Results 41 to 50 of about 3,564,161 (186)

Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation

Hematology Reports
Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the ...
Sara Frazzetto, Lara Gullo, Gabriele Sapuppo, Manlio Fazio, Cristina Lo Faro, Giuliana Giunta, Ignazio Caravotta, Elisa Mauro, Marina Silvia Parisi, Anna Maria Triolo, Nunziatina Laura Parrinello, Maria Letizia Consoli, Loredana També, Daniela Cambria, Sara Marino, Grazia Scuderi, Francesco Di Raimondo   +16 more
doaj   +1 more source

SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes [PDF]

, 2011
Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance and
Delphine Cuchet-Lourenço, Roger D Everett, Boutell Chris, Roger D. Everett, Sykes Amanda, Murray Jill, Kyle Grant, Jill Murray, Cuchet-Lourenço Delphine, Chris Boutell, Sykes, A., Cuchet-Lourenço, D., Orr Anne, Grant, K., Everett, R.D., Grant Kyle, Boutell, C., Anne Orr, Amanda Sykes, Lukashchuk, V., Murray, J., Vera Lukashchuk, Everett Roger D., Lukashchuk Vera, Orr, A.   +24 more
core   +1 more source

Frontline Management of Acute Promyelocytic Leukemia

, 2023
In the frontline management of acute promyelocytic leukemia (APL), prevention of early deaths and the selection of the optimal frontline induction strategies incorporating arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are the more important ...
Singh, Gill Harinder Harry
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Chidamide acts on the histone deacetylase‐mediated miR‐34a/Bcl‐2 axis to regulate NB4 cell line proliferation and apoptosis

Kaohsiung Journal of Medical Sciences, 2020
Acute promyelocytic leukemia (APL), a biologically and clinically distinct variant of acute myelogenous leukemia, is characterized by the fusion of the N‐terminus of promyelocytic leukemia protein to the C terminus of retinoic acid receptor alpha, mostly
Jie Peng, Shu‐Jun Li, Xiao Fu, Yi Liu, Xie‐Lan Zhao   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Signaling through CD44 affects cell cycle progression and c-Jun expression in acute myeloid leukemia cells [PDF]

, 2004
We present here the first evidence linking CD44 signaling to c-Jun expression and cell cycle progression in myeloid cell line models. CD44 ligation with the anti-CD44 monoclonal antibodies have been shown to induce differentiation and inhibit the ...
Peer Zada, Abdul Ali
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

The PML-RAR alpha transcript in long-term follow-up of acute promyelocytic leukemia patients [PDF]

, 2001
Background and Objectives. Detection of PML-RAR alpha transcripts by RT-PCR is now established as a rapid and sensitive method for diagnosis of acute promyelocytic leukemia (APL), Although the majority of patients in longterm clinical remission are ...
Gameiro, P, Diamond, J, Foroni, L, Silva, AL, Mehta, AB, Prentice, HG, Carrara, P, Vieira, S, Guimaraes, JE, Parreira, A, Hoffbrand, AV, de Sousa, AB   +11 more
core