Results 81 to 90 of about 3,564,161 (186)

Elucidating the role of the tumor suppressor Protein Phoshatase 2A in Chronic Myeloid Leukemia. [PDF]

, 2010
Protein phosphatase-2A (PP2A) is one of the major cellular serine-threonine phosphatases and is involved in the regulation of cell homeostasis through the negative regulation of signaling pathways initiated by protein kinases.
Neviani, Paolo
core  

PML Nuclear bodies: the cancer connection and beyond

Nucleus
Promyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners.
Majdouline Abou-Ghali, Valérie Lallemand-Breitenbach   +1 more
doaj   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Acute Promyelocytic Leukemia

, 2020
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia ...
Maël Heiblig, Xavier Thomas
core   +1 more source

Proteomic Identification of the MYST Domain Histone Acetyltransferase TIP60 as a Coactivator of the Myeloid Transcription Factor C/EBPα [PDF]

, 2007
The transcription factor C/EBPα is a key player in granulopoiesis and leukemogenesis. In the present study, we sought to identify C/EBPα interacting proteins.
Bararia, Deepak
core   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, Volume 13, Issue 52, 18 September 2026.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA

American Journal of Hematology, Volume 101, Issue 9, Page 2246-2257, September 2026.
ABSTRACT Frameshift mutations in exon 12 of nucleophosmin 1 (NPM1 mut) are among the most common mutations in acute myeloid leukemia (AML) and have historically been considered favorable‐risk in the absence of FLT3‐ITD. In the European LeukemiaNet (ELN) 2024 risk‐classification for patients treated with hypomethylating agents plus venetoclax (HMA + VEN)
Fieke W. Hoff, Joshua F. Zeidner, Geeta Torlapati, Deedra Nicolet, Krzysztof Mrózek, Ying Huang, Alexander Li, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Maria R. Baer, Vu H. Duong, William G. Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Rebecca L. Olin, Catherine C. Smith, Gary J. Schiller, Emily K. Curran, Onyee Chan, Christine McMahon, Michael Hochman, Kieran Sahasrabudhe, Charles Foucar, Jesus Gonzalez‐Lugo, Brittany Knick Ragon, Shivani V. Handa, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja G. Marcus, Leonard Rosenberg, Brian J. Druker, Ross L. Levine, Amy Burd, Ashley O. Yocum, Uma M. Borate, Alice S. Mims, Ann‐Katrin Eisfeld, John C. Byrd, Yazan F. Madanat   +44 more
wiley   +1 more source

Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy [PDF]

, 2010
Background: Acute promyelocytic leukemia is a subtype of acute myeloid leukemia characterized by the t(15;17). The incidence and prognostic significance of additional chromosomal abnormalities in acute promyelocytic leukemia is still a controversial ...
Hernández Rivas, Jesús María, Ferro, M.T. (María), Milone, G. (Gustavo), de la Serna, Javier, Gonzalez, Jose D., Luño, E. (Elisa), Rayón, C. (Chelo), Löwenberg, B. (Bob), Montesinos, P. (Pau), Rayon, Chelo, Tormo, M. (Mar), Calasanz, M.J. (Maria), Vellenga, E. (Edo), Brunet, S. (Salut), Rayón Suárez, Consuelo, González, J.D. (José David), Gonzalez, Marcos, Montesinos Fernández, Pau, Milone, Gustavo, Sanz, Miguel A., Amutio, Elena, Calasanz, Maria J., Brunet, Salut, Cervera, J. (José), Amutio, E. (Elena), Luno, Elisa, Hernandez-Rivas, J.M. (J. M.), Cervera Zamora, José Vicente, Rivas, C. (Concha), Sanz, M.A. (Miguel Angel), Cervera, Jose, Hernandez-Rivas, Jesus M., Tormo, Mar, Serna, J. (Javier) de, Rivas, Concha, Ferro, Maria T., Aventín, A. (Anna), Montesinos, Pau, Vellenga, Edo, Sánchez, J. (Javier), Luño Fernández, Elisa, Aventin, Anna, Sanchez, Javier, Lowenberg, Bob, Amutio, E, Elisa Luño, Gonzalez, JD, Gustavo Milone, Hernandez-Rivas, JM, José Cervera, Anna Aventín, Cervera, J, María J. Calasanz, Luno, E, Gonzalez, M, de la Serna, J, Javier Sánchez, Vellenga, E, Aventin, A, José D. González, Sanchez, J, María T. Ferro, Ferro, MT, Chelo Rayón, Rivas, C, Löwenberg, Bob; id_orcid, Marcos González, Miguel A. Sanz, Tormo, M, Javier de la Serna, Elena Amutio, Bob Lowenberg, Rayon, C, Milone, G, Edo Vellenga, Pau Montesinos, Montesinos, P, Calasanz, MJ, Mar Tormo, Jesús M. Hernández-Rivas, Salut Brunet, Brunet, S, Sanz, MA, Concha Rivas   +83 more
core   +3 more sources

USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression

Cell Death Discovery
Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme (DUB) that underlies tumorigenicity, proliferation, cell death and differentiation through deubiquitination of histone and non-histone targets.
Lisa Kowald, Jens Roedig, Rebekka Karlowitz, Kristina Wagner, Sonja Smith, Thomas Juretschke, Petra Beli, Stefan Müller, Sjoerd J. L. van Wijk   +8 more
doaj   +1 more source

ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity

Advanced Science, 2020
Human adenoviruses (HAdV) are associated with clinical symptoms such as gastroenteritis, keratoconjunctivitis, pneumonia, hepatitis, and encephalitis.
Samuel Hofmann, Julia Mai, Sawinee Masser, Peter Groitl, Alexander Herrmann, Thomas Sternsdorf, Ruth Brack‐Werner, Sabrina Schreiner   +7 more
doaj   +1 more source