Results 101 to 110 of about 120,872 (251)

Leucemia promielocítica aguda: avaliação retrospectiva dos casos diagnosticados e tratados pelo serviço de hematologia do hospital universitário da Universidade Federal de Santa Catarina entre 2001 a 2013 [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.A leucemia promielocítica aguda (LPA) é um subtipo distinto de leucemia mieloide aguda (LMA ...
Durigon, Giovanna Steffenello
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PRAM-1 Is a Novel Adaptor Protein Regulated by Retinoic Acid (RA) and Promyelocytic Leukemia (PML)-RA Receptor α in Acute Promyelocytic Leukemia Cells

, 2001
International audienceThe t(15;17) translocation, found in 95% of acute promyelocytic leukemia, encodes a promyelocytic leukemia (PML)-retinoic acid receptor alpha (RARalpha) fusion protein.
Lutz, Pierre, Joanne Kamens, Di Gioia, Yolande, Steve Eliason, Kamens, Joanne, Yvon E. Cayre, Singer, Andrew, Koretzky, Gary, Erik J. Peterson, Florence Cavé-Riant, Sally Dmowski, Moog-Lutz, Christel, Yolande Di Gioia, Pierre G. Lutz, Gary Koretzky, Christel Moog-Lutz, Cayre, Yvon, Andrew Singer, Peterson, Erik, Dmowski, Sally, Eliason, Steve, Cavé-Riant, Florence   +21 more
core   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

Signaling through CD44 affects cell cycle progression and c-Jun expression in acute myeloid leukemia cells [PDF]

, 2004
We present here the first evidence linking CD44 signaling to c-Jun expression and cell cycle progression in myeloid cell line models. CD44 ligation with the anti-CD44 monoclonal antibodies have been shown to induce differentiation and inhibit the ...
Abdul Ali Peer Zada, Peer Zada, Abdul Ali   +1 more
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Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source

Microtubule-associated protein 1 light chain 3 interacts with and contributes to growth inhibiting effect of PML.

PLoS ONE, 2014
Previously we reported that the expression of promyelocytic leukemia (PML)-retinoic acid receptor alpha (RARα) fusion gene, which is caused by specific translocation (15;17) in acute promyelocytic leukemia, can enhance constitutive autophagic activity in
Wei He, Chuan-Xi Hu, Jia-Kai Hou, Li Fan, Yi-Wei Xu, Man-Hua Liu, Shu-Yang Yan, Guo-Qiang Chen, Ying Huang   +8 more
doaj   +1 more source

Oral Mucositis in Oncopediatric Patients: MTX and MMP‐1, MMP‐8, MMP‐13 Gene Polymorphisms

Oral Diseases, EarlyView.
ABSTRACT Background This study investigates the association between single‐nucleotide polymorphisms (SNPs) in the MMP‐1, MMP‐8, and MMP‐13 genes and the risk of oral mucositis development in paediatric patients with leukaemia and lymphoma who are undergoing methotrexate (MTX) treatment.
Nicole Januário Ribeiro, Larissa Helena Tissi, Mateus Tissot Escobar, Ana Maria Gondim Valença, Ricardo Lehtonen Rodrigues Souza, Naila Francis Paulo de Oliveira, Maria Cristina Leme Godoy Santos   +6 more
wiley   +1 more source

Arsenic Mediated Disruption of Promyelocytic Leukemia Protein Nuclear Bodies Induces Ganciclovir Susceptibility in Epstein-Barr Positive Epithelial Cells

Virology, 2011
Promyelocytic leukemia protein nuclear bodies (PML NBs) have been implicated in host immune response to viral infection. PML NBs are targeted for degradation during reactivation of herpes viruses, suggesting that disruption of PML NB function supports ...
Mark D. Sides, Gregory J. Block, B. Shan, Kyle C. Esteves, Zhen Lin, E. Flemington, J. Lasky   +6 more
semanticscholar   +1 more source

Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells [PDF]

Leukemia Research, 2013
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA.
Topić, Iva, Ikić, Marina, Ivčević, Sanja, Kovačić, Nataša, Marušić, Ana, Kušec, Rajko, Grčević, Danka   +6 more
openaire   +4 more sources

Proteomics of Acute Myeloid Leukemia [PDF]

, 2007
Acute Myeloid Leukemia (AML) is characterized by specific cytogenetic aberrations that are strong determinants of prognostic outcome and therapeutic response.
Yaseen, Mumtaz
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