Results 81 to 90 of about 43,079 (212)

PML: Regulation and multifaceted function beyond tumor suppression

Cell & Bioscience, 2018
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML–RARα and RARα–PML fusion proteins ...
Kuo-Sheng Hsu, Hung-Ying Kao
doaj   +1 more source

Autoantibodies to speckled protein family in primary biliary cholangitis

Allergy, Asthma & Clinical Immunology, 2021
The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients.
Alessandro Granito, Luigi Muratori, Francesco Tovoli, Paolo Muratori   +3 more
doaj   +1 more source

Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells [PDF]

, 2004
Recent studies suggest that components of the prosurvival signal transduction pathways involving the Ras-mitogen-activated protein kinase ( MAPK) can confer an aggressive, apoptosis-resistant phenotype to leukemia cells.
Bonati, A, Lo Coco, F, Lunghi, P, Pelicci, P, Tabilio, A   +4 more
core   +2 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome [PDF]

Molecular Cancer Therapeutics, 2008
Abstract The HMGA2 architectural protein functions in a variety of cellular processes, such as cell growth, transcription regulation, neoplastic transformation, and progression. Up-regulation of HMGA2 protein is observed in many tumors and is associated with advanced cancers with poor prognoses. Although the expression and biochemical
Xuefei, Cao, Carlos, Clavijo, Xu, Li, H Helen, Lin, Yuan, Chen, Hsiu-Ming, Shih, David K, Ann   +6 more
openaire   +2 more sources

Validation of a Multiparametric, Automated, Macroarray‐Based Assay for the Detection of Autoantibodies in Autoimmune Liver Disease

Journal of Clinical Laboratory Analysis, EarlyView.
The assay exploited a multiparametric and fully automated device applied to CHORUS EVO to validate that the CHORUS Macroarray Liver Diseases kit is a novel procedure for detecting autoantibodies of AIH and PBC. The assay resulted as linear, accurate, sensitive, specific, and able to distinguish between PBC and AIH.
Luigi Raganelli, Tommaso Bandini, Matilde Ilacqua, Helena Cerutti, Alessandra Cartocci, Giulia Tesi, Andrea Ianniello, Thomas Massari, Mirko Berretti, Roberto Centini, Michele Norelli, Alessandra Brogi, Giampaola Pesce, Danilo Villalta, Brunetta Porcelli   +14 more
wiley   +1 more source

Genetic Expression Screening of Arsenic Trioxide-Induced Cytotoxicity in KG-1a Cells Based on Bioinformatics Technology

Frontiers in Genetics, 2021
Acute myeloid leukemia (AML) is a malignant tumor of the hematopoietic system, and leukemia stem cells are responsible for AML chemoresistance and relapse.
Yahui Li, Yingjie Feng, Xiaohui Si, Chenjin Zhao, Fanping Wang, Xinqing Niu   +5 more
doaj   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

Expression of the promyelocytic leukemia protein without the nuclear localization signal as a novel diagnostic marker for acute promyelocytic leukemia

Oncology Reports, 2017
Promyelocytic leukemia-retinoic acid receptor α (PML-RARα) is a fusion protein generated by the t(15;17)(q22;q12) translocation associated with acute promyelocytic leukemia (APL). PML-RARα is cleaved by neutrophil elastase, an early myeloid-specific serine protease, leading to translocation of the nuclear localization signal (NLS) of the PML protein to
Ting, Xu, Xiao-Qun, Yang, Kai-Ling, Jiang, Hui, Wang, Peng-Peng, Ma, Liang, Zhong, Bei-Zhong, Liu   +6 more
openaire   +3 more sources

Sumoylation of the Tumor Suppressor Promyelocytic Leukemia Protein Regulates Arsenic Trioxide-Induced Collagen Synthesis in Osteoblasts

Cellular Physiology and Biochemistry, 2015
Background/Aims: Promyelocytic leukemia (PML) protein is a tumor suppressor that fuses with retinoic acid receptor-α (PML-RARα) to contribute to the initiation of acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) upregulates expression of TGF-β1,
Wen-Xiao Xu, Sheng-Zhi Liu, Di Wu, Guo-Fen Qiao, Jinglong Yan   +4 more
doaj   +1 more source