Results 91 to 100 of about 3,564,161 (186)

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

Rethinking Drug Resistance in Acute Promyelocytic Leukemia: The Regulated Cell Death Network as an Integrative Framework

Biomolecules
Drug resistance in acute promyelocytic leukemia (APL) remains clinically challenging despite the success of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) therapy.
Shiyu Lin, Biaohan Qin, Zhexi Ye, Jiaqi Qing, Hui Zhen, Sennan Yang, Xin Jiang, Yiwen Fan, Lemei Zhu, Juan Liu   +9 more
doaj   +1 more source

New strategies to direct therapeutic targeting of PML to treat cancers

Frontiers in Oncology, 2013
The tumor suppressor function of the promyelocytic leukemia (PML) protein was first identified as a result of its dysregulation in acute promyelocytic leukemia (APL), however, its importance is now emerging far beyond hematological neoplasms, to an ...
Kamil eWolyniec, Kamil eWolyniec, Dennis Anthony Carney, Dennis Anthony Carney, Dennis Anthony Carney, Sue eHaupt, Sue eHaupt, Ygal eHaupt, Ygal eHaupt, Ygal eHaupt, Ygal eHaupt   +10 more
doaj   +1 more source

Prognostic Significance of Secondary‐Type Mutations in NPM1‐Mutated Acute Myeloid Leukemia

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML), and NPM1‐mutated AML is generally associated with a favorable prognosis. However, substantial prognostic heterogeneity exists within this population. The prognostic significance of secondary‐type mutations (STMs) in NPM1‐mutated AML remains controversial.
Kun Yang, Hongmei Luo, Bing Xiang, Yang Dai, Yuping Gong, Jie Huang, Jianjun Li, Yongqian Jia, Yong Guo, Yuhuan Zheng, Hongbing Ma   +10 more
wiley   +1 more source

Management of Relapsed Acute Promyelocytic Leukemia and the Role of Hematopoietic Stem Cell Transplantation

, 2023
This chapter addresses one of the most controversial issues in the management of acute promyelocytic leukemia (APL) which is the optimal management of relapsed APL following second remission and role of hematopoietic stem cell transplantation in APL ...
Singh, Gill Harinder Harry
core   +1 more source

Identification and functional characterization of the novel MAR-binding protein, SATB2 [PDF]

, 2004
The regulation of gene expression is governed in large part by transcription factors that bind to enhancers and promoters. The functions of transcription factors involve both the modulation of chromatin accessibility via the recruitment of histone ...
Dobreva, Gergana
core   +1 more source

Crosstalk between p53 modifiers at PML bodies

Molecular & Cellular Oncology, 2018
Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj   +1 more source

Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells. [PDF]

Virol J, 2023
Chen Z, Liu H, Zhu J, Duan X, Wang H, Li X, Zhou X, Zhao A, Yang S.   +8 more
europepmc   +1 more source

Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy

Cancer Medicine, Volume 15, Issue 9, September 2026.
Cancer stem cell quiescence is a regulated, reversible survival mechanism, preserving stemness and promoting therapy resistance through intrinsic programs and niche signals. Targeting these pathways holds promise for eradicating quiescent CSCs and preventing recurrence.
Yasin Ahmadi, Trefa M. Abdullah, Sakhavat Abolhasani, Amin Jalizi   +3 more
wiley   +1 more source

The role of PML proteins in adenovirus type 5 infection and the type I interferon response [PDF]

Promyelocytic leukaemia (PML) proteins consist of a collection of related isoforms that are the nucleating components of sub-nuclear structures termed PML nuclear bodies (PML NBs). Numerous functions are attributed to PML and PML NBs, including a role
Wright, Jordan
core