Results 31 to 40 of about 120,872 (251)
Control of hepatic gluconeogenesis by the promyelocytic leukemia zinc finger protein. [PDF]
Molecular Endocrinology, 2014 The promyelocytic leukemia zinc finger (PLZF) protein is involved in major biological processes including energy metabolism, although its role remains unknown. In this study, we demonstrated that hepatic PLZF expression was induced in fasted or diabetic mice.
Siyu Chen +5 more
semanticscholar +3 more sources
Biomolecular Condensates in Myeloid Leukemia: What Do They Tell Us?
HemaSphere, 2023 Recent studies have suggested that several oncogenic and tumor-suppressive proteins carry out their functions in the context of specific membrane-less cellular compartments.
Zivojin Jevtic +3 more
doaj +1 more source
Frontiers in Oncology, 2023 Acute myeloid leukemia (AML) is a malignant disease of myeloid hematopoietic stem/progenitor cells characterized by the abnormal proliferation of primitive and naive random cells in the bone marrow and peripheral blood. Acute promyelocytic leukemia (APL)
Chengjun Hu +9 more
doaj +1 more source
Effects of Promyelocytic Leukemia Protein on Virus-Host Balance [PDF]
Journal of Virology, 2002 ABSTRACTThe cellular promyelocytic leukemia protein (PML) associates with the proteins of several viruses and in some cases reduces viral propagation in cell culture. To examine the role of PML in vivo, we compared immune responses and virus loads of PML-deficient and control mice infected with lymphocytic choriomeningitis virus (LCMV) and vesicular ...
Bonilla, Weldy V. +8 more
openaire +4 more sources
Haematologica, 2011 Impairment of CCAAT Enhancer Binding Protein alpha (CEBPA) function is a common finding in acute myeloid leukemia; nevertheless, its relevance for acute promyelocytic leukemia pathogenesis is unclear.
Bárbara Amélia Santana-Lemos +7 more
doaj +1 more source
The treatment of acute promyelocytic leukemia in 2023: Paradigm, advances, and future directions
Frontiers in Oncology, 2023 The transformation of acute promyelocytic leukemia (APL) from an often fatal to highly curable cancer with long-term survival exceeding 90% is one of the greatest and most inspiring successes in oncology. A deeper understanding of the pathogenesis of APL
S. Iyer +3 more
semanticscholar +1 more source
PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]
, 2014 Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J. +7 more
core +1 more source
PML nuclear body biogenesis and oligomerization-driven leukemogenesis
Blood Science, 2020 . PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm.
Yuwen Li, Xiaodan Ma, Guoyu Meng
doaj +1 more source
Haematologica, 2019 Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu +9 more
doaj +1 more source
Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. [PDF]
, 2011 The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression.
Baiker Armin +28 more
core +1 more source