Results 81 to 90 of about 120,872 (251)

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Ablation of Promyelocytic Leukemia Protein (PML) Re-patterns Energy Balance and Protects Mice from Obesity Induced by a Western Diet*

Journal of Biological Chemistry, 2013
Background: The role of PML in metabolism remains largely unexplored. Results: PML ablation re-patterns energy balance in mice by promoting fatty acid metabolism.
Xiwen Cheng, Shuang Guo, Yu Liu, Hao Chu, Parvin Hakimi, N. Berger, R. Hanson, H. Kao   +7 more
semanticscholar   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein [PDF]

Oncogene, 1998
The growth and transformation suppressor function of promyelocytic leukemia (PML) protein are disrupted in acute promyelocytic leukemia (APL) as a result of its fusion to the RARalpha gene by t(15;17) translocation. There is significant sequence homology between the dimerization domain of PML and the Fos family of proteins, which imply that PML may be ...
S, Vallian, J A, Gäken, E B, Gingold, T, Kouzarides, K S, Chang, F, Farzaneh   +5 more
openaire   +2 more sources

PML: Regulation and multifaceted function beyond tumor suppression

Cell & Bioscience, 2018
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML–RARα and RARα–PML fusion proteins ...
Kuo-Sheng Hsu, Hung-Ying Kao
doaj   +1 more source

Autoantibodies to speckled protein family in primary biliary cholangitis

Allergy, Asthma & Clinical Immunology, 2021
The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients.
Alessandro Granito, Luigi Muratori, Francesco Tovoli, Paolo Muratori   +3 more
doaj   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Contribution of the C-terminal Regions of Promyelocytic Leukemia Protein (PML) Isoforms II and V to PML Nuclear Body Formation*

Journal of Biological Chemistry, 2012
Background: Multiple promyelocytic leukemia protein (PML) isoforms co-exist in PML nuclear bodies (NBs). Results: The C-terminal regions of PML isoforms II and V can form nuclear bodies and target to PML-NBs in the absence of the N terminus.
Yunyun Geng, S. Monajembashi, Anwen Shao, D. Cui, Weiyong He, Zhongzhou Chen, P. Hemmerich, Jun Tang   +7 more
semanticscholar   +1 more source

Promyelocytic Leukemia-Nuclear Body Proteins: Herpesvirus Enemies, Accomplices, or Both? [PDF]

Future Virology, 2008
The promyelocytic leukemia (PML) protein gathers other cellular proteins, such as Daxx and Sp100, to form subnuclear structures termed PML-nuclear bodies (PML-NBs) or ND10 domains. Many infecting viral genomes localize to PML-NBs, leading to speculation that these structures may represent the most efficient subnuclear location for viral replication ...
Ryan T, Saffert, Robert F, Kalejta
openaire   +2 more sources

Análise dos polimorfismos dos transcritos da translocação T(15;17)(Q22;Q21) na leucemia promielocítica aguda [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.As leucemias agudas (LAs) constituem um grupo de neoplasias malignas caracterizado pela proliferação descontrolada de células hematopoiéticas na medula óssea
Silveira, Amanda da Silva
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