Results 71 to 80 of about 43,079 (212)

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Promyelocytic Leukemia Protein 4 Induces Apoptosis by Inhibition of Survivin Expression [PDF]

Journal of Biological Chemistry, 2004
The promyelocytic leukemia protein (PML) plays an essential role in multiple pathways of apoptosis. Our previous study showed that PML enhances tumor necrosis factor-induced apoptosis by inhibiting the NFkappaB survival pathway. To continue exploring the mechanism of PML-induced apoptosis, we performed a DNA microarray screening of PML target genes ...
Z. Xu, R. Zhao, T. Ding, T. T. Tran, W. Zhang, PANDOLFI DE RINALDIS, Pier Paolo, K. Chang   +6 more
openaire   +3 more sources

Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells [PDF]

, 2016
open7siBesides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions.
Celeghin, Andrea, De Rossi, Anita, Dolcetti, Riccardo, Freguja, Riccardo, Giunco, Silvia, Nalio, Silvia, Zangrossi, Manuela   +6 more
core   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies [PDF]

International Journal of Biological Sciences, 2009
The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These cellular activities often rely on the localization of PML to unique subnuclear structures known as PML nuclear bodies (NBs).
Erin L, Reineke, Hung-Ying, Kao
openaire   +2 more sources

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Control of Hepatic Gluconeogenesis by the Promyelocytic Leukemia Zinc Finger Protein [PDF]

Molecular Endocrinology, 2014
The promyelocytic leukemia zinc finger (PLZF) protein is involved in major biological processes including energy metabolism, although its role remains unknown. In this study, we demonstrated that hepatic PLZF expression was induced in fasted or diabetic mice.
Siyu, Chen, Jinchun, Qian, Xiaoli, Shi, Tingting, Gao, Tingming, Liang, Chang, Liu   +5 more
openaire   +2 more sources

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]

, 2014
Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Beech, Bernardi, Boisvert, Brand, Condemine, Condemine, Cuchet, Cuchet-Lourenço, de Thé, Fogal, Geng, Geoffroy, Hattersley, Hu, Ishov, Jeanne, Jensen, Jul-Larsen, Kamitani, Koken, Lallemand-Breitenbach, Lallemand-Breitenbach, Lallemand-Breitenbach, Lang, Lång, Maroui, Mathews, Negorev, Powell, Tatham, Weidtkamp-Peters, Weisshaar, Xu, Yu, Zhu   +34 more
core   +4 more sources

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source