Results 121 to 130 of about 120,872 (251)

Granulocyte colony-stimulating factor and leukemogenesis

Mediators of Inflammation, 2004
THE granulocyte colony-stimulating factor (G-CSF) plays an important role in normal granulopoiesis. Its functions are mediated by specific receptors on the surface of responsive cells and, upon ligand binding, several cytoplasmic tyrosine kinases are ...
Lorena Lobo de Figueiredo, Rodrigo Siqueira de Abreu e Lima, Eduardo Magalhães Rego   +2 more
doaj   +1 more source

Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Using cyclic multiplex microscopy in an IL‐33‐driven type 2 inflammation model, we validated a spatial workflow mapping rare lung ILCs. High‐dimensional analysis revealed a conserved peri‐lymphatic niche at early time points of inflammation where ILC2s and myeloid cells co‐localize with LYVE1+ vessels, highlighting a structured immunological ...
Sandy Kroh, Anna Pascual‐Reguant, Artür Manukyan, Ralf Uecker, Robert Günther, Lars Philipsen, Ralf Koehler, Peggy Mex, Markus Landthaler, Raluca A. Niesner, Anja E. Hauser   +10 more
wiley   +1 more source

Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry

, 2011
Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce.
S Lehmann, Derolf, A. R., M Höglund, S Deneberg, Antunovic, P, Juliusson, G, Stockelberg, D.,, Möllgård, L, Wennstrom, L., Wennström, L, A Ravn, P Antunovic, Ravn, A., Carlsson, L., Derolf, A Rangert, Wennstrom, L.,, Antunovic, P., Hoglund, M.,, Rangert Derolf, Å, Lehmann, S.,, Tidefelt, U, D Stockelberg, Carlsson, L, Hoglund, M., Antunovic, Petar,, A Wahlin, Carlsson, L.,, Lehmann, S, L Möllgård, G Juliusson, Å Rangert Derolf, Deneberg, S., Tidefelt, Ulf,, Höglund, Martin,, Stockelberg, D, Wahlin, A, Lund University., Juliusson, Gunnar, L Wennström, Mollgard, L., Derolf, A. Rangert, Juliusson, Gunnar,, Ravn, S, Ravn, A, Lehmann, S., Juliusson, G., Wennström, Lovisa,, Stockelberg, D., Wahlin, A., Tidefelt, U., Rangert Derolf, A.,, Lehmann, Sören, Mollgard, L.,, Deneberg, S, Höglund, M, Ravn, A.,, U Tidefelt, Wahlin, A.,, Wahlin, Anders,, Juliusson, G.,, Tidefelt, U.,, L Carlsson, Stockelberg, Dick,, Högberg, M, Deneberg, S.,   +64 more
core   +1 more source

Pharmacological and Phytochemical Insights Into Ficus benghalensis (Indian Banyan): Anti‐Inflammatory, Antioxidant, and Anticancer Potentials

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The aim of this review is to critically evaluate the therapeutic potential of Ficus benghalensis L. by integrating ethnomedicinal knowledge with contemporary scientific evidence. The objectives are to summarize its phytochemical profile, analyze antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and anticancer activities, elucidate underlying
Zainab Ali, Farhang Hameed Awlqadr, Uswa Ali, Iffat Ullah, Muhammad Tayyab Arshad, Abdul Rauf, Humaira Parveen, Sayeed Mukhtar, Uzma Faridi, Md. Sakhawot Hossain   +9 more
wiley   +1 more source

Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity

, 2009
SummaryInterferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diverse effects they elicit are not fully understood.
Scott, Bernadette, Holko, Michelle, Higashiyama, Shigeki, McConnell, Melanie J., Sadler, Anthony J., Williams, Bryan R.G., Pandolfi, Pier Paolo, Licht, Jonathan D., Berkofsky-Fessler, Windy, Xu, Dakang   +9 more
core   +1 more source

Structure and Function of PML Nuclear Bodies: A Brief Overview of Key Cellular Roles

Biomolecules
Promyelocytic leukemia nuclear bodies (PML-NBs) are dynamic membrane-less organelles (MLOs) located in the nucleus that serve as regulatory hubs for multiple cellular processes.
Karolina Dorosz, Lidia Majewska, Jacek Kijowski   +2 more
doaj   +1 more source

Supplementary Figure 1 from SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome

, 2008
Supplementary Figure 1 from SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via ...
Xuefei Cao (1700068), Yuan Chen (9740), H. Helen Lin (5469503), Xu Li (23864), Hsiu-Ming Shih (222985), David K. Ann (665043), Carlos Clavijo (13919755)   +6 more
core   +1 more source

SUMO chain-induced dimerization activates RNF4 [PDF]

, 2014
Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis.
Hay, Ronald T, Rojas-Fernandez, Alejandro, Hattersley, Neil, Plechanovová, Anna, Tatham, Michael H, Jaffray, Ellis   +5 more
core   +1 more source

PML Nuclear bodies: the cancer connection and beyond

Nucleus
Promyelocytic leukemia (PML) nuclear bodies, membrane-less organelles in the nucleus, play a crucial role in cellular homeostasis. These dynamic structures result from the assembly of scaffolding PML proteins and various partners.
Majdouline Abou-Ghali, Valérie Lallemand-Breitenbach   +1 more
doaj   +1 more source

Novel Nuclear Nesprin-2 Variants Tether Active Extracellular Signal-regulated MAPK1 and MAPK2 at Promyelocytic Leukemia Protein Nuclear Bodies and Act to Regulate Smooth Muscle Cell Proliferation*

Journal of Biological Chemistry, 2009
Nuclear and cytoplasmic scaffold proteins have been shown to be essential for temporal and spatial organization, as well as the fidelity, of MAPK signaling pathways. In this study we show that nesprin-2 is a novel extracellular signal-regulated MAPK1 and
D. Warren, T. Tajsic, J. Mellad, R. Searles, Qiuping Zhang, C. Shanahan   +5 more
semanticscholar   +1 more source