul A. M. Melo, Elenaide C. Nunes, Evandro M. Fagundes, Pasquini, Ricardo, Rego, Eduardo M., Nunes, Elenaide C., Cleide L. Araujo, Araujo, Cleide L., Thiago M. Bianco, Ganser, Arnold, Schuringa, Jan Jacob, Luisa C. Koury, Ribeiro, Raul C., Weinhauser, Isabel; id_orcid, Ammatuna, Emanuele, Ortiz, Cesar, Bittencourt, Rosane I., Pagnano, Katia, Ricardo Pasquini, Dillon, Richard, Peter Valk, Lowenberg, Bob   +62 more
core   +1 more source

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Haematologica, 2019
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid ...
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng   +13 more
doaj   +1 more source

Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Life on Earth is constantly exposed to electromagnetic fields (EMFs) and the effects induced by EMFs on biological systems have been extensively studied producing different and sometimes contradictory results.
Alfredo Errico Provenzano, Stefano Amatori, Maria Gemma Nasoni, Giuseppe Persico, Sergio Russo, Anna Rita Mastrogiacomo, Alessandro Gambarara, Mirco Fanelli   +7 more
doaj   +1 more source

Molecular Mechanisms of the Antileukemia Activities of Retinoid and Arsenic

Journal of Pharmacological Sciences, 2014
.: Acute promyelocytic leukemia (APL) is characterized by the occurrence of translocations between chromosomes 15 and 17, resulting in generation of a fusion protein of promyelocytic leukemia (PML) and retinoid A receptor (RAR) α. APL cells are unable to
Takeaki Nitto, Kohei Sawaki
doaj   +1 more source