Results 61 to 70 of about 43,079 (212)

Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation

Hematology Reports
Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the ...
Sara Frazzetto, Lara Gullo, Gabriele Sapuppo, Manlio Fazio, Cristina Lo Faro, Giuliana Giunta, Ignazio Caravotta, Elisa Mauro, Marina Silvia Parisi, Anna Maria Triolo, Nunziatina Laura Parrinello, Maria Letizia Consoli, Loredana També, Daniela Cambria, Sara Marino, Grazia Scuderi, Francesco Di Raimondo   +16 more
doaj   +1 more source

Differential roles of PML isoforms

Frontiers in Oncology, 2013
The tumor suppressor promyelocytic leukemia protein (PML) is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia (APL).
Sébastien eNisole, Sébastien eNisole, Mohamed Ali eMaroui, Mohamed Ali eMaroui, Xavier eMascle, Muriel eAubry, Mounira K Chelbi-Alix, Mounira K Chelbi-Alix   +7 more
doaj   +1 more source

Cellular promyelocytic leukemia protein is an important dengue virus restriction factor. [PDF]

PLoS One, 2015
La défense antivirale intrinsèque est basée sur des facteurs de restriction cellulaire qui sont exprimés de manière constitutive et, par conséquent, actifs avant même qu'un agent pathogène n'entre dans la cellule. Les corps nucléaires (NB) de la leucémie promyélocytaire (LEMP) sont des foyers nucléaires discrets qui contiennent plusieurs protéines ...
Giovannoni F, Damonte EB, García CC.
europepmc   +6 more sources

The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA [PDF]

, 2016
Alterations in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells.
Bozzoni, Irene, Fatica, Alessandro, Fazi, Francesco, Iosue', Ilaria, Larivera, Simone, Legnini, Ivano, Mangiavacchi, Arianna, Masciarelli, Silvia, Sorci, Melissa   +8 more
core   +2 more sources

Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

Leukemia Research, 2013
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA.
Topić, Iva, Ikić, Marina, Ivčević, Sanja, Kovačić, Nataša, Marušić, Ana, Kušec, Rajko, Grčević, Danka   +6 more
openaire   +4 more sources

Association of caspase-2 with the promyelocytic leukemia protein nuclear bodies [PDF]

Cancer Biology & Therapy, 2005
Apoptotic cell death is executed by a family of cysteine proteases known as caspases. Synthesized as inactive precursors, caspases become activated sequentially in cascades. Activation of apical or initiator caspases in these cascades occurs in macromolecular complexes located in various compartments. One such complex is the plasma membrane-bound death-
Jun, Tang, Wensheng, Xie, Xiaolu, Yang
openaire   +2 more sources

Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]

, 2019
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I, Hofmann, Inga, Kong, Guangyao, Letson, Christopher, Liu, Yangang, Loh, Mignon, Padron, Eric, Pear, Warren S, Qian, Shuiming, Rajagopalan, Adhithi, Ranheim, Erik A, Stieglitz, Elliot, Wen, Zhi, Yang, David, You, Xiaona, Zhang, Jing, Zhang, Jingfang, Zhang, Xinmin, Zhong, Xuehua, Zhou, Lan, Zhou, Yun   +20 more
core   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Chidamide acts on the histone deacetylase‐mediated miR‐34a/Bcl‐2 axis to regulate NB4 cell line proliferation and apoptosis

Kaohsiung Journal of Medical Sciences, 2020
Acute promyelocytic leukemia (APL), a biologically and clinically distinct variant of acute myelogenous leukemia, is characterized by the fusion of the N‐terminus of promyelocytic leukemia protein to the C terminus of retinoic acid receptor alpha, mostly
Jie Peng, Shu‐Jun Li, Xiao Fu, Yi Liu, Xie‐Lan Zhao   +4 more
doaj   +1 more source

Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]

, 2009
Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo, Beech, Bernardi, Bernardi, Borden, Bourhis, Callaghan, Carvalho, Condemine, Condemine, Dalessio, Doucas, E. Emmott, Evans, Everett, Everett, Everett, Fagioli, Fagioli, Hoppe, Ishov, Janderova-Rossmeislova, Jensen, K. N. Leppard, Kalderon, Kelly, Liu, M. S. Cortese, Mohan, Nevels, Peng, Romero, Salomoni, Scaglioni, Shen, Sternsdorf, Stracker, T. Rich   +37 more
core   +1 more source