Results 31 to 40 of about 3,564,161 (186)
Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy
Frontiers in Immunology, 2018 The promyelocytic leukemia (PML) protein, also known as TRIM19, functions as a major organizer of PML nuclear bodies (NBs) in most mammalian cells and plays important roles in antiviral activities against both DNA and RNA viruses. In this study, we found
Deyan Chen +8 more
doaj +1 more source
Journal of Applied Hematology, 2022 Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia, which is highly aggressive, yet the most curable. It is a medical emergency that requires a very high index of suspicion, as delay in the treatment could lead to fatality.
Shipra Verma +3 more
doaj +1 more source
Regulation of 92-kD gelatinase release in HL-60 leukemia cells [PDF]
, 1994 Matrix metalloproteinase 9 (MMP-9), also known as 92-kD type IV collagenase/gelatinase, is believed to play a critical role in tumor invasion and metastasis. Here, we report that MMP-9 was constitutively released from the human promyelocytic cell line HL-
Petrides, P. E. +2 more
core +1 more source
Natural Product Communications, 2022 Overexpression of programed death-ligand 1 (PD-L1) is associated with poor prognosis in leukemia. Moreover, antitumor pharmaceuticals have been shown to induce immunoresistance, leading to reduced efficacy.
Shunji Zhang +3 more
doaj +1 more source
Cells, 2021 Calcium ions (Ca2+) play important and diverse roles in the regulation of autophagy, cell death and differentiation. Here, we investigated the impact of Ca2+ in regulating acute promyelocytic leukemia (APL) cell fate in response to the anti-cancer agent ...
Faten Merhi +9 more
doaj +1 more source
Arsenic sulfide promotes apoptosis in retinoid acid resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein. [PDF]
PLoS ONE, 2014 Tetra-arsenic tetra-sulfide (As4S4) is an arsenic compound with anti-tumor activity, especially in acute promyelocytic leukemia (APL) that are resistant to retinoic acid (RA).
Yuwang Tian +10 more
doaj +1 more source
Targeting the MLL complex in acute leukemia [PDF]
, 2014 Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core +1 more source
Virology Journal, 2011 The Epstein-Barr virus (EBV) encoded Latent Membrane Protein 1 (LMP1) has been shown to increase the expression of promyelocytic leukemia protein (PML) and the immunofluorescent intensity of promyelocytic leukemia nuclear bodies (PML NBs).
Flemington Erik K +5 more
doaj +1 more source
Targeting pseudokinase TRIB3 brings about a new therapeutic option for acute promyelocytic leukemia
Molecular & Cellular Oncology, 2017 Pseudokinase tribbles (Trib) family, Trib1 and Trib2, but not Trib3, act as oncogene to drive acute leukemia by destabilizing the myeloid transcription factor CCAAT/enhancer-binding protein α (C/EBPα) and inhibiting myeloid differentiation.
Ke Li, Feng Wang, Zhuo-Wei Hu
doaj +1 more source
Differential roles of PML isoforms
Frontiers in Oncology, 2013 The tumor suppressor promyelocytic leukemia protein (PML) is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia (APL).
Sébastien eNisole +7 more
doaj +1 more source