Results 31 to 40 of about 43,079 (212)

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
doaj   +1 more source

Severe acute axonal neuropathy following treatment with arsenic trioxide for acute promyelocytic leukemia: a case report [PDF]

, 2016
Peripheral neuropathy is a common complication of arsenic toxicity. Symptoms are usually mild and reversible following discontinuation of treatment. A more severe chronic sensorimotor polyneuropathy characterized by distal axonal-loss neuropathy can be ...
Kuhn, Marcus, Nabergoj, Mithia, Sammartin, Kety, Vianello, Fabrizio   +3 more
core   +3 more sources

Promyelocytic Leukemia-Nuclear Body Proteins: Herpesvirus Enemies, Accomplices, or Both? [PDF]

Future Virology, 2008
The promyelocytic leukemia (PML) protein gathers other cellular proteins, such as Daxx and Sp100, to form subnuclear structures termed PML-nuclear bodies (PML-NBs) or ND10 domains. Many infecting viral genomes localize to PML-NBs, leading to speculation that these structures may represent the most efficient subnuclear location for viral replication ...
Ryan T, Saffert, Robert F, Kalejta
openaire   +2 more sources

B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

Nature Communications, 2019
Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show
Yuwen Li, Xiaodan Ma, Zhiming Chen, Haiyan Wu, Pengran Wang, Wenyu Wu, Nuo Cheng, Longhui Zeng, Hao Zhang, Xun Cai, Sai-Juan Chen, Zhu Chen, Guoyu Meng   +12 more
doaj   +1 more source

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Blood Advances, 2018
: The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that Hhex maintains leukemia stem cell self-renewal by enabling ...
Jacob T. Jackson, Ashley P. Ng, Benjamin J. Shields, Sue Haupt, Ygal Haupt, Matthew P. McCormack   +5 more
doaj   +1 more source

A role for cytoplasmic PML in cellular resistance to viral infection. [PDF]

PLoS ONE, 2008
PML gene was discovered as a fusion partner with retinoic acid receptor (RAR) alpha in the t(15:17) chromosomal translocation associated with acute promyelocytic leukemia (APL).
Beth A McNally, Joanne Trgovcich, Gerd G Maul, Yang Liu, Pan Zheng   +4 more
doaj   +1 more source

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. [PDF]

, 1984
The human-derived promyelocytic leukemia cell line, HL-60, is known to differentiate into mature myeloid cells in the presence of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).
Donaldson, CA, Haussler, MR, Haussler, MR, Koeffler, HP, Mangelsdorf, DJ, Pike, JW   +5 more
core   +1 more source

Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells [PDF]

, 2019
In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line.
Baiocco, P., Boffi, A., Bonamore, A., Fazi, F., Macone, A., Masciarelli, S., Palombarini, Federica, Quaglio, D., Trabuco, M. C.   +8 more
core   +2 more sources

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Haematologica, 2019
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid ...
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng   +13 more
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source