Results 51 to 60 of about 120,872 (251)
Association of caspase-2 with the promyelocytic leukemia protein nuclear bodies [PDF]
Cancer Biology & Therapy, 2005 Apoptotic cell death is executed by a family of cysteine proteases known as caspases. Synthesized as inactive precursors, caspases become activated sequentially in cascades. Activation of apical or initiator caspases in these cascades occurs in macromolecular complexes located in various compartments. One such complex is the plasma membrane-bound death-
Jun, Tang, Wensheng, Xie, Xiaolu, Yang
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Free Radical Biology & Medicine, 2017 Respiratory syncytial virus (RSV) is the most important cause of viral acute respiratory tract infections and hospitalizations in children, for which no vaccine or specific treatments are available.
Narayana Komaravelli +3 more
semanticscholar +1 more source
RING tetramerization is required for nuclear body biogenesis and PML sumoylation
Nature Communications, 2018 Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear ...
Pengran Wang +11 more
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Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. [PDF]
PLoS ONE, 2013 Sirtuins, NAD-dependent protein deacetylases, play important roles in cellular functions such as metabolism and differentiation. Whether sirtuins function in tumorigenesis is still controversial, but sirtuins are aberrantly expressed in tumors, which may
Yoshitaka Sunami +9 more
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PLoS Pathogens, 2015 Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such as cell proliferation, apoptosis, gene regulation, and DNA damage response. PML also acts as a
Young-Eui Kim, Jin-Hyun Ahn
semanticscholar +1 more source
Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein [PDF]
International Journal of Cancer, 2009 AbstractThe promyelocytic leukemia zinc finger (PLZF) protein, a transcriptional repressor, induces cellular resistance to oncogenic transformation by diverse oncoproteins. Two point mutants of PLZF that have lost the antioncogenic activity of the wild‐type protein are oncogenic in chicken embryo fibroblasts; this activity is correlated with ...
Jin, Shi, Peter K, Vogt
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Journal of Applied Hematology, 2022 Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia, which is highly aggressive, yet the most curable. It is a medical emergency that requires a very high index of suspicion, as delay in the treatment could lead to fatality.
Shipra Verma +3 more
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Molecular and Cellular Biology, 2015 To trigger type I interferon (IFN) responses, pattern recognition receptors activate signaling cascades that lead to transcription of IFN and IFN-stimulated genes (ISGs).
Yixiang Chen +3 more
semanticscholar +1 more source
Dysregulation of Promyelocytic Leukemia (PML) Protein Expression in Preeclamptic Placentae [PDF]
Reproductive Sciences, 2010 Promyelocytic leukemia (PML) protein is a nucleoprotein that can regulate a variety of cellular stress responses. The aim of this study was to determine qualitative and quantitative changes in PML expression in preeclamptic placentae. Immunoblot, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and immunohistochemistry techniques
Jonathan D, Leavenworth +6 more
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Targeting the MLL complex in acute leukemia [PDF]
, 2014 Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core +1 more source