Results 41 to 50 of about 43,079 (212)
PML protein expression in hematopoietic and acute promyelocytic leukemia cells [PDF]
Blood, 1993 Acute promyelocytic leukemia (APL) is thought to be caused by the t(15,17) translocation that fuses the PML gene to that of the retinoic acid receptor alpha (RAR alpha) and generates a PML/RAR alpha fusion protein. Yet, paradoxically, APL cells are exquisitely sensitive to retinoic acid (RA), as they terminally differentiate upon RA exposure.
M T, Daniel +9 more
openaire +3 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Life on Earth is constantly exposed to electromagnetic fields (EMFs) and the effects induced by EMFs on biological systems have been extensively studied producing different and sometimes contradictory results.
Alfredo Errico Provenzano +7 more
doaj +1 more source
Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein [PDF]
International Journal of Cancer, 2009 AbstractThe promyelocytic leukemia zinc finger (PLZF) protein, a transcriptional repressor, induces cellular resistance to oncogenic transformation by diverse oncoproteins. Two point mutants of PLZF that have lost the antioncogenic activity of the wild‐type protein are oncogenic in chicken embryo fibroblasts; this activity is correlated with ...
Jin, Shi, Peter K, Vogt
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Molecular Mechanisms of the Antileukemia Activities of Retinoid and Arsenic
Journal of Pharmacological Sciences, 2014 .: Acute promyelocytic leukemia (APL) is characterized by the occurrence of translocations between chromosomes 15 and 17, resulting in generation of a fusion protein of promyelocytic leukemia (PML) and retinoid A receptor (RAR) α. APL cells are unable to
Takeaki Nitto, Kohei Sawaki
doaj +1 more source
Dysregulation of Promyelocytic Leukemia (PML) Protein Expression in Preeclamptic Placentae [PDF]
Reproductive Sciences, 2010 Promyelocytic leukemia (PML) protein is a nucleoprotein that can regulate a variety of cellular stress responses. The aim of this study was to determine qualitative and quantitative changes in PML expression in preeclamptic placentae. Immunoblot, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and immunohistochemistry techniques
Jonathan D, Leavenworth +6 more
openaire +2 more sources
Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. [PDF]
, 2013 Important insights into nuclear function would arise if gene loci physically interacting with particular subnuclear domains could be readily identified.
Ahmed, Kashif +4 more
core +2 more sources
RING tetramerization is required for nuclear body biogenesis and PML sumoylation
Nature Communications, 2018 Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear ...
Pengran Wang +11 more
doaj +1 more source
Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. [PDF]
PLoS ONE, 2013 Sirtuins, NAD-dependent protein deacetylases, play important roles in cellular functions such as metabolism and differentiation. Whether sirtuins function in tumorigenesis is still controversial, but sirtuins are aberrantly expressed in tumors, which may
Yoshitaka Sunami +9 more
doaj +1 more source
MORC3, a component of PML nuclear bodies, has a role in restricting herpes simplex virus type 1 and human cytomegalovirus [PDF]
, 2016 We previously reported that MORC3, a protein associated with promyelocytic leukemia nuclear bodies (PML NBs), is a target of HSV-1 ICP0 mediated degradation.
Everett, Roger +2 more
core +1 more source
Journal of Applied Hematology, 2022 Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia, which is highly aggressive, yet the most curable. It is a medical emergency that requires a very high index of suspicion, as delay in the treatment could lead to fatality.
Shipra Verma +3 more
doaj +1 more source