Results 121 to 130 of about 3,564,161 (186)

Extramedullary relapse in the pleura in acute promyelocytic leukemia

, 2003
PubMedID: 12691162Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloblastic leukemia with specific clinical, morphologic and genetic features and a good response to all trans retinoic acid (ATRA). However, extramedullary (EM) relapse
Yavuz S., Disel U., Paydas S., Sahin B., Zeren H.   +4 more
core   +1 more source

Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia [PDF]

, 2003
Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process.
Elsaesser, Annika
core   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science
Acute promyelocytic leukemia (APL) accounts for 5–15% of acute myeloid leukemia cases. It is typically characterized by the (15;17) chromosomal translocation, producing the pathogenic retinoic acid receptor (RAR) alpha/promyelocytic leukemia (PML) fusion
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
doaj   +1 more source

Acute Promyelocytic Leukemia

, 2010
This image demonstrates a group of promyelocytes in acute promyelocytic ...
Fraser, Marion
core   +1 more source

Overexpression of the protein kinase CK2 increases the survival and resistance to chemotherapy of acute myeloid leukemia cells [PDF]

, 2013
Background: The critical role of protein kinase CK2 in the regulation of cellular apoptosis suggests its may be involvement in tumor cell resistance to both conventional and unconventional therapies.
PAVAN, LAURA
core  

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

, 1993
Acute promyelocytic leukemia is a clonal expansion of hematopoietic precursors blocked at the promyelocytic stage. The differentiation block can be reversed by retinoic acid, which induces blast maturation both in vitro and in vivo.
Myriam Alcalay, F. Grignani, U. Testa, Pier Francesco Ferrucci, Cesare Peschle, G. Talamo, Francesco Grignani, Fausto Grignani, P. F. Ferrucci, Pier Giuseppe Pelicci, M. Fagioli, P. G. Pelicci, M. Alcalay, A. Mencarelli, I. Nicoletti, Giampaolo Talamo, Marta Fagioli, Ugo Testa, Ildo Nicoletti, C. Peschle, Amedea Mencarelli   +20 more
core   +1 more source

Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response

Haematologica, 2006
Rare cases of acute promyelocytic leukemia (APL) are associated with a t(11;17) translocation and a PLZF-RARalpha fusion transcript. Because of molecular specificities of the fusion protein, ATRA efficiency is often reduced in these cases.
B Cassinat, I Guillemot, C Molucon-Chabrot, F Zassadowski, P Fenaux, O Tournilhac, C Chomienne   +6 more
doaj  

Forkhead O Transcription Factor 4 Restricts HBV Covalently Closed Circular DNA Transcription and HBV Replication through Genetic Downregulation of Hepatocyte Nuclear Factor 4 Alpha and Epigenetic Suppression of Covalently Closed Circular DNA via Interacting with Promyelocytic Leukemia Protein. [PDF]

J Virol, 2022
Li Y, He M, Gong R, Wang Z, Lu L, Peng S, Duan Z, Feng Y, Liu Y, Gao B.   +9 more
europepmc   +1 more source

Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia

Genome Medicine
Background Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), characterized by a fusion between the PML and RARA genes and by a block in the myeloid maturation at the promyelocytic stage.
Xiangfu Zhong, Lina Cordeddu, Angelica Gamboa-Cedeno, Sofia Bengtzén, Karl Ekwall, Andreas Lennartsson, Sören Lehmann   +6 more
doaj   +1 more source

Retraction for Bischof et al., "Human Papillomavirus Oncoprotein E7 Targets the Promyelocytic Leukemia Protein and Circumvents Cellular Senescence via the Rb and p53 Tumor Suppressor Pathways". [PDF]

Mol Cell Biol, 2020
Bischof O, Nacerddine K, Dejean A.
europepmc   +1 more source