Results 61 to 70 of about 120,872 (251)

Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy

Frontiers in Immunology, 2018
The promyelocytic leukemia (PML) protein, also known as TRIM19, functions as a major organizer of PML nuclear bodies (NBs) in most mammalian cells and plays important roles in antiviral activities against both DNA and RNA viruses. In this study, we found
Deyan Chen, Chunhong Feng, Xiaoyan Tian, Nan Zheng, Nan Zheng, Nan Zheng, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu   +8 more
doaj   +1 more source

Brusatol From Suppresses Arsenic Trioxide-Induced PD-L1 Upregulation Through Inhibition of NRF2 in Leukemia Cells

Natural Product Communications, 2022
Overexpression of programed death-ligand 1 (PD-L1) is associated with poor prognosis in leukemia. Moreover, antitumor pharmaceuticals have been shown to induce immunoresistance, leading to reduced efficacy.
Shunji Zhang, Meijuan Sui, Zhuo Zhang, Yanhua Su   +3 more
doaj   +1 more source

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid

Cells, 2021
Calcium ions (Ca2+) play important and diverse roles in the regulation of autophagy, cell death and differentiation. Here, we investigated the impact of Ca2+ in regulating acute promyelocytic leukemia (APL) cell fate in response to the anti-cancer agent ...
Faten Merhi, Karla Alvarez-Valadez, Jenifer Trepiana, Claire Lescoat, Alexis Groppi, Jean-William Dupuy, Pierre Soubeyran, Guido Kroemer, Pierre Vacher, Mojgan Djavaheri-Mergny   +9 more
doaj   +1 more source

Expression of the promyelocytic leukemia protein without the nuclear localization signal as a novel diagnostic marker for acute promyelocytic leukemia

Oncology Reports, 2017
Promyelocytic leukemia-retinoic acid receptor α (PML-RARα) is a fusion protein generated by the t(15;17)(q22;q12) translocation associated with acute promyelocytic leukemia (APL). PML-RARα is cleaved by neutrophil elastase, an early myeloid-specific serine protease, leading to translocation of the nuclear localization signal (NLS) of the PML protein to
Ting, Xu, Xiao-Qun, Yang, Kai-Ling, Jiang, Hui, Wang, Peng-Peng, Ma, Liang, Zhong, Bei-Zhong, Liu   +6 more
openaire   +3 more sources

A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma [PDF]

Clinical Cancer Research, 2016
Abstract Purpose: Neuroblastoma is a childhood malignancy originating from the sympathetic nervous system with a complex biology, prone to metastasize and relapse. High-risk, metastatic cases are explained in part by amplification or mutation of oncogenes, such as MYCN and ALK, and loss of tumor suppressor genes in chromosome band 1p.
Dvorkina, M, Nieddu, V, Chakelam, S, Pezzolo, A, Cantilena, S, Leite, AP, Chayka, O, Regad, T, Pistorio, A, Sementa, AR, Virasami, A, Barton, J, Montano, X, Lechertier, T, Brindle, N, Morgenstern, D, Le Bras, M, Burns, A, Saunders, N, Hodivala-Dilke, K, Bagella, L, de The, H, Anderson, J, Sebire, N, Pistoia, V, Sala, A, Salomoni, P   +26 more
openaire   +6 more sources

Arsenic sulfide promotes apoptosis in retinoid acid resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein. [PDF]

PLoS ONE, 2014
Tetra-arsenic tetra-sulfide (As4S4) is an arsenic compound with anti-tumor activity, especially in acute promyelocytic leukemia (APL) that are resistant to retinoic acid (RA).
Yuwang Tian, Yanfeng Liu, Pengcheng He, Feng Liu, Naicen Zhou, Xiaoyan Cheng, Lili Shi, Huachao Zhu, Jing Zhao, Yuan Wang, Mei Zhang   +10 more
doaj   +1 more source

SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes [PDF]

, 2011
Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance and
Delphine Cuchet-Lourenço, Roger D Everett, Boutell Chris, Roger D. Everett, Sykes Amanda, Murray Jill, Kyle Grant, Jill Murray, Cuchet-Lourenço Delphine, Chris Boutell, Sykes, A., Cuchet-Lourenço, D., Orr Anne, Grant, K., Everett, R.D., Grant Kyle, Boutell, C., Anne Orr, Amanda Sykes, Lukashchuk, V., Murray, J., Vera Lukashchuk, Everett Roger D., Lukashchuk Vera, Orr, A.   +24 more
core   +1 more source

Targeting pseudokinase TRIB3 brings about a new therapeutic option for acute promyelocytic leukemia

Molecular & Cellular Oncology, 2017
Pseudokinase tribbles (Trib) family, Trib1 and Trib2, but not Trib3, act as oncogene to drive acute leukemia by destabilizing the myeloid transcription factor CCAAT/enhancer-binding protein α (C/EBPα) and inhibiting myeloid differentiation.
Ke Li, Feng Wang, Zhuo-Wei Hu
doaj   +1 more source

Tumor suppressor function of Gata2 in Acute Promyelocytic Leukemia.

Blood, 2021
Most patients with acute promyelocytic leukemia (APL) can be cured with combined All Trans Retinoic Acid (ATRA) and Arsenic Trioxide therapy, which induce the destruction of PML-RARA, the initiating fusion protein for this disease1.
Casey D. S. Katerndahl, Olivia R S Rogers, Ryan B Day, Mi Cai, Timothy P. C. Rooney, Nichole M. Helton, Mieke Hoock, S. M. Ramakrishnan, S. Srivatsan, L. Wartman, Christopher A. Miller, T. Ley   +11 more
semanticscholar   +1 more source

Ataxin-1 fusion partners alter polyQ lethality and aggregation [PDF]

, 2007
Intranuclear inclusion bodies (IBs) are the histopathologic markers of multiple protein folding diseases. IB formation has been extensively studied using fluorescent fusion products of pathogenic polyglutamine (polyQ) expressing proteins.
Rich, T., Varadaraj, A., Archana Varadaraj, Varadaraj Archana, Tina Rich, Rich Tina   +5 more
core   +1 more source